Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism
Objective Patients with chronic hypoparathyroidism (cHypoPT) are prone to intracranial‐calcification, cataract and nephrocalcinosis. In this study, we systematically investigated the possibility of increased coronary artery calcification (CAC) and coronary artery disease (CAD) in them. Design Cross‐...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2023-04, Vol.98 (4), p.505-515 |
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| creator | Saha, Soma Narang, Rajiv Goswami, Ravinder Pandey, Niraj Nirmal Sharma, Vibhav Kalaivani, Mani Sen, Sakshi Kandasamy, Devasenathipathy Chandran, Dinu S. Deepak, Kishore Kumar |
| description | Objective
Patients with chronic hypoparathyroidism (cHypoPT) are prone to intracranial‐calcification, cataract and nephrocalcinosis. In this study, we systematically investigated the possibility of increased coronary artery calcification (CAC) and coronary artery disease (CAD) in them.
Design
Cross‐sectional.
Patients and Measurements
Ninety‐four nonsurgical cHypoPT (M:F = 50:44; age = 45 ± 15 years) with 18.6 ± 9.3 years of illness were assessed. Those with dyspnoea, angina, syncope, abnormal electrocardiogram, echocardiography or significant CAC underwent coronary angiography or myocardial‐perfusion‐stress imaging. Their lipid parameters and high‐sensitivity C‐reactive protein (hsCRP) were compared with age‐matched healthy controls (Group A, n = 101). The prevalence of CAC in cHypoPT was compared with that of subjects referred from cardiology‐clinics (Group B, n = 148, age = 52 ± 11 years).
Results
One of 94 cHypoPT had known CAD. On screening, 17 cHypoPT required evaluation for CAD. Two of 17 had severe coronary stenosis, and 12 showed subclinical CAD. CAC and aortic‐valve calcification occurred in 21.5% and 11.8%. Clinical and subclinical CAD, CAC and aortic‐valve calcification in cHypoPT ≥50 years of age was 8.1%, 27.0%, 52.8% and 27.8%, respectively. Frequency of age‐adjusted CAC was comparable between cHypoPT and control Group B (30.2% vs. 30.7%, p = .93). Elevated hsCRP was higher in cHypoPT than in controls A (52% vs. 32%, p |
| doi_str_mv | 10.1111/cen.14872 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2758354761</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2758354761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-54a5ead42310821fc5b8663304b3a79e62e840a4a6ef7ca2c24ec9adb1cb6efe3</originalsourceid><addsrcrecordid>eNp1kU1rGzEQhkVpaFy3h_6BIOglPayt710fg3GbQkguyXmZ1Y5rOWtpI-3G-N9Hqd0cCtFlQPPwzDAvId84m_H85hb9jKuqFB_IhEujCyGM_kgmTDJWMGPUOfmc0pYxpitWfiLnmTGlWugJeVyGGDzEA4U4YC6tSwgJKfiWuiHRZ0h27CBSSClYBwMm6jztYXDoc3_vhg21myxxlvrg0xj_OAsd3Rz60EOEYXOIwWXt7gs5W0OX8OupTsnDz9X98rq4ufv1e3l1U1ippSi0Ao3QKiE5qwRfW91UxkjJVCOhXKARWCkGCgyuSwvCCoV2AW3DbZO_UE7J5dHbx_A0YhrqnUsWuw48hjHVotSV1Ko0PKPf_0O3YYw-b5epSvOFrPLkKflxpGwMKUVc1310u3y0mrP6NYE6J1D_TSCzFyfj2OywfSP_nTwD8yOwdx0e3jfVy9XtUfkCbDmR5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2785193863</pqid></control><display><type>article</type><title>Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Saha, Soma ; Narang, Rajiv ; Goswami, Ravinder ; Pandey, Niraj Nirmal ; Sharma, Vibhav ; Kalaivani, Mani ; Sen, Sakshi ; Kandasamy, Devasenathipathy ; Chandran, Dinu S. ; Deepak, Kishore Kumar</creator><creatorcontrib>Saha, Soma ; Narang, Rajiv ; Goswami, Ravinder ; Pandey, Niraj Nirmal ; Sharma, Vibhav ; Kalaivani, Mani ; Sen, Sakshi ; Kandasamy, Devasenathipathy ; Chandran, Dinu S. ; Deepak, Kishore Kumar</creatorcontrib><description>Objective
Patients with chronic hypoparathyroidism (cHypoPT) are prone to intracranial‐calcification, cataract and nephrocalcinosis. In this study, we systematically investigated the possibility of increased coronary artery calcification (CAC) and coronary artery disease (CAD) in them.
