Beneficial effects of Helicobacter pylori eradication in systemic sclerosis patients
Summary Objective Previous studies have shown that Helicobacter pylori (HP) infection is associated with increased activity and severity of systemic sclerosis (SSc), hence we aimed to evaluate the effect of HP eradication on various symptoms and inflammatory indices. Methods The SSc patients without...
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| Veröffentlicht in: | Wiener Klinische Wochenschrift 2023-08, Vol.135 (15-16), p.414-419 |
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| container_issue | 15-16 |
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| container_title | Wiener Klinische Wochenschrift |
| container_volume | 135 |
| creator | Radić, Mislav Kaliterna, Dušanka Martinović Bonacin, Damir Vergles, Jadranka Morović Radić, Josipa Fabijanić, Damir Kovačić, Vedran |
| description | Summary
Objective
Previous studies have shown that
Helicobacter pylori
(HP) infection is associated with increased activity and severity of systemic sclerosis (SSc), hence we aimed to evaluate the effect of HP eradication on various symptoms and inflammatory indices.
Methods
The SSc patients without dyspeptic symptoms were prospectively enrolled in this 18-month cross-sectional study. Patients were divided into two groups based on determination of HP infection. The infected group was treated in accordance with the current HP eradication protocol. Assessment of disease activity, severity and organ involvement was performed every 6 months.
Results
A total of 42 consecutive SSc patients without dyspepsia and variable disease activity and severity were recruited. Levels of modified Rodnan skin score, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) significantly decreased following HP eradication (
p
|
| doi_str_mv | 10.1007/s00508-022-02142-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2759959456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2759959456</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-bf99e8c343c2a8eeeab8124b93dbbb8554e7f078b5b94c85c391633756eef5c73</originalsourceid><addsrcrecordid>eNp9kLtOAzEQRS0EIiHwAxTIJc2Cn2u7hAgIEhJNqC3bGSNHm91gb4r8PYYAJcVoivvQzEHokpIbSoi6LYRIohvCWB0qWKOP0JS2lDeqVfQYTQkRvJGcyQk6K2VNCJdC0VM04a3UXAk9Rct76CGmkFyHIUYIY8FDxAvoUhi8CyNkvN13Q04Yslul4MY09Dj1uOzLCJsUcAkd5KGkgrdVhH4s5-gkuq7Axc-eobfHh-V80by8Pj3P716awIweGx-NAR244IE5DQDOa8qEN3zlvddSClCRKO2lNyJoGbihLedKtgBRBsVn6PrQu83Dxw7KaDepBOg618OwK5YpaYw0QrbVyg7WUE8tGaLd5rRxeW8psV807YGmrTTtN02ra-jqp3_nN7D6i_ziqwZ-MJQq9e-Q7XrY5b7-_F_tJ7JwgSw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2759959456</pqid></control><display><type>article</type><title>Beneficial effects of Helicobacter pylori eradication in systemic sclerosis patients</title><source>SpringerNature Journals</source><creator>Radić, Mislav ; Kaliterna, Dušanka Martinović ; Bonacin, Damir ; Vergles, Jadranka Morović ; Radić, Josipa ; Fabijanić, Damir ; Kovačić, Vedran</creator><creatorcontrib>Radić, Mislav ; Kaliterna, Dušanka Martinović ; Bonacin, Damir ; Vergles, Jadranka Morović ; Radić, Josipa ; Fabijanić, Damir ; Kovačić, Vedran</creatorcontrib><description>Summary
Objective
Previous studies have shown that
Helicobacter pylori
(HP) infection is associated with increased activity and severity of systemic sclerosis (SSc), hence we aimed to evaluate the effect of HP eradication on various symptoms and inflammatory indices.
Methods
The SSc patients without dyspeptic symptoms were prospectively enrolled in this 18-month cross-sectional study. Patients were divided into two groups based on determination of HP infection. The infected group was treated in accordance with the current HP eradication protocol. Assessment of disease activity, severity and organ involvement was performed every 6 months.
