Morphine use induces gastric microbial dysbiosis driving gastric inflammation through TLR2 signalling which is attenuated by proton pump inhibition

Background and Purpose Opioids are the standard drug for pain management; however, their effects on gastric dysfunction are relatively understudied. Opioid users have a higher incidence of gastric pathology leading to increased hospitalization. Herein, we investigated the consequences of morphine us...

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Veröffentlicht in:British journal of pharmacology 2023-06, Vol.180 (12), p.1582-1596
Hauptverfasser: Ghosh, Nillu, Kesh, Kousik, Singh, Praveen Kumar, Sharma, Umakant, Chupikova, Irina, Ramakrishnan, Sundaram, Roy, Sabita
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Sprache:eng
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