Design
Cross‐sectional.
Patients and Measurements
Ninety‐four nonsurgical cHypoPT (M:F = 50:44; age = 45 ± 15 years) with 18.6 ± 9.3 years of illness were assessed. Those with dyspnoea, angina, syncope, abnormal electrocardiogram, echocardiography or significant CAC underwent coronary angiography or myocardial‐perfusion‐stress imaging. Their lipid parameters and high‐sensitivity C‐reactive protein (hsCRP) were compared with age‐matched healthy controls (Group A, n = 101). The prevalence of CAC in cHypoPT was compared with that of subjects referred from cardiology‐clinics (Group B, n = 148, age = 52 ± 11 years).
Results
One of 94 cHypoPT had known CAD. On screening, 17 cHypoPT required evaluation for CAD. Two of 17 had severe coronary stenosis, and 12 showed subclinical CAD. CAC and aortic‐valve calcification occurred in 21.5% and 11.8%. Clinical and subclinical CAD, CAC and aortic‐valve calcification in cHypoPT ≥50 years of age was 8.1%, 27.0%, 52.8% and 27.8%, respectively. Frequency of age‐adjusted CAC was comparable between cHypoPT and control Group B (30.2% vs. 30.7%, p = .93). Elevated hsCRP was higher in cHypoPT than in controls A (52% vs. 32%, p < .01). Factors associated with CAD in cHypoPT were CAC and hypertension. However, CAD and CAC showed no association with long‐term calcemic or phosphatemic control and intracranial‐calcification in cHypoPT.
Conclusions
Clinical and subclinical CAD was observed in 3.2% and 12.8% of cHypoPT patients. The increased prevalence of CAD, CAC and aortic‐valve calcification in cHypoPT above 50 years of age suggested their careful cardiac evaluation during follow‐up.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.14872</identifier><identifier>PMID: 36567495</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age ; Angina ; Angiography ; C-Reactive Protein ; Calcification ; Calcification (ectopic) ; Calcinosis ; Cardiovascular disease ; Coronary Angiography ; coronary artery calcification ; Coronary artery disease ; Coronary Artery Disease - epidemiology ; Coronary vessels ; Cross-Sectional Studies ; Dyspnea ; Echocardiography ; EKG ; Heart diseases ; Humans ; Hypoparathyroidism ; Kidney diseases ; Middle Aged ; Respiration ; Risk Factors ; Stenosis ; Syncope ; Tomography, X-Ray Computed ; Vascular Calcification - complications ; Vein & artery diseases</subject><ispartof>Clinical endocrinology (Oxford), 2023-04, Vol.98 (4), p.505-515</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2023 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-54a5ead42310821fc5b8663304b3a79e62e840a4a6ef7ca2c24ec9adb1cb6efe3</citedby><cites>FETCH-LOGICAL-c3532-54a5ead42310821fc5b8663304b3a79e62e840a4a6ef7ca2c24ec9adb1cb6efe3</cites><orcidid>0000-0002-3097-5074 ; 0000-0003-1403-1433</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.14872$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.14872$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36567495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saha, Soma</creatorcontrib><creatorcontrib>Narang, Rajiv</creatorcontrib><creatorcontrib>Goswami, Ravinder</creatorcontrib><creatorcontrib>Pandey, Niraj Nirmal</creatorcontrib><creatorcontrib>Sharma, Vibhav</creatorcontrib><creatorcontrib>Kalaivani, Mani</creatorcontrib><creatorcontrib>Sen, Sakshi</creatorcontrib><creatorcontrib>Kandasamy, Devasenathipathy</creatorcontrib><creatorcontrib>Chandran, Dinu S.</creatorcontrib><creatorcontrib>Deepak, Kishore Kumar</creatorcontrib><title>Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Objective
Patients with chronic hypoparathyroidism (cHypoPT) are prone to intracranial‐calcification, cataract and nephrocalcinosis. In this study, we systematically investigated the possibility of increased coronary artery calcification (CAC) and coronary artery disease (CAD) in them.
Design
Cross‐sectional.
