Long-term vonoprazan administration causes gastric fundic gland-type hyperplastic polyps and chronic bleeding

A patient experienced gastric fundic gland-type hyperplastic polyps, consisting of foveolar epithelium and parietal cells, complicated with chronic bleeding due to long-term treatment with vonoprazan. The patient had progressive anemia, probably caused by bleeding from the polyps. After switching fr...

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Veröffentlicht in:Clinical journal of gastroenterology 2023-04, Vol.16 (2), p.159-163
Hauptverfasser: Goto, Chihiro, Okimoto, Kenichiro, Matsusaka, Keisuke, Matsumura, Tomoaki, Akizue, Naoki, Ohta, Yuki, Taida, Takashi, Saito, Keiko, Kato, Jun, Kato, Naoya
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Sprache:eng
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Zusammenfassung:A patient experienced gastric fundic gland-type hyperplastic polyps, consisting of foveolar epithelium and parietal cells, complicated with chronic bleeding due to long-term treatment with vonoprazan. The patient had progressive anemia, probably caused by bleeding from the polyps. After switching from vonoprazan to a histamine-2 (H2) receptor antagonist, the polyps markedly shrank and the anemia improved. Vonoprazan can produce reversible hyperplastic polyps and anemia. In case of anemia in patients receiving long-term vonoprazan, it is important to consider drug cessation or change to an H2 blocker.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-022-01751-0