Atrophy asymmetry in hippocampal subfields in patients with Alzheimer’s disease and mild cognitive impairment

Volumetric analysis of hippocampal subfields and their asymmetry assessment recently has been useful biomarkers in neuroscience. In this study, hippocampal subfields atrophy and pattern of their asymmetry in the patient with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) were evaluated. MRI images of 20 AD patients, 20 MCI patients, and 20 healthy control (HC) were selected. The volumes of hippocampal subfields were extracted automatically using Freesurfer toolkit. The subfields asymmetry index (AI) and laterality ( Δ R L ) were also evaluated. Analysis of covariance was used to compare the subfields volume between three patient groups (age and gender as covariates). We used ANOVA ( P