Patients and Measurements
Ninety‐four nonsurgical cHypoPT (M:F = 50:44; age = 45 ± 15 years) with 18.6 ± 9.3 years of illness were assessed. Those with dyspnoea, angina, syncope, abnormal electrocardiogram, echocardiography or significant CAC underwent coronary angiography or myocardial‐perfusion‐stress imaging. Their lipid parameters and high‐sensitivity C‐reactive protein (hsCRP) were compared with age‐matched healthy controls (Group A, n = 101). The prevalence of CAC in cHypoPT was compared with that of subjects referred from cardiology‐clinics (Group B, n = 148, age = 52 ± 11 years).
Results
One of 94 cHypoPT had known CAD. On screening, 17 cHypoPT required evaluation for CAD. Two of 17 had severe coronary stenosis, and 12 showed subclinical CAD. CAC and aortic‐valve calcification occurred in 21.5% and 11.8%. Clinical and subclinical CAD, CAC and aortic‐valve calcification in cHypoPT ≥50 years of age was 8.1%, 27.0%, 52.8% and 27.8%, respectively. Frequency of age‐adjusted CAC was comparable between cHypoPT and control Group B (30.2% vs. 30.7%, p = .93). Elevated hsCRP was higher in cHypoPT than in controls A (52% vs. 32%, p < .01). Factors associated with CAD in cHypoPT were CAC and hypertension. However, CAD and CAC showed no association with long‐term calcemic or phosphatemic control and intracranial‐calcification in cHypoPT.
Conclusions
Clinical and subclinical CAD was observed in 3.2% and 12.8% of cHypoPT patients. The increased prevalence of CAD, CAC and aortic‐valve calcification in cHypoPT above 50 years of age suggested their careful cardiac evaluation during follow‐up.</description><subject>Adult</subject><subject>Age</subject><subject>Angina</subject><subject>Angiography</subject><subject>C-Reactive Protein</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Calcinosis</subject><subject>Cardiovascular disease</subject><subject>Coronary Angiography</subject><subject>coronary artery calcification</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Dyspnea</subject><subject>Echocardiography</subject><subject>EKG</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypoparathyroidism</subject><subject>Kidney diseases</subject><subject>Middle Aged</subject><subject>Respiration</subject><subject>Risk Factors</subject><subject>Stenosis</subject><subject>Syncope</subject><subject>Tomography, X-Ray Computed</subject><subject>Vascular Calcification - complications</subject><subject>Vein & artery diseases</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1rGzEQhkVpaFy3h_6BIOglPayt710fg3GbQkguyXmZ1Y5rOWtpI-3G-N9Hqd0cCtFlQPPwzDAvId84m_H85hb9jKuqFB_IhEujCyGM_kgmTDJWMGPUOfmc0pYxpitWfiLnmTGlWugJeVyGGDzEA4U4YC6tSwgJKfiWuiHRZ0h27CBSSClYBwMm6jztYXDoc3_vhg21myxxlvrg0xj_OAsd3Rz60EOEYXOIwWXt7gs5W0OX8OupTsnDz9X98rq4ufv1e3l1U1ippSi0Ao3QKiE5qwRfW91UxkjJVCOhXKARWCkGCgyuSwvCCoV2AW3DbZO_UE7J5dHbx_A0YhrqnUsWuw48hjHVotSV1Ko0PKPf_0O3YYw-b5epSvOFrPLkKflxpGwMKUVc1310u3y0mrP6NYE6J1D_TSCzFyfj2OywfSP_nTwD8yOwdx0e3jfVy9XtUfkCbDmR5Q</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Saha, Soma</creator><creator>Narang, Rajiv</creator><creator>Goswami, Ravinder</creator><creator>Pandey, Niraj Nirmal</creator><creator>Sharma, Vibhav</creator><creator>Kalaivani, Mani</creator><creator>Sen, Sakshi</creator><creator>Kandasamy, Devasenathipathy</creator><creator>Chandran, Dinu S.</creator><creator>Deepak, Kishore Kumar</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3097-5074</orcidid><orcidid>https://orcid.org/0000-0003-1403-1433</orcidid></search><sort><creationdate>202304</creationdate><title>Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism</title><author>Saha, Soma ; Narang, Rajiv ; Goswami, Ravinder ; Pandey, Niraj Nirmal ; Sharma, Vibhav ; Kalaivani, Mani ; Sen, Sakshi ; Kandasamy, Devasenathipathy ; Chandran, Dinu S. ; Deepak, Kishore Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-54a5ead42310821fc5b8663304b3a79e62e840a4a6ef7ca2c24ec9adb1cb6efe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Age</topic><topic>Angina</topic><topic>Angiography</topic><topic>C-Reactive