Novel small molecule MRGPRX2 antagonists inhibit a murine model of allergic reaction

Activation of Mas-related G protein–coupled receptor X2 (MRGPRX2) is a crucial non-IgE pathway for mast cell activation associated with allergic reactions and inflammation. Only a few peptides and small compounds targeting MRGPRX2 have been reported, with limited information on their pharmacologic a...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2023-04, Vol.151 (4), p.1110-1122
Hauptverfasser:	Kumar, Mukesh, Duraisamy, Karthi, Annapureddy, Rajasekar Reddy, Chan, Chi Bun, Chow, Billy K.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylaxis - pathology Animals Cell Degranulation Chemokines - metabolism Disease Models, Animal Humans Inflammation Inflammation - pathology mast cell activation Mast Cells - pathology Mice Nerve Tissue Proteins - metabolism non-IgE–mediated allergies Receptors, G-Protein-Coupled - metabolism Receptors, Neuropeptide - metabolism skin structure aided drug designing
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