Low serum zinc concentration is associated with low serum testosterone but not erectile function
Objective To investigate the relation between serum zinc concentration and several factors, including serum testosterone concentration and the score of questionnaires on sexual function in patients with sexual problems. Methods This study comprised 720 men (age, 46.3 [21–83] years) with some kind of...
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| Veröffentlicht in: | International journal of urology 2023-04, Vol.30 (4), p.395-400 |
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| container_title | International journal of urology |
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| creator | Miyoshi, Miho Tsujimura, Akira Miyoshi, Yuto Uesaka, Yuka Nozaki, Taiji Shirai, Masato Kiuchi, Hiroshi Kobayashi, Kazuhiro Horie, Shigeo |
| description | Objective
To investigate the relation between serum zinc concentration and several factors, including serum testosterone concentration and the score of questionnaires on sexual function in patients with sexual problems.
Methods
This study comprised 720 men (age, 46.3 [21–83] years) with some kind of sexual problem. Age, scores of the Sexual Health Inventory for Men and the Erection Hardness Score, and endocrinologic data including serum concentrations of testosterone, prostate‐specific antigen, and zinc were included in this study. After serum zinc concentration of the men was classified into 5 groups ( |
| doi_str_mv | 10.1111/iju.15138 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2760548507</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2793412381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4128-21fdff51696966ff206283d797da30d65d0980ed155e7136bd3076040af2ee263</originalsourceid><addsrcrecordid>eNp10EtLAzEUBeAgitbqwj8gATe6GJvHPDJLKT4puLHrOE1uMGWaaJKh6K83tepCMHeRzcfhcBA6oeSS5jexy-GSVpSLHTSiZckKRkq2i0akpW0haMMO0GGMS0IoZ1TsowNeV23JWzFCzzO_xhHCsMIf1imsvFPgUuiS9Q7biLsYvbJdAo3XNr3g_tcniMnHBME7wIshYecThgAq2R6wGZzaZByhPdP1EY6__zGa31w_Te-K2ePt_fRqVqiSMlEwarQxFa3bfLUxjNRMcN20je440XWlSSsIaFpV0FBeLzQnTU1K0hkGwGo-Rufb3Nfg34ZcTa5sVND3nQM_RMmyrkpRkSbTsz906YfgcrusWp77cEGzutgqFXyMAYx8DXbVhXdJidzMLvPs8mv2bE-_E4fFCvSv_Nk5g8kWrPM27_8nyfuH-TbyE2Nyi_s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2793412381</pqid></control><display><type>article</type><title>Low serum zinc concentration is associated with low serum testosterone but not erectile function</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Miyoshi, Miho ; Tsujimura, Akira ; Miyoshi, Yuto ; Uesaka, Yuka ; Nozaki, Taiji ; Shirai, Masato ; Kiuchi, Hiroshi ; Kobayashi, Kazuhiro ; Horie, Shigeo</creator><creatorcontrib>Miyoshi, Miho ; Tsujimura, Akira ; Miyoshi, Yuto ; Uesaka, Yuka ; Nozaki, Taiji ; Shirai, Masato ; Kiuchi, Hiroshi ; Kobayashi, Kazuhiro ; Horie, Shigeo</creatorcontrib><description>Objective
To investigate the relation between serum zinc concentration and several factors, including serum testosterone concentration and the score of questionnaires on sexual function in patients with sexual problems.
Methods
This study comprised 720 men (age, 46.3 [21–83] years) with some kind of sexual problem. Age, scores of the Sexual Health Inventory for Men and the Erection Hardness Score, and endocrinologic data including serum concentrations of testosterone, prostate‐specific antigen, and zinc were included in this study. After serum zinc concentration of the men was classified into 5 groups (<70, 70≤ <80, 80≤ <90, 90≤ <100, ≤100 μg/dl), the relation of each parameter with serum zinc concentration was assessed for a trend analysis. Finally, the relation between serum concentrations of zinc and testosterone as well sexual function evaluated by the scores of the questionnaires was investigated.
Results
Only serum testosterone concentration (ptrend = 0.028) and serum cortisol concentration (ptrend = 0.003) showed a statistically significant relation to serum zinc concentration by trend analysis. Interestingly, trend analysis between serum concentrations of testosterone and zinc still showed a significant association after adjustment for serum cortisol concentration (ptrend = 0.032). However, no significant association was found in the relation between serum zinc concentration and the scores of the questionnaires after adjustment for serum concentrations of testosterone and cortisol.
