Are Fish Populations at Risk? Metformin Disrupts Zebrafish Development and Reproductive Processes at Chronic Environmentally Relevant Concentrations

The antidiabetic drug Metformin (MET), one of the most prevalent pharmaceuticals in the environment, is currently detected in surface waters in the range of ng/L to low μg/L. As current knowledge regarding the long-term effects of environmentally relevant concentrations of MET in nontarget organisms...

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Veröffentlicht in:	Environmental science & technology 2023-01, Vol.57 (2), p.1049-1059
Hauptverfasser:	Barros, Susana, Alves, Nélson, Pinheiro, Marlene, Ribeiro, Marta, Morais, Hugo, Montes, Rosa, Rodil, Rosario, Quintana, José Benito, Coimbra, Ana M., Santos, Miguel M., Neuparth, Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals At risk populations Biological activity Biosynthesis Danio rerio Diabetes mellitus Ecotoxicology and Public Health Embryogenesis Embryonic growth stage Environmental effects Environmental quality Estrogens Fertilization Fish populations Long-term effects Male Metabolism Metformin Metformin - toxicity Mode of action Nontarget organisms Offspring Parameter sensitivity Quality standards Reproduction Risk Factors Surface water Survival Water Pollutants, Chemical - toxicity Xenoestrogens Zebrafish
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