Expression dynamics of lymphoid enhancer‐binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis
Background Transcription factor lymphoid enhancer‐binding factor 1 (LEF1) is a downstream mediator of the Wnt/β‐catenin signaling pathway. It is expressed in dermal papilla and surrounding cells in the hair follicle, promoting cell proliferation, and differentiation. Results Here, we report that LEF...
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| Veröffentlicht in: | Developmental dynamics 2023-04, Vol.252 (4), p.527-535 |
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| creator | Song, Hongzhi Zhao, Xu‐Bo Chu, Qing‐Song Zhang, Jianyu Gao, Lipeng Liao, Xin‐Hua |
| description | Background
Transcription factor lymphoid enhancer‐binding factor 1 (LEF1) is a downstream mediator of the Wnt/β‐catenin signaling pathway. It is expressed in dermal papilla and surrounding cells in the hair follicle, promoting cell proliferation, and differentiation.
Results
Here, we report that LEF1 is also expressed all through the hair cycle in the terminal Schwann cells (TSCs), a component of the lanceolate complex located at the isthmus. The timing of LEF1 appearance at the isthmus coincides with that of hair follicle innervation. LEF1 is not found at the isthmus in the aberrant hair follicles in nude mice. Instead, LEF1 in TSCs is found in the de novo hair follicles reconstituted on nude mice by stem cells chamber graft assay. Cutaneous denervation experiment demonstrates that the LEF1 expression in TSCs is independent of nerve endings. At last, LEF1 expression in the interfollicular epidermis during the early stage of skin development is significantly suppressed in transgenic mice with T‐cell factor 3 (TCF3) overexpression.
Conclusion
We reveal the expression dynamics of LEF1 in skin during development and hair cycle. LEF1 expression in TSCs indicates that the LEF1/Wnt signal might help to establish a niche at the isthmus region for the lanceolate complex, the bulge stem cells and other neighboring cells.
Key Findings
LEF1 is expressed in the terminal Schwann cells (TSCs) surrounding the hair follicle isthmus.
LEF1 expression in TSCs is independent of nerve endings.
LEF1 expression in the interfollicular epidermis is suppressed by overexpression of TCF3.
LEF1+ TSCs might constitute a Wnt‐active niche at the isthmus region. |
| doi_str_mv | 10.1002/dvdy.562 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2759000781</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2759000781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3102-101b02daf783592ddec4770e4b92cbbc4869796f173c2fbeb4924551597ae6673</originalsourceid><addsrcrecordid>eNp10ctqHSEcBnAJDblDn6AI3XRx5kSdcdRlyR0CWaQNZDU46vQYHJ3qmaSzyyIPkGfMk8QhaSmFrpQ_Pz4vHwAfMVpihMihvtfTktZkA-xgJFiBMGMf5j3lBS853wa7Kd0hhHhd4S2wXdaU1YzQHfB08muIJiUbPNSTl71VCYYOuqkfVsFqaPxKemXiy-Nza722_gfspFqHCDG0Hq5N7K2XDl6r1YP0HirjXFpAned5OsjBOicXUHqdedZdcM6q0ckIzWBnZtM-2OykS-bgfd0D309Pvh2dF5dXZxdHXy8LVWJECoxwi4iWHeMlFURroyrGkKlaQVTbqorXgom6w6xUpGtNWwlSUYqpYNLUNSv3wJe33CGGn6NJ6yYfPl9YehPG1BBGRf4kxnGmn_-hd2GM-aGzEiUlnNO_AlUMKUXTNUO0vYxTg1EzN9PMzTS5mUw_vQeObW_0H_i7igyKN_BgnZn-G9Qc3xzfzoGvFNeaJQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2793528857</pqid></control><display><type>article</type><title>Expression dynamics of lymphoid enhancer‐binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Song, Hongzhi ; Zhao, Xu‐Bo ; Chu, Qing‐Song ; Zhang, Jianyu ; Gao, Lipeng ; Liao, Xin‐Hua</creator><creatorcontrib>Song, Hongzhi ; Zhao, Xu‐Bo ; Chu, Qing‐Song ; Zhang, Jianyu ; Gao, Lipeng ; Liao, Xin‐Hua</creatorcontrib><description>Background
Transcription factor lymphoid enhancer‐binding factor 1 (LEF1) is a downstream mediator of the Wnt/β‐catenin signaling pathway. It is expressed in dermal papilla and surrounding cells in the hair follicle, promoting cell proliferation, and differentiation.