Conclusion
We clearly showed that after adjustment for serum cortisol concentration by trend analysis, serum testosterone concentration decreased as serum zinc concentration decreased, although sexual symptoms were not associated with this decrease.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.15138</identifier><identifier>PMID: 36594398</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Cortisol ; Erectile Dysfunction ; Hormones ; Humans ; Hydrocortisone ; Male ; Middle Aged ; Penile Erection ; Prostate-Specific Antigen ; Questionnaires ; serum cortisol concentration ; serum testosterone concentration ; serum zinc concentration ; sexual dysfunction ; Statistical analysis ; Testosterone ; Zinc</subject><ispartof>International journal of urology, 2023-04, Vol.30 (4), p.395-400</ispartof><rights>2022 The Japanese Urological Association.</rights><rights>2023 The Japanese Urological Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4128-21fdff51696966ff206283d797da30d65d0980ed155e7136bd3076040af2ee263</citedby><cites>FETCH-LOGICAL-c4128-21fdff51696966ff206283d797da30d65d0980ed155e7136bd3076040af2ee263</cites><orcidid>0000-0003-3886-2506 ; 0000-0002-3821-5184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.15138$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.15138$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36594398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyoshi, Miho</creatorcontrib><creatorcontrib>Tsujimura, Akira</creatorcontrib><creatorcontrib>Miyoshi, Yuto</creatorcontrib><creatorcontrib>Uesaka, Yuka</creatorcontrib><creatorcontrib>Nozaki, Taiji</creatorcontrib><creatorcontrib>Shirai, Masato</creatorcontrib><creatorcontrib>Kiuchi, Hiroshi</creatorcontrib><creatorcontrib>Kobayashi, Kazuhiro</creatorcontrib><creatorcontrib>Horie, Shigeo</creatorcontrib><title>Low serum zinc concentration is associated with low serum testosterone but not erectile function</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objective
To investigate the relation between serum zinc concentration and several factors, including serum testosterone concentration and the score of questionnaires on sexual function in patients with sexual problems.
Methods
This study comprised 720 men (age, 46.3 [21–83] years) with some kind of sexual problem. Age, scores of the Sexual Health Inventory for Men and the Erection Hardness Score, and endocrinologic data including serum concentrations of testosterone, prostate‐specific antigen, and zinc were included in this study. After serum zinc concentration of the men was classified into 5 groups (<70, 70≤ <80, 80≤ <90, 90≤ <100, ≤100 μg/dl), the relation of each parameter with serum zinc concentration was assessed for a trend analysis. Finally, the relation between serum concentrations of zinc and testosterone as well sexual function evaluated by the scores of the questionnaires was investigated.
Results
Only serum testosterone concentration (ptrend = 0.028) and serum cortisol concentration (ptrend = 0.003) showed a statistically significant relation to serum zinc concentration by trend analysis. Interestingly, trend analysis between serum concentrations of testosterone and zinc still showed a significant association after adjustment for serum cortisol concentration (ptrend = 0.032). However, no significant association was found in the relation between serum zinc concentration and the scores of the questionnaires after adjustment for serum concentrations of testosterone and cortisol.
Conclusion
We clearly showed that after adjustment for serum cortisol concentration by trend analysis, serum testosterone concentration decreased as serum zinc concentration decreased, although sexual symptoms were not associated with this decrease.</description><subject>Cortisol</subject><subject>Erectile Dysfunction</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hydrocortisone</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Penile Erection</subject><subject>Prostate-Specific Antigen</subject><subject>Questionnaires</subject><subject>serum cortisol concentration</subject><subject>serum testosterone concentration</subject><subject>serum zinc concentration</subject><subject>sexual dysfunction</subject><subject>Statistical analysis</subject><subject>Testosterone</subject><subject>Zinc</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EtLAzEUBeAgitbqwj8gATe6GJvHPDJLKT4puLHrOE1uMGWaaJKh6K83tepCMHeRzcfhcBA6oeSS5jexy-GSVpSLHTSiZckKRkq2i0akpW0haMMO0GGMS0IoZ1TsowNeV23JWzFCzzO_xhHCsMIf1imsvFPgUuiS9Q7biLsYvbJdAo3XNr3g_tcniMnHBME7wIshYecThgAq2R6wGZzaZByhPdP1EY6__zGa31w_Te-K2ePt_fRqVqiSMlEwarQxFa3bfLUxjNRMcN20je440XWlSSsIaFpV0FBeLzQnTU1K0hkGwGo-Rufb3Nfg34ZcTa5sVND3nQM_RMmyrkpRkSbTsz906YfgcrusWp77cEGzutgqFXyMAYx8DXbVhXdJidzMLvPs8mv2bE-_E4fFCvSv_Nk5g8kWrPM27_8nyfuH-TbyE2Nyi_s</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Miyoshi, Miho</creator><creator>Tsujimura, Akira</creator><creator>Miyoshi, Yuto</creator><creator>Uesaka, Yuka</creator><creator>Nozaki, Taiji</creator><creator>Shirai, Masato</creator><creator>Kiuchi, Hiroshi</creator><creator>Kobayashi, Kazuhiro</creator><creator>Horie, Shigeo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3886-2506</orcidid><orcidid>https://orcid.org/0000-0002-3821-5184</orcidid></search><sort><creationdate>202304</creationdate><title>Low