Results
A total of 42 consecutive SSc patients without dyspepsia and variable disease activity and severity were recruited. Levels of modified Rodnan skin score, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) significantly decreased following HP eradication (
p
< 0.001,
p
< 0.001 and
p
= 0.001, respectively), and in the HP-negative patient group ESR and CRP values increased (
p
= 0.03,
p
= 0.002). Eradication of HP in the group of infected patients induced progressive and significant improvement of disease activity and severity over time compared to baseline (
p
< 0.01,
p
< 0.001, respectively), whereas in the HP-negative patient group these scores remained unchanged. In our study, HP eradication was associated with an improvement of clinical symptoms and disease activity.
Conclusion
These findings suggest that HP detection and subsequent eradication could be beneficial in the management of SSc patients. Although, HP eradication seems to be advantageous in infected SSc patients, larger controlled studies are needed for a potential recommendation.</description><identifier>ISSN: 0043-5325</identifier><identifier>EISSN: 1613-7671</identifier><identifier>DOI: 10.1007/s00508-022-02142-8</identifier><identifier>PMID: 36583748</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Endocrinology ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Original Article ; Pneumology/Respiratory System</subject><ispartof>Wiener Klinische Wochenschrift, 2023-08, Vol.135 (15-16), p.414-419</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-bf99e8c343c2a8eeeab8124b93dbbb8554e7f078b5b94c85c391633756eef5c73</cites><orcidid>0000-0003-0350-6800</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00508-022-02142-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00508-022-02142-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36583748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radić, Mislav</creatorcontrib><creatorcontrib>Kaliterna, Dušanka Martinović</creatorcontrib><creatorcontrib>Bonacin, Damir</creatorcontrib><creatorcontrib>Vergles, Jadranka Morović</creatorcontrib><creatorcontrib>Radić, Josipa</creatorcontrib><creatorcontrib>Fabijanić, Damir</creatorcontrib><creatorcontrib>Kovačić, Vedran</creatorcontrib><title>Beneficial effects of Helicobacter pylori eradication in systemic sclerosis patients</title><title>Wiener Klinische Wochenschrift</title><addtitle>Wien Klin Wochenschr</addtitle><addtitle>Wien Klin Wochenschr</addtitle><description>Summary
Objective
Previous studies have shown that
Helicobacter pylori
(HP) infection is associated with increased activity and severity of systemic sclerosis (SSc), hence we aimed to evaluate the effect of HP eradication on various symptoms and inflammatory indices.
Methods
The SSc patients without dyspeptic symptoms were prospectively enrolled in this 18-month cross-sectional study. Patients were divided into two groups based on determination of HP infection. The infected group was treated in accordance with the current HP eradication protocol. Assessment of disease activity, severity and organ involvement was performed every 6 months.
Results
A total of 42 consecutive SSc patients without dyspepsia and variable disease activity and severity were recruited. Levels of modified Rodnan skin score, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) significantly decreased following HP eradication (
p
< 0.001,
p
< 0.001 and
p
= 0.001, respectively), and in the HP-negative patient group ESR and CRP values increased (
p
= 0.03,
p
= 0.002). Eradication of HP in the group of infected patients induced progressive and significant improvement of disease activity and severity over time compared to baseline (
p
< 0.01,
p
< 0.001, respectively), whereas in the HP-negative patient group these scores remained unchanged. In our study, HP eradication was associated with an improvement of clinical symptoms and disease activity.