Results
Here, we report that LEF1 is also expressed all through the hair cycle in the terminal Schwann cells (TSCs), a component of the lanceolate complex located at the isthmus. The timing of LEF1 appearance at the isthmus coincides with that of hair follicle innervation. LEF1 is not found at the isthmus in the aberrant hair follicles in nude mice. Instead, LEF1 in TSCs is found in the de novo hair follicles reconstituted on nude mice by stem cells chamber graft assay. Cutaneous denervation experiment demonstrates that the LEF1 expression in TSCs is independent of nerve endings. At last, LEF1 expression in the interfollicular epidermis during the early stage of skin development is significantly suppressed in transgenic mice with T‐cell factor 3 (TCF3) overexpression.
Conclusion
We reveal the expression dynamics of LEF1 in skin during development and hair cycle. LEF1 expression in TSCs indicates that the LEF1/Wnt signal might help to establish a niche at the isthmus region for the lanceolate complex, the bulge stem cells and other neighboring cells.
Key Findings
LEF1 is expressed in the terminal Schwann cells (TSCs) surrounding the hair follicle isthmus.
LEF1 expression in TSCs is independent of nerve endings.
LEF1 expression in the interfollicular epidermis is suppressed by overexpression of TCF3.
LEF1+ TSCs might constitute a Wnt‐active niche at the isthmus region.</description><identifier>ISSN: 1058-8388</identifier><identifier>EISSN: 1097-0177</identifier><identifier>DOI: 10.1002/dvdy.562</identifier><identifier>PMID: 36576725</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; beta Catenin - metabolism ; Binding ; Cell differentiation ; Cell proliferation ; Denervation ; dermal papilla ; Epidermis ; Epidermis - metabolism ; Follicles ; Hair ; Hair Follicle ; Innervation ; lanceolate complex ; LEF1 ; Lymphoid Enhancer-Binding Factor 1 - genetics ; Lymphoid Enhancer-Binding Factor 1 - metabolism ; Mice ; Mice, Nude ; Mice, Transgenic ; Nerve endings ; Schwann Cells ; Signal transduction ; SKPs ; stem cell niche ; Stem cells ; TCF3 ; Transgenic mice ; Wnt protein</subject><ispartof>Developmental dynamics, 2023-04, Vol.252 (4), p.527-535</ispartof><rights>2022 American Association of Anatomists.</rights><rights>2023 American Association for Anatomy</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3102-101b02daf783592ddec4770e4b92cbbc4869796f173c2fbeb4924551597ae6673</cites><orcidid>0000-0001-7520-7135</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdvdy.562$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdvdy.562$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36576725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Hongzhi</creatorcontrib><creatorcontrib>Zhao, Xu‐Bo</creatorcontrib><creatorcontrib>Chu, Qing‐Song</creatorcontrib><creatorcontrib>Zhang, Jianyu</creatorcontrib><creatorcontrib>Gao, Lipeng</creatorcontrib><creatorcontrib>Liao, Xin‐Hua</creatorcontrib><title>Expression dynamics of lymphoid enhancer‐binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis</title><title>Developmental dynamics</title><addtitle>Dev Dyn</addtitle><description>Background
Transcription factor lymphoid enhancer‐binding factor 1 (LEF1) is a downstream mediator of the Wnt/β‐catenin signaling pathway. It is expressed in dermal papilla and surrounding cells in the hair follicle, promoting cell proliferation, and differentiation.
