Untargeted metabolomics reveals the combination effects and mechanisms of Huangqi-fuzi herb-pair against doxorubicin-induced cardiotoxicity

Qifu decoction (QFD) is a famous traditional Chinese medicine (TCM) composed of Astragali Radix (HuangQi) and Aconiti Lateralis Radix Praeparaia (Fuzi), which can alleviate doxorubicin (DOX)-induced cardiotoxicity (DIC). However, its protective mechanism remains obscured. The present study aimed to...

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Veröffentlicht in:	Journal of ethnopharmacology 2023-04, Vol.305, p.116109-116109, Article 116109
Hauptverfasser:	Xue, Zhen, Zhuo, Lingxin, Zhang, Bowen, Zhu, Lingmeng, Xiang, Xinran, Zhang, Chunxia, Liu, Wenyuan, Tan, Guangguo, Liao, Wenting
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiotoxicity - drug therapy Cardiotoxicity - etiology Diterpenes Doxorubicin - toxicity Doxorubicin-induced cardiotoxicity Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Mass Spectrometry Metabolomics Mice Qifu decoction Synergistic effect
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