Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity
Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli‐responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design of a highly sensitive PEGylated photosensitizer‐peptide...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2022-09, Vol.61 (38), p.e202208732-n/a |
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| creator | Sun, Bingbing Guo, Xiaoping Feng, Mei Cao, Shoupeng Yang, Haowen Wu, Hanglong Stevendaal, Marleen H. M. E. Oerlemans, Roy A. J. F. Liang, Jinning Ouyang, Yiqiang Hest, Jan C. M. |
| description | Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli‐responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design of a highly sensitive PEGylated photosensitizer‐peptide nanofiber (termed PHHPEG6 NF) that selectively aggregates in the acidic tumor and lysosomal microenvironment. These nanofibers exhibit acid‐induced enhanced singlet oxygen generation, cellular uptake, and PDT efficacy in vitro, as well as fast tumor accumulation, long‐term tumor imaging capacity and effective PDT in vivo. Moreover, based on the prolonged presence of the fluorescent signal at the tumor site, we demonstrate that PHHPEG6 NFs can also be applied for prognostic monitoring of the efficacy of PDT in vivo, which would potentially guide cancer treatment. Therefore, these multifunctional PHHPEG6 NFs allow control over the entire PDT process, from visualization of photosensitizer accumulation, via actual PDT to the assessment of the efficacy of the treatment.
A PEGylated porphyrin‐peptide (PHHPEG6) building block self‐assembled into nanofibers (NFs), which formed aggregates in the acidic tumor microenvironment. The pH‐induced aggregation of PHHPEG6 NFs resulted in enhanced 1O2 generation efficiency and prolonged tumor retention, thus enabling control over the entire PDT process, from the visualization of photosensitizer accumulation to actual PDT and subsequent assessment of the efficacy of the treatment. |
| doi_str_mv | 10.1002/anie.202208732 |
| format | Article |
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A PEGylated porphyrin‐peptide (PHHPEG6) building block self‐assembled into nanofibers (NFs), which formed aggregates in the acidic tumor microenvironment. The pH‐induced aggregation of PHHPEG6 NFs resulted in enhanced 1O2 generation efficiency and prolonged tumor retention, thus enabling control over the entire PDT process, from the visualization of photosensitizer accumulation to actual PDT and subsequent assessment of the efficacy of the treatment.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>ISSN: 1521-3773</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.202208732</identifier><identifier>PMID: 36574602</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Accumulation ; Cancer ; Effectiveness ; Fluorescence ; Long-Term Tumor Retention ; Microenvironments ; Nanofibers ; Nanomaterials ; Nanotechnology ; Peptides ; Photodynamic Therapy ; Self-Assembly ; Singlet oxygen ; Tumors</subject><ispartof>Angewandte Chemie International Edition, 2022-09, Vol.61 (38), p.e202208732-n/a</ispartof><rights>2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH</rights><rights>2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4132-f6b74643daa9562446ba73702993828b44347081eb6a91c59ae45b47480a563</citedby><cites>FETCH-LOGICAL-c4132-f6b74643daa9562446ba73702993828b44347081eb6a91c59ae45b47480a563</cites><orcidid>0000-0002-4076-6233 ; 0000-0002-5856-2407 ; 0000-0001-8726-1294 ; 0000-0002-8042-9952 ; 0000-0002-3196-8917 ; 0000-0001-7973-2404 ; 0000-0002-9934-1248</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.202208732$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.202208732$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36574602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Bingbing</creatorcontrib><creatorcontrib>Guo, Xiaoping</creatorcontrib><creatorcontrib>Feng, Mei</creatorcontrib><creatorcontrib>Cao, Shoupeng</creatorcontrib><creatorcontrib>Yang, Haowen</creatorcontrib><creatorcontrib>Wu, Hanglong</creatorcontrib><creatorcontrib>Stevendaal, Marleen H. M. E.</creatorcontrib><creatorcontrib>Oerlemans, Roy A. J. F.</creatorcontrib><creatorcontrib>Liang, Jinning</creatorcontrib><creatorcontrib>Ouyang, Yiqiang</creatorcontrib><creatorcontrib>Hest, Jan C. M.</creatorcontrib><title>Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli‐responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design of a highly sensitive PEGylated photosensitizer‐peptide nanofiber (termed PHHPEG6 NF) that selectively aggregates in the acidic tumor and lysosomal microenvironment. These nanofibers exhibit acid‐induced enhanced singlet oxygen generation, cellular uptake, and PDT efficacy in vitro, as well as fast tumor accumulation, long‐term tumor imaging capacity and effective PDT in vivo. Moreover, based on the prolonged presence of the fluorescent signal at the tumor site, we demonstrate that PHHPEG6 NFs can also be applied for prognostic monitoring of the efficacy of PDT in vivo, which would potentially guide cancer treatment. Therefore, these multifunctional PHHPEG6 NFs allow control over the entire PDT process, from visualization of photosensitizer accumulation, via actual PDT to the assessment of the efficacy of the treatment.
