Estimation of a cut-off value for immature platelet fraction (IPF) in predicting platelet recovery in dengue patients with thrombocytopenia
Thrombocytopenia is a common complication in dengue that sometimes necessitates platelet transfusion. Immature platelet fraction (IPF) measures immature platelets that indirectly reflect thrombopoiesis and is helpful in predicting platelet recovery. This study aimed to evaluate the role of IPF% and...
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| Veröffentlicht in: | Malaysian journal of pathology 2022-12, Vol.44 (3), p.499-508 |
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| container_title | Malaysian journal of pathology |
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| creator | Ahmad, J Md Noor, S Mustapha, S Z Idris, F |
| description | Thrombocytopenia is a common complication in dengue that sometimes necessitates platelet transfusion. Immature platelet fraction (IPF) measures immature platelets that indirectly reflect thrombopoiesis and is helpful in predicting platelet recovery.
This study aimed to evaluate the role of IPF% and identify its cut-off value in predicting platelet recovery in dengue patients with thrombocytopenia.
Serial platelet count and IPF results were obtained from fifty-four confirmed dengue patients with platelet count |
| format | Article |
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This study aimed to evaluate the role of IPF% and identify its cut-off value in predicting platelet recovery in dengue patients with thrombocytopenia.
Serial platelet count and IPF results were obtained from fifty-four confirmed dengue patients with platelet count <50x109 /L. Median peak IPF% and number of patients with platelet recovery were determined. Receiver operating characteristic (ROC) curve is generated to identify the IPF% cut-off value to predict platelet recovery.
Median peak IPF% among dengue patients was 12.15% with 83.3% of them achieving platelet recovery after reaching the peak IPF%. There was a significant difference between median IPF% on day one of admission with peak IPF% among dengue patients. ROC curve analysis showed IFP% of 10.55% can be used to predict platelet recovery with a sensitivity of 69% and a specificity of 67%.
IPF% is a reliable and useful parameter in predicting platelet recovery in dengue patients. This would assist the clinician in managing dengue patients especially those with severe thrombocytopenia without giving unnecessary platelet transfusion.</description><identifier>ISSN: 0126-8635</identifier><identifier>PMID: 36591717</identifier><language>eng</language><publisher>Malaysia: College of Pathologists, Academy of Medicine of Malaysia</publisher><subject>Blood & organ donations ; Blood Platelets ; Bone marrow ; Dengue - complications ; Dengue fever ; Humans ; Laboratories ; Patients ; Platelet Count - methods ; Platelet Transfusion - adverse effects ; Thrombocytopenia ; Thrombocytopenia - etiology</subject><ispartof>Malaysian journal of pathology, 2022-12, Vol.44 (3), p.499-508</ispartof><rights>Copyright College of Pathologists, Academy of Medicine of Malaysia Dec 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36591717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmad, J</creatorcontrib><creatorcontrib>Md Noor, S</creatorcontrib><creatorcontrib>Mustapha, S Z</creatorcontrib><creatorcontrib>Idris, F</creatorcontrib><title>Estimation of a cut-off value for immature platelet fraction (IPF) in predicting platelet recovery in dengue patients with thrombocytopenia</title><title>Malaysian journal of pathology</title><addtitle>Malays J Pathol</addtitle><description>Thrombocytopenia is a common complication in dengue that sometimes necessitates platelet transfusion. Immature platelet fraction (IPF) measures immature platelets that indirectly reflect thrombopoiesis and is helpful in predicting platelet recovery.
This study aimed to evaluate the role of IPF% and identify its cut-off value in predicting platelet recovery in dengue patients with thrombocytopenia.
Serial platelet count and IPF results were obtained from fifty-four confirmed dengue patients with platelet count <50x109 /L. Median peak IPF% and number of patients with platelet recovery were determined. Receiver operating characteristic (ROC) curve is generated to identify the IPF% cut-off value to predict platelet recovery.
Median peak IPF% among dengue patients was 12.15% with 83.3% of them achieving platelet recovery after reaching the peak IPF%. There was a significant difference between median IPF% on day one of admission with peak IPF% among dengue patients. ROC curve analysis showed IFP% of 10.55% can be used to predict platelet recovery with a sensitivity of 69% and a specificity of 67%.