Conclusion
These findings suggest that HP detection and subsequent eradication could be beneficial in the management of SSc patients. Although, HP eradication seems to be advantageous in infected SSc patients, larger controlled studies are needed for a potential recommendation.</description><subject>Endocrinology</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pneumology/Respiratory System</subject><issn>0043-5325</issn><issn>1613-7671</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOAzEQRS0EIiHwAxTIJc2Cn2u7hAgIEhJNqC3bGSNHm91gb4r8PYYAJcVoivvQzEHokpIbSoi6LYRIohvCWB0qWKOP0JS2lDeqVfQYTQkRvJGcyQk6K2VNCJdC0VM04a3UXAk9Rct76CGmkFyHIUYIY8FDxAvoUhi8CyNkvN13Q04Yslul4MY09Dj1uOzLCJsUcAkd5KGkgrdVhH4s5-gkuq7Axc-eobfHh-V80by8Pj3P716awIweGx-NAR244IE5DQDOa8qEN3zlvddSClCRKO2lNyJoGbihLedKtgBRBsVn6PrQu83Dxw7KaDepBOg618OwK5YpaYw0QrbVyg7WUE8tGaLd5rRxeW8psV807YGmrTTtN02ra-jqp3_nN7D6i_ziqwZ-MJQq9e-Q7XrY5b7-_F_tJ7JwgSw</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Radić, Mislav</creator><creator>Kaliterna, Dušanka Martinović</creator><creator>Bonacin, Damir</creator><creator>Vergles, Jadranka Morović</creator><creator>Radić, Josipa</creator><creator>Fabijanić, Damir</creator><creator>Kovačić, Vedran</creator><general>Springer Vienna</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0350-6800</orcidid></search><sort><creationdate>20230801</creationdate><title>Beneficial effects of Helicobacter pylori eradication in systemic sclerosis patients</title><author>Radić, Mislav ; Kaliterna, Dušanka Martinović ; Bonacin, Damir ; Vergles, Jadranka Morović ; Radić, Josipa ; Fabijanić, Damir ; Kovačić, Vedran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-bf99e8c343c2a8eeeab8124b93dbbb8554e7f078b5b94c85c391633756eef5c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Endocrinology</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pneumology/Respiratory System</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radić, Mislav</creatorcontrib><creatorcontrib>Kaliterna, Dušanka Martinović</creatorcontrib><creatorcontrib>Bonacin, Damir</creatorcontrib><creatorcontrib>Vergles, Jadranka Morović</creatorcontrib><creatorcontrib>Radić, Josipa</creatorcontrib><creatorcontrib>Fabijanić, Damir</creatorcontrib><creatorcontrib>Kovačić, Vedran</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Wiener Klinische Wochenschrift</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radić, Mislav</au><au>Kaliterna, Dušanka Martinović</au><au>Bonacin, Damir</au><au>Vergles, Jadranka Morović</au><au>Radić, Josipa</au><au>Fabijanić, Damir</au><au>Kovačić, Vedran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial effects of Helicobacter pylori eradication in systemic sclerosis patients</atitle><jtitle>Wiener Klinische Wochenschrift</jtitle><stitle>Wien Klin Wochenschr</stitle><addtitle>Wien Klin Wochenschr</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>135</volume><issue>15-16</issue><spage>414</spage><epage>419</epage><pages>414-419</pages><issn>0043-5325</issn><eissn>1613-7671</eissn><abstract>Summary
Objective
Previous studies have shown that
Helicobacter pylori
(HP) infection is associated with increased activity and severity of systemic sclerosis (SSc), hence we aimed to evaluate the effect of HP eradication on various symptoms and inflammatory indices.
Methods
The SSc patients without dyspeptic symptoms were prospectively enrolled in this 18-month cross-sectional study. Patients were divided into two groups based on determination of HP infection. The infected group was treated in accordance with the current HP eradication protocol. Assessment of disease activity, severity and organ involvement was performed every 6 months.
Results
A total of 42 consecutive SSc patients without dyspepsia and variable disease activity and severity were recruited. Levels of modified Rodnan skin score, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) significantly decreased following HP eradication (
p
< 0.001,
p
< 0.001 and
p
= 0.001, respectively), and in the HP-negative patient group ESR and CRP values increased (
p
= 0.03,
p
= 0.002). Eradication of HP in the group of infected patients induced progressive and significant improvement of disease activity and severity over time compared to baseline (
p
< 0.01,
p
< 0.001, respectively), whereas in the HP-negative patient group these scores remained unchanged. In our study, HP eradication was associated with an improvement of clinical symptoms and disease activity.
Conclusion
These findings suggest that HP detection and subsequent eradication could be beneficial in the management of SSc patients. Although, HP eradication seems to be advantageous in infected SSc patients, larger controlled studies are needed for a potential recommendation.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>36583748</pmid><doi>10.1007/s00508-022-02142-8</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0350-6800</orcidid></addata></record> |
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| subjects | Endocrinology Gastroenterology Internal Medicine Medicine Medicine & Public Health Original Article Pneumology/Respiratory System |
| title | Beneficial effects of Helicobacter pylori eradication in systemic sclerosis patients |
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