A PEGylated porphyrin‐peptide (PHHPEG6) building block self‐assembled into nanofibers (NFs), which formed aggregates in the acidic tumor microenvironment. The pH‐induced aggregation of PHHPEG6 NFs resulted in enhanced 1O2 generation efficiency and prolonged tumor retention, thus enabling control over the entire PDT process, from the visualization of photosensitizer accumulation to actual PDT and subsequent assessment of the efficacy of the treatment.</description><subject>Accumulation</subject><subject>Cancer</subject><subject>Effectiveness</subject><subject>Fluorescence</subject><subject>Long-Term Tumor Retention</subject><subject>Microenvironments</subject><subject>Nanofibers</subject><subject>Nanomaterials</subject><subject>Nanotechnology</subject><subject>Peptides</subject><subject>Photodynamic Therapy</subject><subject>Self-Assembly</subject><subject>Singlet oxygen</subject><subject>Tumors</subject><issn>1433-7851</issn><issn>1521-3773</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNqFkM9PwjAUxxujEUSvHs0SL16G_d3uSAgoCVGi3Jtu66RkbLPdJPz3loCYePH0-ppPP-_1C8AtgkMEIX7UlTVDDDGGUhB8BvqIYRQTIch5OFNCYiEZ6oEr79eBlxLyS9AjnAnKIe6D6ZvxTV15-2WihWlam5voRVd1YVPjfLS17SparowLV761WaSrPFq4-uPYjnWjM9vursFFoUtvbo51AN6nk-X4OZ6_Ps3Go3mcUURwXPA0zKUk1zphHFPKUy2IgDhJiMQypZRQASUyKdcJyliiDWUpFVRCzTgZgIeDtXH1Z2d8qzbWZ6YsdWXqzissWBI-GVQBvf-DruvOVWG3QCEsBIIMBWp4oDJXe-9MoRpnN9rtFIJqn6_a56tO-YYHd0dtl25MfsJ_Ag1AcgC2tjS7f3Rq9DKb_Mq_AUkNhMs</recordid><startdate>20220919</startdate><enddate>20220919</enddate><creator>Sun, Bingbing</creator><creator>Guo, Xiaoping</creator><creator>Feng, Mei</creator><creator>Cao, Shoupeng</creator><creator>Yang, Haowen</creator><creator>Wu, Hanglong</creator><creator>Stevendaal, Marleen H. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2022-09-19</date><risdate>2022</risdate><volume>61</volume><issue>38</issue><spage>e202208732</spage><epage>n/a</epage><pages>e202208732-n/a</pages><issn>1433-7851</issn><issn>1521-3773</issn><eissn>1521-3773</eissn><abstract>Photodynamic therapy (PDT) is a highly promising therapeutic modality for cancer treatment. The development of stimuli‐responsive photosensitizer nanomaterials overcomes certain limitations in clinical PDT. Herein, we report the rational design of a highly sensitive PEGylated photosensitizer‐peptide nanofiber (termed PHHPEG6 NF) that selectively aggregates in the acidic tumor and lysosomal microenvironment. These nanofibers exhibit acid‐induced enhanced singlet oxygen generation, cellular uptake, and PDT efficacy in vitro, as well as fast tumor accumulation, long‐term tumor imaging capacity and effective PDT in vivo. Moreover, based on the prolonged presence of the fluorescent signal at the tumor site, we demonstrate that PHHPEG6 NFs can also be applied for prognostic monitoring of the efficacy of PDT in vivo, which would potentially guide cancer treatment. Therefore, these multifunctional PHHPEG6 NFs allow control over the entire PDT process, from visualization of photosensitizer accumulation, via actual PDT to the assessment of the efficacy of the treatment.
A PEGylated porphyrin‐peptide (PHHPEG6) building block self‐assembled into nanofibers (NFs), which formed aggregates in the acidic tumor microenvironment. The pH‐induced aggregation of PHHPEG6 NFs resulted in enhanced 1O2 generation efficiency and prolonged tumor retention, thus enabling control over the entire PDT process, from the visualization of photosensitizer accumulation to actual PDT and subsequent assessment of the efficacy of the treatment.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36574602</pmid><doi>10.1002/anie.202208732</doi><tpages>9</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-4076-6233</orcidid><orcidid>https://orcid.org/0000-0002-5856-2407</orcidid><orcidid>https://orcid.org/0000-0001-8726-1294</orcidid><orcidid>https://orcid.org/0000-0002-8042-9952</orcidid><orcidid>https://orcid.org/0000-0002-3196-8917</orcidid><orcidid>https://orcid.org/0000-0001-7973-2404</orcidid><orcidid>https://orcid.org/0000-0002-9934-1248</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Accumulation Cancer Effectiveness Fluorescence Long-Term Tumor Retention Microenvironments Nanofibers Nanomaterials Nanotechnology Peptides Photodynamic Therapy Self-Assembly Singlet oxygen Tumors |
| title | Responsive Peptide Nanofibers with Theranostic and Prognostic Capacity |
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