Peroxisome proliferator-activated receptors-alpha and gamma synergism modulate the gut-adipose tissue axis and mitigate obesity

To evaluate the effects of single PPARα or PPARγ activation, and their synergism (combined PPARα/γ activation) upon the gut-adipose tissue axis, focusing on the endotoxemia and upstream interscapular brown adipose tissue (iBAT) function in high-saturated fat-fed mice. Methods: Male C57BL/6 mice rece...

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Veröffentlicht in:Molecular and cellular endocrinology 2023-02, Vol.562, p.111839-111839, Article 111839
Hauptverfasser: Miranda, Carolline Santos, Silva-Veiga, Flávia Maria, Fernandes-da-Silva, Aline, Guimarães Pereira, Vitória Regina, Martins, Bruna Cadete, Daleprane, Julio Beltrame, Martins, Fabiane Ferreira, Souza-Mello, Vanessa
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