LEP and LEPR are possibly a double‐edged sword for wound healing
Wound healing is a complex and error‐prone process. Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form when the wound‐healing process goes wrong. Leptin (Lep) and leptin receptors (LepRs) h...
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| Veröffentlicht in: | Journal of cellular physiology 2023-02, Vol.238 (2), p.355-365 |
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| container_title | Journal of cellular physiology |
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| creator | Zhang, Kai‐Wen Jia, Yuan Li, Yue‐Yue Guo, Dan‐Yang Li, Xiao‐Xiao Hu, Kai Qian, Xiao‐Xi Chen, Zhong‐Hua Wu, Jun‐Jie Yuan, Zheng‐Dong Yuan, Feng‐Lai |
| description | Wound healing is a complex and error‐prone process. Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form when the wound‐healing process goes wrong. Leptin (Lep) and leptin receptors (LepRs) have recently been shown to affect multiple stages of wound healing. This effect, however, is paradoxical for scarless wound healing. On the one hand, Lep exerts pro‐inflammatory and profibrotic effects; on the other hand, Lep can regulate hair follicle growth. This paper summarises the role of Lep and LepRs on cells in different stages of wound healing, briefly introduces the process of wound healing and Lep and LepRs, and examines the possibility of promoting scarless wound healing through spatiotemporal, systemic, and local regulation of Lep levels and the binding of Lep and LepRs. |
| doi_str_mv | 10.1002/jcp.30936 |
| format | Article |
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Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form when the wound‐healing process goes wrong. Leptin (Lep) and leptin receptors (LepRs) have recently been shown to affect multiple stages of wound healing. This effect, however, is paradoxical for scarless wound healing. On the one hand, Lep exerts pro‐inflammatory and profibrotic effects; on the other hand, Lep can regulate hair follicle growth. This paper summarises the role of Lep and LepRs on cells in different stages of wound healing, briefly introduces the process of wound healing and Lep and LepRs, and examines the possibility of promoting scarless wound healing through spatiotemporal, systemic, and local regulation of Lep levels and the binding of Lep and LepRs.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.30936</identifier><identifier>PMID: 36571294</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Appendages ; Cicatrix, Hypertrophic - pathology ; Humans ; Inflammation ; leptin ; Leptin - metabolism ; leptin receptor ; Leptin receptors ; Receptors, Leptin - metabolism ; scar ; Scars ; skin ; Skin - metabolism ; Wound Healing</subject><ispartof>Journal of cellular physiology, 2023-02, Vol.238 (2), p.355-365</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-b5733f403c4d72a7d68e54bc667c1f93de81e331638dc1636520a8a63b7a75553</citedby><cites>FETCH-LOGICAL-c3886-b5733f403c4d72a7d68e54bc667c1f93de81e331638dc1636520a8a63b7a75553</cites><orcidid>0000-0003-2141-3122</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.30936$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.30936$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36571294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Kai‐Wen</creatorcontrib><creatorcontrib>Jia, Yuan</creatorcontrib><creatorcontrib>Li, Yue‐Yue</creatorcontrib><creatorcontrib>Guo, Dan‐Yang</creatorcontrib><creatorcontrib>Li, Xiao‐Xiao</creatorcontrib><creatorcontrib>Hu, Kai</creatorcontrib><creatorcontrib>Qian, Xiao‐Xi</creatorcontrib><creatorcontrib>Chen, Zhong‐Hua</creatorcontrib><creatorcontrib>Wu, Jun‐Jie</creatorcontrib><creatorcontrib>Yuan, Zheng‐Dong</creatorcontrib><creatorcontrib>Yuan, Feng‐Lai</creatorcontrib><title>LEP and LEPR are possibly a double‐edged sword for wound healing</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Wound healing is a complex and error‐prone process. Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form when the wound‐healing process goes wrong. Leptin (Lep) and leptin receptors (LepRs) have recently been shown to affect multiple stages of wound healing. This effect, however, is paradoxical for scarless wound healing. On the one hand, Lep exerts pro‐inflammatory and profibrotic effects; on the other hand, Lep can regulate hair follicle growth. This paper summarises the role of Lep and LepRs on cells in different stages of wound healing, briefly introduces the process of wound healing and Lep and LepRs, and examines the possibility of promoting scarless wound healing through spatiotemporal, systemic, and local regulation of Lep levels and the binding of Lep and LepRs.