Efficient delivery of VEGFA mRNA for promoting wound healing via ionizable lipid nanoparticles

VEGFA mRNA-LNP was translated into VEGFA protein in the body. The injected VEGFA mRNA-LNP was endocytosed by cells. After escaping the lysosome and entering the cytoplasm, VEGFA mRNA was translated into protein by ribosome. The translated protein can accelerate wound healing. [Display omitted] Vascu...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2023-01, Vol.78, p.117135-117135, Article 117135
Hauptverfasser:	Dong, Shuo, Wang, Ji, Guo, Zongke, Zhang, Yanhao, Zha, Wenhui, Wang, Yang, Liu, Chao, Xing, Hanlei, Li, Xinsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Human Umbilical Vein Endothelial Cells - metabolism Humans Ionizable lipid nanoparticle Mice Mice, Inbred C57BL Nanoparticles - chemistry Protein replacement RNA, Messenger - genetics Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism VEGFA mRNA Wound Healing
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