Trojan Horse Nanocapsule Enabled In Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice

Th17/Treg imbalance is closely related to the occurrence and development of multiple sclerosis (MS), and the transdifferentiation of Th17 cells into Treg cells may contribute to the resolution of inflammation, presenting a therapeutic strategy for MS. To modulate this phenotypic shift in situ, a “Tr...

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Veröffentlicht in:	Advanced materials (Weinheim) 2023-03, Vol.35 (11), p.e2210262-n/a
Hauptverfasser:	Shi, Chongdeng, Zhang, Jing, Wang, Huijun, Chen, Chen, Han, Maosen, Gao, Lin, Tang, Chunwei, Sun, Peng, Zhao, Xiaotian, Guo, Feiyue, Wang, Zhaozhong, Abdalla, Mohnad, Yang, Zhenmei, Liu, Ying, Li, Anning, Zhang, Cai, Jiang, Xinyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Animals Autoimmune diseases Blood-brain barrier cellular combination delivery systems CNS inflammation Conversion drug delivery Hybrid systems Materials science Mice Modulation Multiple sclerosis Multiple Sclerosis - drug therapy Nanocapsules Phenotype T-Lymphocytes, Regulatory - metabolism Th17 cells Th17 Cells - metabolism Treg cells
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