Metabolic Engineering: Methodologies and Applications
Metabolic engineering aims to improve the production of economically valuable molecules through the genetic manipulation of microbial metabolism. While the discipline is a little over 30 years old, advancements in metabolic engineering have given way to industrial-level molecule production benefitti...
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| Veröffentlicht in: | Chemical reviews 2023-05, Vol.123 (9), p.5521-5570 |
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| container_end_page | 5570 |
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| container_issue | 9 |
| container_start_page | 5521 |
| container_title | Chemical reviews |
| container_volume | 123 |
| creator | Volk, Michael J. Tran, Vinh G. Tan, Shih-I Mishra, Shekhar Fatma, Zia Boob, Aashutosh Li, Hongxiang Xue, Pu Martin, Teresa A. Zhao, Huimin |
| description | Metabolic engineering aims to improve the production of economically valuable molecules through the genetic manipulation of microbial metabolism. While the discipline is a little over 30 years old, advancements in metabolic engineering have given way to industrial-level molecule production benefitting multiple industries such as chemical, agriculture, food, pharmaceutical, and energy industries. This review describes the design, build, test, and learn steps necessary for leading a successful metabolic engineering campaign. Moreover, we highlight major applications of metabolic engineering, including synthesizing chemicals and fuels, broadening substrate utilization, and improving host robustness with a focus on specific case studies. Finally, we conclude with a discussion on perspectives and future challenges related to metabolic engineering. |
| doi_str_mv | 10.1021/acs.chemrev.2c00403 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0009-2665 |
| ispartof | Chemical reviews, 2023-05, Vol.123 (9), p.5521-5570 |
| issn | 0009-2665 1520-6890 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Engineering Industry Metabolic Engineering Metabolism Microorganisms Substrates |
| title | Metabolic Engineering: Methodologies and Applications |
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