Bad is essential for Bcl-xL-enhanced Bax shuttling between mitochondria and cytosol

Although Bcl-xL has been shown to retrotranslocate Bax from mitochondria to cytosol, other studies have found that Bcl-xL also stabilizes the mitochondrial localization of Bax. It is still unclear what causes the difference in Bcl-xL-regulated Bax localization. Bad, a BH3-only protein with a high af...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2023-02, Vol.155, p.106359-106359, Article 106359
Hauptverfasser:	Mai, Zihao, Sun, Han, Yang, Fangfang, Du, Mengyan, Cheng, Xuecheng, Chen, Hongce, Sun, Beini, Wen, Junlin, Wang, Xiaoping, Chen, Tongsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Apoptosis Bad Bax bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism Bcl-xL Cytosol - metabolism Mitochondria - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Retrotranslocation Translocation
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