</description><subject>Animals</subject><subject>Appendages</subject><subject>Cicatrix, Hypertrophic - pathology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>leptin</subject><subject>Leptin - metabolism</subject><subject>leptin receptor</subject><subject>Leptin receptors</subject><subject>Receptors, Leptin - metabolism</subject><subject>scar</subject><subject>Scars</subject><subject>skin</subject><subject>Skin - metabolism</subject><subject>Wound Healing</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10LtOwzAUBmALgWgpDLwAssQCQ1o7ji8ZoSo3VaJCMFuO7ZRUaVxsoqobj8Az8iQYUhiQWHwGf_7l8wNwjNEQI5SOFno1JCgnbAf0Mcp5kjGa7oJ-vMNJTjPcAwchLBBCeU7IPugRRjlO86wPLqeTGVSNgXE-QOUtXLkQqqLeQAWNa4vafry9WzO3Boa18waWzsO1a-OTZ6vqqpkfgr1S1cEebecAPF1NHsc3yfT--nZ8MU00EYIlBeWElBkiOjM8VdwwYWlWaMa4xmVOjBXYEoIZEUbHM66AlFCMFFxxSikZgLMud-XdS2vDq1xWQdu6Vo11bZApp4JQlgoU6ekfunCtb-LvouKCUZRRFtV5p7SPO3tbypWvlspvJEbyq1gZi5XfxUZ7sk1si6U1v_KnyQhGHVhXtd38nyTvxrMu8hO7Jn9Z</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Zhang, Kai‐Wen</creator><creator>Jia, Yuan</creator><creator>Li, Yue‐Yue</creator><creator>Guo, Dan‐Yang</creator><creator>Li, Xiao‐Xiao</creator><creator>Hu, Kai</creator><creator>Qian, Xiao‐Xi</creator><creator>Chen, Zhong‐Hua</creator><creator>Wu, Jun‐Jie</creator><creator>Yuan, Zheng‐Dong</creator><creator>Yuan, Feng‐Lai</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2141-3122</orcidid></search><sort><creationdate>202302</creationdate><title>LEP and LEPR are possibly a double‐edged sword for wound healing</title><author>Zhang, Kai‐Wen ; Jia, Yuan ; Li, Yue‐Yue ; Guo, Dan‐Yang ; Li, Xiao‐Xiao ; Hu, Kai ; Qian, Xiao‐Xi ; Chen, Zhong‐Hua ; Wu, Jun‐Jie ; Yuan, Zheng‐Dong ; Yuan, Feng‐Lai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-b5733f403c4d72a7d68e54bc667c1f93de81e331638dc1636520a8a63b7a75553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Appendages</topic><topic>Cicatrix, Hypertrophic - pathology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>leptin</topic><topic>Leptin - metabolism</topic><topic>leptin receptor</topic><topic>Leptin receptors</topic><topic>Receptors, Leptin - metabolism</topic><topic>scar</topic><topic>Scars</topic><topic>skin</topic><topic>Skin - metabolism</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Kai‐Wen</creatorcontrib><creatorcontrib>Jia, Yuan</creatorcontrib><creatorcontrib>Li, Yue‐Yue</creatorcontrib><creatorcontrib>Guo, Dan‐Yang</creatorcontrib><creatorcontrib>Li, Xiao‐Xiao</creatorcontrib><creatorcontrib>Hu, Kai</creatorcontrib><creatorcontrib>Qian, Xiao‐Xi</creatorcontrib><creatorcontrib>Chen, Zhong‐Hua</creatorcontrib><creatorcontrib>Wu, Jun‐Jie</creatorcontrib><creatorcontrib>Yuan, Zheng‐Dong</creatorcontrib><creatorcontrib>Yuan, Feng‐Lai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Kai‐Wen</au><au>Jia, Yuan</au><au>Li, Yue‐Yue</au><au>Guo, Dan‐Yang</au><au>Li, Xiao‐Xiao</au><au>Hu, Kai</au><au>Qian, Xiao‐Xi</au><au>Chen, Zhong‐Hua</au><au>Wu, Jun‐Jie</au><au>Yuan, Zheng‐Dong</au><au>Yuan, Feng‐Lai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LEP and LEPR are possibly a double‐edged sword for wound healing</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2023-02</date><risdate>2023</risdate><volume>238</volume><issue>2</issue><spage>355</spage><epage>365</epage><pages>355-365</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Wound healing is a complex and error‐prone process. Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form when the wound‐healing process goes wrong. Leptin (Lep) and leptin receptors (LepRs) have recently been shown to affect multiple stages of wound healing. This effect, however, is paradoxical for scarless wound healing. On the one hand, Lep exerts pro‐inflammatory and profibrotic effects; on the other hand, Lep can regulate hair follicle growth. 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| subjects | Animals Appendages Cicatrix, Hypertrophic - pathology Humans Inflammation leptin Leptin - metabolism leptin receptor Leptin receptors Receptors, Leptin - metabolism scar Scars skin Skin - metabolism Wound Healing |
| title | LEP and LEPR are possibly a double‐edged sword for wound healing |
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