Results
Here, we report that LEF1 is also expressed all through the hair cycle in the terminal Schwann cells (TSCs), a component of the lanceolate complex located at the isthmus. The timing of LEF1 appearance at the isthmus coincides with that of hair follicle innervation. LEF1 is not found at the isthmus in the aberrant hair follicles in nude mice. Instead, LEF1 in TSCs is found in the de novo hair follicles reconstituted on nude mice by stem cells chamber graft assay. Cutaneous denervation experiment demonstrates that the LEF1 expression in TSCs is independent of nerve endings. At last, LEF1 expression in the interfollicular epidermis during the early stage of skin development is significantly suppressed in transgenic mice with T‐cell factor 3 (TCF3) overexpression.
Conclusion
We reveal the expression dynamics of LEF1 in skin during development and hair cycle. LEF1 expression in TSCs indicates that the LEF1/Wnt signal might help to establish a niche at the isthmus region for the lanceolate complex, the bulge stem cells and other neighboring cells.
Key Findings
LEF1 is expressed in the terminal Schwann cells (TSCs) surrounding the hair follicle isthmus.
LEF1 expression in TSCs is independent of nerve endings.
LEF1 expression in the interfollicular epidermis is suppressed by overexpression of TCF3.
LEF1+ TSCs might constitute a Wnt‐active niche at the isthmus region.</description><subject>Animals</subject><subject>beta Catenin - metabolism</subject><subject>Binding</subject><subject>Cell differentiation</subject><subject>Cell proliferation</subject><subject>Denervation</subject><subject>dermal papilla</subject><subject>Epidermis</subject><subject>Epidermis - metabolism</subject><subject>Follicles</subject><subject>Hair</subject><subject>Hair Follicle</subject><subject>Innervation</subject><subject>lanceolate complex</subject><subject>LEF1</subject><subject>Lymphoid Enhancer-Binding Factor 1 - genetics</subject><subject>Lymphoid Enhancer-Binding Factor 1 - metabolism</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Mice, Transgenic</subject><subject>Nerve endings</subject><subject>Schwann Cells</subject><subject>Signal transduction</subject><subject>SKPs</subject><subject>stem cell niche</subject><subject>Stem cells</subject><subject>TCF3</subject><subject>Transgenic mice</subject><subject>Wnt protein</subject><issn>1058-8388</issn><issn>1097-0177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctqHSEcBnAJDblDn6AI3XRx5kSdcdRlyR0CWaQNZDU46vQYHJ3qmaSzyyIPkGfMk8QhaSmFrpQ_Pz4vHwAfMVpihMihvtfTktZkA-xgJFiBMGMf5j3lBS853wa7Kd0hhHhd4S2wXdaU1YzQHfB08muIJiUbPNSTl71VCYYOuqkfVsFqaPxKemXiy-Nza722_gfspFqHCDG0Hq5N7K2XDl6r1YP0HirjXFpAned5OsjBOicXUHqdedZdcM6q0ckIzWBnZtM-2OykS-bgfd0D309Pvh2dF5dXZxdHXy8LVWJECoxwi4iWHeMlFURroyrGkKlaQVTbqorXgom6w6xUpGtNWwlSUYqpYNLUNSv3wJe33CGGn6NJ6yYfPl9YehPG1BBGRf4kxnGmn_-hd2GM-aGzEiUlnNO_AlUMKUXTNUO0vYxTg1EzN9PMzTS5mUw_vQeObW_0H_i7igyKN_BgnZn-G9Qc3xzfzoGvFNeaJQ</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Song, Hongzhi</creator><creator>Zhao, Xu‐Bo</creator><creator>Chu, Qing‐Song</creator><creator>Zhang, Jianyu</creator><creator>Gao, Lipeng</creator><creator>Liao, Xin‐Hua</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>JQ2</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7520-7135</orcidid></search><sort><creationdate>202304</creationdate><title>Expression dynamics of lymphoid enhancer‐binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis</title><author>Song, Hongzhi ; Zhao, Xu‐Bo ; Chu, Qing‐Song ; Zhang, Jianyu ; Gao, Lipeng ; Liao, Xin‐Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3102-101b02daf783592ddec4770e4b92cbbc4869796f173c2fbeb4924551597ae6673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>beta Catenin - metabolism</topic><topic>Binding</topic><topic>Cell differentiation</topic><topic>Cell proliferation</topic><topic>Denervation</topic><topic>dermal papilla</topic><topic>Epidermis</topic><topic>Epidermis - metabolism</topic><topic>Follicles</topic><topic>Hair</topic><topic>Hair Follicle</topic><topic>Innervation</topic><topic>lanceolate complex</topic><topic>LEF1</topic><topic>Lymphoid Enhancer-Binding Factor 1 - genetics</topic><topic>Lymphoid Enhancer-Binding Factor 1 - metabolism</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Mice, Transgenic</topic><topic>Nerve endings</topic><topic>Schwann Cells</topic><topic>Signal transduction</topic><topic>SKPs</topic><topic>stem cell niche</topic><topic>Stem cells</topic><topic>TCF3</topic><topic>Transgenic mice</topic><topic>Wnt protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Hongzhi</creatorcontrib><creatorcontrib>Zhao, Xu‐Bo</creatorcontrib><creatorcontrib>Chu, Qing‐Song</creatorcontrib><creatorcontrib>Zhang, Jianyu</creatorcontrib><creatorcontrib>Gao, Lipeng</creatorcontrib><creatorcontrib>Liao, Xin‐Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Hongzhi</au><au>Zhao, Xu‐Bo</au><au>Chu, Qing‐Song</au><au>Zhang, Jianyu</au><au>Gao, Lipeng</au><au>Liao, Xin‐Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression dynamics of lymphoid enhancer‐binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis</atitle><jtitle>Developmental dynamics</jtitle><addtitle>Dev Dyn</addtitle><date>2023-04</date><risdate>2023</risdate><volume>252</volume><issue>4</issue><spage>527</spage><epage>535</epage><pages>527-535</pages><issn>1058-8388</issn><eissn>1097-0177</eissn><abstract>Background
Transcription factor lymphoid enhancer‐binding factor 1 (LEF1) is a downstream mediator of the Wnt/β‐catenin signaling pathway. It is expressed in dermal papilla and surrounding cells in the hair follicle, promoting cell proliferation, and differentiation.
Results
Here, we report that LEF1 is also expressed all through the hair cycle in the terminal Schwann cells (TSCs), a component of the lanceolate complex located at the isthmus. The timing of LEF1 appearance at the isthmus coincides with that of hair follicle innervation. LEF1 is not found at the isthmus in the aberrant hair follicles in nude mice. Instead, LEF1 in TSCs is found in the de novo hair follicles reconstituted on nude mice by stem cells chamber graft assay. Cutaneous denervation experiment demonstrates that the LEF1 expression in TSCs is independent of nerve endings. At last, LEF1 expression in the interfollicular epidermis during the early stage of skin development is significantly suppressed in transgenic mice with T‐cell factor 3 (TCF3) overexpression.
Conclusion
We reveal the expression dynamics of LEF1 in skin during development and hair cycle. LEF1 expression in TSCs indicates that the LEF1/Wnt signal might help to establish a niche at the isthmus region for the lanceolate complex, the bulge stem cells and other neighboring cells.
Key Findings
LEF1 is expressed in the terminal Schwann cells (TSCs) surrounding the hair follicle isthmus.
LEF1 expression in TSCs is independent of nerve endings.
LEF1 expression in the interfollicular epidermis is suppressed by overexpression of TCF3.
LEF1+ TSCs might constitute a Wnt‐active niche at the isthmus region.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>36576725</pmid><doi>10.1002/dvdy.562</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7520-7135</orcidid></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals beta Catenin - metabolism Binding Cell differentiation Cell proliferation Denervation dermal papilla Epidermis Epidermis - metabolism Follicles Hair Hair Follicle Innervation lanceolate complex LEF1 Lymphoid Enhancer-Binding Factor 1 - genetics Lymphoid Enhancer-Binding Factor 1 - metabolism Mice Mice, Nude Mice, Transgenic Nerve endings Schwann Cells Signal transduction SKPs stem cell niche Stem cells TCF3 Transgenic mice Wnt protein |
| title | Expression dynamics of lymphoid enhancer‐binding factor 1 in terminal Schwann cells, dermal papilla, and interfollicular epidermis |
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