Non‐invasive prenatal testing for everybody or contingent screening?
Key points What's already known about this topic? Non‐invasive prenatal testing (NIPT) for fetal aneuploidies has been quickly implemented worldwide. Different implementation strategies are used for NIPT, either as a first‐tier screening test or as a contingent test after the first‐trimester sc...
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| Veröffentlicht in: | Prenatal diagnosis 2023-04, Vol.43 (4), p.443-447 |
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| container_title | Prenatal diagnosis |
| container_volume | 43 |
| creator | Meij, Karuna R. M. Henneman, Lidewij Sistermans, Erik A. |
| description | Key points
What's already known about this topic?
Non‐invasive prenatal testing (NIPT) for fetal aneuploidies has been quickly implemented worldwide.
Different implementation strategies are used for NIPT, either as a first‐tier screening test or as a contingent test after the first‐trimester screening.
What does this study add?
We argue that offering NIPT as a first‐tier test has several advantages over contingent NIPT:
No time window for testing.
Higher sensitivity or detection rate, thus fewer false negatives.
More women get a definitive result after a single test, less need for follow‐up tests.
Pregnant women prefer first‐tier NIPT. |
| doi_str_mv | 10.1002/pd.6296 |
| format | Article |
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What's already known about this topic?
Non‐invasive prenatal testing (NIPT) for fetal aneuploidies has been quickly implemented worldwide.
Different implementation strategies are used for NIPT, either as a first‐tier screening test or as a contingent test after the first‐trimester screening.
What does this study add?
We argue that offering NIPT as a first‐tier test has several advantages over contingent NIPT:
No time window for testing.
Higher sensitivity or detection rate, thus fewer false negatives.
More women get a definitive result after a single test, less need for follow‐up tests.
Pregnant women prefer first‐tier NIPT.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.6296</identifier><identifier>PMID: 36575900</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Down Syndrome - diagnosis ; Female ; Genetic Testing ; Humans ; Pregnancy ; Prenatal Diagnosis</subject><ispartof>Prenatal diagnosis, 2023-04, Vol.43 (4), p.443-447</ispartof><rights>2022 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3786-fef2c1fd33df50d0f27c99d5530bd7a73990f1f2340197adefb2e9048f43ec153</citedby><cites>FETCH-LOGICAL-c3786-fef2c1fd33df50d0f27c99d5530bd7a73990f1f2340197adefb2e9048f43ec153</cites><orcidid>0000-0003-3531-0597 ; 0000-0002-1801-588X ; 0000-0001-7187-4563</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.6296$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.6296$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36575900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meij, Karuna R. M.</creatorcontrib><creatorcontrib>Henneman, Lidewij</creatorcontrib><creatorcontrib>Sistermans, Erik A.</creatorcontrib><title>Non‐invasive prenatal testing for everybody or contingent screening?</title><title>Prenatal diagnosis</title><addtitle>Prenat Diagn</addtitle><description>Key points
What's already known about this topic?
Non‐invasive prenatal testing (NIPT) for fetal aneuploidies has been quickly implemented worldwide.
Different implementation strategies are used for NIPT, either as a first‐tier screening test or as a contingent test after the first‐trimester screening.
What does this study add?
We argue that offering NIPT as a first‐tier test has several advantages over contingent NIPT:
No time window for testing.
Higher sensitivity or detection rate, thus fewer false negatives.
More women get a definitive result after a single test, less need for follow‐up tests.
Pregnant women prefer first‐tier NIPT.</description><subject>Down Syndrome - diagnosis</subject><subject>Female</subject><subject>Genetic Testing</subject><subject>Humans</subject><subject>Pregnancy</subject><subject>Prenatal Diagnosis</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kM1Kw0AUhQdRbK3iG0jAhYK0zk_-ZiVSrQqiLnQ9JJk7kpLOxJmkkp2P4DP6JE7a6kJwde_hfhzOPQgdEjwhGNPzWk5iyuMtNCSYJ2NMKdtGQ0z8ztKIDNCec3MPppQnu2jA4iiJOMZDNHsw-uvjs9TLzJVLCGoLOmuyKmjANaV-DZSxASzBdrmRXeBFYXR_AN0ErrAA2ouLfbSjssrBwWaO0Mvs-nl6O75_vLmbXt6PC5ak8ViBogVRkjGpIiyxoknBuYwihnOZZAnjHCuiKAv76JkElVPgOExVyKAgERuh07Vvbc1b6yOKRekKqKpMg2mdoKu3aBrGHj3-g85Na7VPJ2iKCWYkTkJPnaypwhrnLChR23KR2U4QLPpqRS1FX60njzZ-bb4A-cv9dOmBszXwXlbQ_ecjnq5Wdt8HcYGb</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Meij, Karuna R. M.</creator><creator>Henneman, Lidewij</creator><creator>Sistermans, Erik A.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3531-0597</orcidid><orcidid>https://orcid.org/0000-0002-1801-588X</orcidid><orcidid>https://orcid.org/0000-0001-7187-4563</orcidid></search><sort><creationdate>202304</creationdate><title>Non‐invasive prenatal testing for everybody or contingent screening?</title><author>Meij, Karuna R. M. ; Henneman, Lidewij ; Sistermans, Erik A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3786-fef2c1fd33df50d0f27c99d5530bd7a73990f1f2340197adefb2e9048f43ec153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Down Syndrome - diagnosis</topic><topic>Female</topic><topic>Genetic Testing</topic><topic>Humans</topic><topic>Pregnancy</topic><topic>Prenatal Diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meij, Karuna R. M.</creatorcontrib><creatorcontrib>Henneman, Lidewij</creatorcontrib><creatorcontrib>Sistermans, Erik A.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meij, Karuna R. M.</au><au>Henneman, Lidewij</au><au>Sistermans, Erik A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non‐invasive prenatal testing for everybody or contingent screening?</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat Diagn</addtitle><date>2023-04</date><risdate>2023</risdate><volume>43</volume><issue>4</issue><spage>443</spage><epage>447</epage><pages>443-447</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><abstract>Key points
What's already known about this topic?
Non‐invasive prenatal testing (NIPT) for fetal aneuploidies has been quickly implemented worldwide.
Different implementation strategies are used for NIPT, either as a first‐tier screening test or as a contingent test after the first‐trimester screening.
What does this study add?
We argue that offering NIPT as a first‐tier test has several advantages over contingent NIPT:
No time window for testing.
Higher sensitivity or detection rate, thus fewer false negatives.
More women get a definitive result after a single test, less need for follow‐up tests.
Pregnant women prefer first‐tier NIPT.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36575900</pmid><doi>10.1002/pd.6296</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3531-0597</orcidid><orcidid>https://orcid.org/0000-0002-1801-588X</orcidid><orcidid>https://orcid.org/0000-0001-7187-4563</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-3851 |
| ispartof | Prenatal diagnosis, 2023-04, Vol.43 (4), p.443-447 |
| issn | 0197-3851 1097-0223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2759002846 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Down Syndrome - diagnosis Female Genetic Testing Humans Pregnancy Prenatal Diagnosis |
| title | Non‐invasive prenatal testing for everybody or contingent screening? |
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