IPF% is a reliable and useful parameter in predicting platelet recovery in dengue patients. This would assist the clinician in managing dengue patients especially those with severe thrombocytopenia without giving unnecessary platelet transfusion.</description><subject>Blood & organ donations</subject><subject>Blood Platelets</subject><subject>Bone marrow</subject><subject>Dengue - complications</subject><subject>Dengue fever</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Patients</subject><subject>Platelet Count - methods</subject><subject>Platelet Transfusion - adverse effects</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - etiology</subject><issn>0126-8635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkFFLwzAUhfuguDn9CxLwZT4UmqRJ20cZmw4EfdDnkqQ3W0ab1DSd7Df4p810Ivh04Z7vnnM5Z8k0w4SnJadsklwOwy7LeF5V5UUyoZxVuMDFNPlcDsF0IhhnkdNIIDWG1GmN9qIdAWnnkemiPnpAfSsCtBCQ9kJ9X8zXL6s7ZCzqPTQm7uzmj_Kg3B784ag3YDfRro9BYMOAPkzYorD1rpNOHYLrwRpxlZxr0Q5wfZqz5G21fF08pk_PD-vF_VPaE1qFlDCJaaYyVZZS5UxILcuSYiJzQRguAAA3pcyqPNeCC6g0Z6qgjCrAnCui6SyZ__j23r2PMIS6M4OCthUW3DjUpOBZbAfnJKK3_9CdG72N3x0pEjN4xSJ1c6JG2UFT9z5W6g_1b830C50gekg</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Ahmad, J</creator><creator>Md Noor, S</creator><creator>Mustapha, S Z</creator><creator>Idris, F</creator><general>College of Pathologists, Academy of Medicine of Malaysia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20221201</creationdate><title>Estimation of a cut-off value for immature platelet fraction (IPF) in predicting platelet recovery in dengue patients with thrombocytopenia</title><author>Ahmad, J ; Md Noor, S ; Mustapha, S Z ; Idris, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-25b130c0c88bc45abfb88312b4a2517eee1d8b0944fa6ae9f65c7353ce166c2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Blood & organ donations</topic><topic>Blood Platelets</topic><topic>Bone marrow</topic><topic>Dengue - complications</topic><topic>Dengue fever</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Patients</topic><topic>Platelet Count - methods</topic><topic>Platelet Transfusion - adverse effects</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmad, J</creatorcontrib><creatorcontrib>Md Noor, S</creatorcontrib><creatorcontrib>Mustapha, S Z</creatorcontrib><creatorcontrib>Idris, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Malaysian journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmad, J</au><au>Md Noor, S</au><au>Mustapha, S Z</au><au>Idris, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of a cut-off value for immature platelet fraction (IPF) in predicting platelet recovery in dengue patients with thrombocytopenia</atitle><jtitle>Malaysian journal of pathology</jtitle><addtitle>Malays J Pathol</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>44</volume><issue>3</issue><spage>499</spage><epage>508</epage><pages>499-508</pages><issn>0126-8635</issn><abstract>Thrombocytopenia is a common complication in dengue that sometimes necessitates platelet transfusion. Immature platelet fraction (IPF) measures immature platelets that indirectly reflect thrombopoiesis and is helpful in predicting platelet recovery.
This study aimed to evaluate the role of IPF% and identify its cut-off value in predicting platelet recovery in dengue patients with thrombocytopenia.
Serial platelet count and IPF results were obtained from fifty-four confirmed dengue patients with platelet count <50x109 /L. Median peak IPF% and number of patients with platelet recovery were determined. Receiver operating characteristic (ROC) curve is generated to identify the IPF% cut-off value to predict platelet recovery.
Median peak IPF% among dengue patients was 12.15% with 83.3% of them achieving platelet recovery after reaching the peak IPF%. There was a significant difference between median IPF% on day one of admission with peak IPF% among dengue patients. ROC curve analysis showed IFP% of 10.55% can be used to predict platelet recovery with a sensitivity of 69% and a specificity of 67%.
IPF% is a reliable and useful parameter in predicting platelet recovery in dengue patients. This would assist the clinician in managing dengue patients especially those with severe thrombocytopenia without giving unnecessary platelet transfusion.</abstract><cop>Malaysia</cop><pub>College of Pathologists, Academy of Medicine of Malaysia</pub><pmid>36591717</pmid><tpages>10</tpages></addata></record> |
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| ispartof | Malaysian journal of pathology, 2022-12, Vol.44 (3), p.499-508 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Blood & organ donations Blood Platelets Bone marrow Dengue - complications Dengue fever Humans Laboratories Patients Platelet Count - methods Platelet Transfusion - adverse effects Thrombocytopenia Thrombocytopenia - etiology |
| title | Estimation of a cut-off value for immature platelet fraction (IPF) in predicting platelet recovery in dengue patients with thrombocytopenia |
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