serum zinc concentration is associated with low serum testosterone but not erectile function</title><author>Miyoshi, Miho ; Tsujimura, Akira ; Miyoshi, Yuto ; Uesaka, Yuka ; Nozaki, Taiji ; Shirai, Masato ; Kiuchi, Hiroshi ; Kobayashi, Kazuhiro ; Horie, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4128-21fdff51696966ff206283d797da30d65d0980ed155e7136bd3076040af2ee263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cortisol</topic><topic>Erectile Dysfunction</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hydrocortisone</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Penile Erection</topic><topic>Prostate-Specific Antigen</topic><topic>Questionnaires</topic><topic>serum cortisol concentration</topic><topic>serum testosterone concentration</topic><topic>serum zinc concentration</topic><topic>sexual dysfunction</topic><topic>Statistical analysis</topic><topic>Testosterone</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyoshi, Miho</creatorcontrib><creatorcontrib>Tsujimura, Akira</creatorcontrib><creatorcontrib>Miyoshi, Yuto</creatorcontrib><creatorcontrib>Uesaka, Yuka</creatorcontrib><creatorcontrib>Nozaki, Taiji</creatorcontrib><creatorcontrib>Shirai, Masato</creatorcontrib><creatorcontrib>Kiuchi, Hiroshi</creatorcontrib><creatorcontrib>Kobayashi, Kazuhiro</creatorcontrib><creatorcontrib>Horie, Shigeo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyoshi, Miho</au><au>Tsujimura, Akira</au><au>Miyoshi, Yuto</au><au>Uesaka, Yuka</au><au>Nozaki, Taiji</au><au>Shirai, Masato</au><au>Kiuchi, Hiroshi</au><au>Kobayashi, Kazuhiro</au><au>Horie, Shigeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum zinc concentration is associated with low serum testosterone but not erectile function</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2023-04</date><risdate>2023</risdate><volume>30</volume><issue>4</issue><spage>395</spage><epage>400</epage><pages>395-400</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objective
To investigate the relation between serum zinc concentration and several factors, including serum testosterone concentration and the score of questionnaires on sexual function in patients with sexual problems.
Methods
This study comprised 720 men (age, 46.3 [21–83] years) with some kind of sexual problem. Age, scores of the Sexual Health Inventory for Men and the Erection Hardness Score, and endocrinologic data including serum concentrations of testosterone, prostate‐specific antigen, and zinc were included in this study. After serum zinc concentration of the men was classified into 5 groups (<70, 70≤ <80, 80≤ <90, 90≤ <100, ≤100 μg/dl), the relation of each parameter with serum zinc concentration was assessed for a trend analysis. Finally, the relation between serum concentrations of zinc and testosterone as well sexual function evaluated by the scores of the questionnaires was investigated.
Results
Only serum testosterone concentration (ptrend = 0.028) and serum cortisol concentration (ptrend = 0.003) showed a statistically significant relation to serum zinc concentration by trend analysis. Interestingly, trend analysis between serum concentrations of testosterone and zinc still showed a significant association after adjustment for serum cortisol concentration (ptrend = 0.032). However, no significant association was found in the relation between serum zinc concentration and the scores of the questionnaires after adjustment for serum concentrations of testosterone and cortisol.
Conclusion
We clearly showed that after adjustment for serum cortisol concentration by trend analysis, serum testosterone concentration decreased as serum zinc concentration decreased, although sexual symptoms were not associated with this decrease.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36594398</pmid><doi>10.1111/iju.15138</doi><tpages>400</tpages><orcidid>https://orcid.org/0000-0003-3886-2506</orcidid><orcidid>https://orcid.org/0000-0002-3821-5184</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cortisol Erectile Dysfunction Hormones Humans Hydrocortisone Male Middle Aged Penile Erection Prostate-Specific Antigen Questionnaires serum cortisol concentration serum testosterone concentration serum zinc concentration sexual dysfunction Statistical analysis Testosterone Zinc |
| title | Low serum zinc concentration is associated with low serum testosterone but not erectile function |
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