Clinical and experimental evidence for transplacental vertical transmission of flaviviruses
The Zika virus (ZIKV) epidemic outbreak in Americas in 2016 attracted global attention because of the association of the virus infection with severe birth defects such as microcephaly, mediated through transplacental virus transmission during pregnancy. Less well-known, but also reported is the incr...
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| Veröffentlicht in: | Antiviral research 2023-02, Vol.210, p.105512-105512, Article 105512 |
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| container_title | Antiviral research |
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| creator | Watanabe, Satoru Vasudevan, Subhash G. |
| description | The Zika virus (ZIKV) epidemic outbreak in Americas in 2016 attracted global attention because of the association of the virus infection with severe birth defects such as microcephaly, mediated through transplacental virus transmission during pregnancy. Less well-known, but also reported is the increasing evidence that prenatal vertical transmission can be caused by other flaviviruses such as dengue virus (DENV). Currently, the mechanism(s) that cause the vertical transmission of flaviviruses is understudied. Here we review the published reports of clinical evidence of intrauterine transmission of ZIKV and other flaviviruses. We also discuss the animal models for flavivirus infection during pregnancy that have been developed to study the mechanisms underlying the transplacental transmission of flaviviruses in order to develop potential countermeasures for its prevention.
•Clinical evidence of transplacental transmission of ZIKV, DENV and other flaviviruses is reviewed.•ZIKV transplacental transmission causes microcephaly and other congenital abnormalities.•Transplacental transmission from mother to fetus/infant also reported for DENV, JEV, WNV and YFV.•Animal models of flavivirus infection during pregnancy enables mechanistic study of transplacental transmission. |
| doi_str_mv | 10.1016/j.antiviral.2022.105512 |
| format | Article |
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•Clinical evidence of transplacental transmission of ZIKV, DENV and other flaviviruses is reviewed.•ZIKV transplacental transmission causes microcephaly and other congenital abnormalities.•Transplacental transmission from mother to fetus/infant also reported for DENV, JEV, WNV and YFV.•Animal models of flavivirus infection during pregnancy enables mechanistic study of transplacental transmission.</description><identifier>ISSN: 0166-3542</identifier><identifier>EISSN: 1872-9096</identifier><identifier>DOI: 10.1016/j.antiviral.2022.105512</identifier><identifier>PMID: 36572192</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Clinical observation ; Dengue ; Dengue Virus ; Female ; Flavivirus ; Flavivirus Infections ; Pregnancy ; Pregnant animal model ; Vertical transmission ; Zika Virus ; Zika Virus Infection</subject><ispartof>Antiviral research, 2023-02, Vol.210, p.105512-105512, Article 105512</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-6eaf1b8212373b6cffb84933ab4349a23669d5511d13543495cd4d1a537bf29f3</citedby><cites>FETCH-LOGICAL-c301t-6eaf1b8212373b6cffb84933ab4349a23669d5511d13543495cd4d1a537bf29f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.antiviral.2022.105512$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36572192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Satoru</creatorcontrib><creatorcontrib>Vasudevan, Subhash G.</creatorcontrib><title>Clinical and experimental evidence for transplacental vertical transmission of flaviviruses</title><title>Antiviral research</title><addtitle>Antiviral Res</addtitle><description>The Zika virus (ZIKV) epidemic outbreak in Americas in 2016 attracted global attention because of the association of the virus infection with severe birth defects such as microcephaly, mediated through transplacental virus transmission during pregnancy. Less well-known, but also reported is the increasing evidence that prenatal vertical transmission can be caused by other flaviviruses such as dengue virus (DENV). Currently, the mechanism(s) that cause the vertical transmission of flaviviruses is understudied. Here we review the published reports of clinical evidence of intrauterine transmission of ZIKV and other flaviviruses. We also discuss the animal models for flavivirus infection during pregnancy that have been developed to study the mechanisms underlying the transplacental transmission of flaviviruses in order to develop potential countermeasures for its prevention.
