$Expression of high molecular weight cytokeratin—A novel feature of aggressive and innate hormone‐refractory prostatic adenocarcinoma$

Expression of high molecular weight cytokeratin—A novel feature of aggressive and innate hormone‐refractory prostatic adenocarcinoma

Background Castration‐resistance is common in advanced prostatic adenocarcinomas (PACs) treated with androgen deprivation therapy (ADT) and usually occurs after 2 years following treatment. A minority of PACs confer innate ADT resistance without prior hormonal treatment. The expression of HMWCK in P...

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Veröffentlicht in:	The Prostate 2023-04, Vol.83 (5), p.462-469
Hauptverfasser:	Lu, Jiajie G., Lo, Emily T., Williams, Cleandrea, Ma, Brian, Sherrod, Andy E., Xiao, Guang‐Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenocarcinoma Adenocarcinoma - pathology Androgen Antagonists - therapeutic use Castration Comedones Cytokeratin Growth patterns high molecular weight cytokeratin hormonal resistance Hormones - therapeutic use Humans Keratins - therapeutic use Male MAP kinase Molecular Weight Neoplasm Recurrence, Local - drug therapy Nkx3.1 protein Phosphatidylinositol 3-Kinases Prostate cancer Prostatic Neoplasms - pathology PTEN protein Tumors
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