•Clinical evidence of transplacental transmission of ZIKV, DENV and other flaviviruses is reviewed.•ZIKV transplacental transmission causes microcephaly and other congenital abnormalities.•Transplacental transmission from mother to fetus/infant also reported for DENV, JEV, WNV and YFV.•Animal models of flavivirus infection during pregnancy enables mechanistic study of transplacental transmission.</description><subject>Animals</subject><subject>Clinical observation</subject><subject>Dengue</subject><subject>Dengue Virus</subject><subject>Female</subject><subject>Flavivirus</subject><subject>Flavivirus Infections</subject><subject>Pregnancy</subject><subject>Pregnant animal model</subject><subject>Vertical transmission</subject><subject>Zika Virus</subject><subject>Zika Virus Infection</subject><issn>0166-3542</issn><issn>1872-9096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EoqXwFyBHLil-JHZ8rCpeUiUucOJgOfZacpUmxU4j-Pe4TemVk6XxzO7Oh9AdwXOCCX9Yz3Xb-8EH3cwppjSpZUnoGZqSStBcYsnP0TQ5ec7Kgk7QVYxrjDEXsrpEE8ZLQYmkU_S5bHzrjW4y3doMvrcQ_AbaPgkweAutgcx1IeuDbuO20Wb8GyD0h9RB3_gYfddmnctco4f9XbsI8RpdON1EuDm-M_Tx9Pi-fMlXb8-vy8UqNwyTPuegHakrSigTrObGuboqJGO6LlghNWWcS5vaEUtSlySVxhaW6JKJ2lHp2Azdj3O3ofvaQexVOshA0-gWul1UVJRVKQStZLKK0WpCF2MAp7aprw4_imC1J6vW6kRW7cmqkWxK3h6X7OoN2FPuD2UyLEYDpKqDh6Ci8Xt-1gcwvbKd_3fJL1P8j8E</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Watanabe, Satoru</creator><creator>Vasudevan, Subhash G.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202302</creationdate><title>Clinical and experimental evidence for transplacental vertical transmission of flaviviruses</title><author>Watanabe, Satoru ; Vasudevan, Subhash G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-6eaf1b8212373b6cffb84933ab4349a23669d5511d13543495cd4d1a537bf29f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Clinical observation</topic><topic>Dengue</topic><topic>Dengue Virus</topic><topic>Female</topic><topic>Flavivirus</topic><topic>Flavivirus Infections</topic><topic>Pregnancy</topic><topic>Pregnant animal model</topic><topic>Vertical transmission</topic><topic>Zika Virus</topic><topic>Zika Virus Infection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, Satoru</creatorcontrib><creatorcontrib>Vasudevan, Subhash G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Antiviral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Satoru</au><au>Vasudevan, Subhash G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and experimental evidence for transplacental vertical transmission of flaviviruses</atitle><jtitle>Antiviral research</jtitle><addtitle>Antiviral Res</addtitle><date>2023-02</date><risdate>2023</risdate><volume>210</volume><spage>105512</spage><epage>105512</epage><pages>105512-105512</pages><artnum>105512</artnum><issn>0166-3542</issn><eissn>1872-9096</eissn><abstract>The Zika virus (ZIKV) epidemic outbreak in Americas in 2016 attracted global attention because of the association of the virus infection with severe birth defects such as microcephaly, mediated through transplacental virus transmission during pregnancy. Less well-known, but also reported is the increasing evidence that prenatal vertical transmission can be caused by other flaviviruses such as dengue virus (DENV). Currently, the mechanism(s) that cause the vertical transmission of flaviviruses is understudied. Here we review the published reports of clinical evidence of intrauterine transmission of ZIKV and other flaviviruses. We also discuss the animal models for flavivirus infection during pregnancy that have been developed to study the mechanisms underlying the transplacental transmission of flaviviruses in order to develop potential countermeasures for its prevention.
•Clinical evidence of transplacental transmission of ZIKV, DENV and other flaviviruses is reviewed.•ZIKV transplacental transmission causes microcephaly and other congenital abnormalities.•Transplacental transmission from mother to fetus/infant also reported for DENV, JEV, WNV and YFV.•Animal models of flavivirus infection during pregnancy enables mechanistic study of transplacental transmission.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36572192</pmid><doi>10.1016/j.antiviral.2022.105512</doi><tpages>1</tpages></addata></record> |
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| identifier | ISSN: 0166-3542 |
| ispartof | Antiviral research, 2023-02, Vol.210, p.105512-105512, Article 105512 |
| issn | 0166-3542 1872-9096 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Clinical observation Dengue Dengue Virus Female Flavivirus Flavivirus Infections Pregnancy Pregnant animal model Vertical transmission Zika Virus Zika Virus Infection |
| title | Clinical and experimental evidence for transplacental vertical transmission of flaviviruses |
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