Protein</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Calcinosis</topic><topic>Cardiovascular disease</topic><topic>Coronary Angiography</topic><topic>coronary artery calcification</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary vessels</topic><topic>Cross-Sectional Studies</topic><topic>Dyspnea</topic><topic>Echocardiography</topic><topic>EKG</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hypoparathyroidism</topic><topic>Kidney diseases</topic><topic>Middle Aged</topic><topic>Respiration</topic><topic>Risk Factors</topic><topic>Stenosis</topic><topic>Syncope</topic><topic>Tomography, X-Ray Computed</topic><topic>Vascular Calcification - complications</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saha, Soma</creatorcontrib><creatorcontrib>Narang, Rajiv</creatorcontrib><creatorcontrib>Goswami, Ravinder</creatorcontrib><creatorcontrib>Pandey, Niraj Nirmal</creatorcontrib><creatorcontrib>Sharma, Vibhav</creatorcontrib><creatorcontrib>Kalaivani, Mani</creatorcontrib><creatorcontrib>Sen, Sakshi</creatorcontrib><creatorcontrib>Kandasamy, Devasenathipathy</creatorcontrib><creatorcontrib>Chandran, Dinu S.</creatorcontrib><creatorcontrib>Deepak, Kishore Kumar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saha, Soma</au><au>Narang, Rajiv</au><au>Goswami, Ravinder</au><au>Pandey, Niraj Nirmal</au><au>Sharma, Vibhav</au><au>Kalaivani, Mani</au><au>Sen, Sakshi</au><au>Kandasamy, Devasenathipathy</au><au>Chandran, Dinu S.</au><au>Deepak, Kishore Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2023-04</date><risdate>2023</risdate><volume>98</volume><issue>4</issue><spage>505</spage><epage>515</epage><pages>505-515</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Objective
Patients with chronic hypoparathyroidism (cHypoPT) are prone to intracranial‐calcification, cataract and nephrocalcinosis. In this study, we systematically investigated the possibility of increased coronary artery calcification (CAC) and coronary artery disease (CAD) in them.
Design
Cross‐sectional.
Patients and Measurements
Ninety‐four nonsurgical cHypoPT (M:F = 50:44; age = 45 ± 15 years) with 18.6 ± 9.3 years of illness were assessed. Those with dyspnoea, angina, syncope, abnormal electrocardiogram, echocardiography or significant CAC underwent coronary angiography or myocardial‐perfusion‐stress imaging. Their lipid parameters and high‐sensitivity C‐reactive protein (hsCRP) were compared with age‐matched healthy controls (Group A, n = 101). The prevalence of CAC in cHypoPT was compared with that of subjects referred from cardiology‐clinics (Group B, n = 148, age = 52 ± 11 years).
Results
One of 94 cHypoPT had known CAD. On screening, 17 cHypoPT required evaluation for CAD. Two of 17 had severe coronary stenosis, and 12 showed subclinical CAD. CAC and aortic‐valve calcification occurred in 21.5% and 11.8%. Clinical and subclinical CAD, CAC and aortic‐valve calcification in cHypoPT ≥50 years of age was 8.1%, 27.0%, 52.8% and 27.8%, respectively. Frequency of age‐adjusted CAC was comparable between cHypoPT and control Group B (30.2% vs. 30.7%, p = .93). Elevated hsCRP was higher in cHypoPT than in controls A (52% vs. 32%, p < .01). Factors associated with CAD in cHypoPT were CAC and hypertension. However, CAD and CAC showed no association with long‐term calcemic or phosphatemic control and intracranial‐calcification in cHypoPT.
Conclusions
Clinical and subclinical CAD was observed in 3.2% and 12.8% of cHypoPT patients. The increased prevalence of CAD, CAC and aortic‐valve calcification in cHypoPT above 50 years of age suggested their careful cardiac evaluation during follow‐up.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36567495</pmid><doi>10.1111/cen.14872</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3097-5074</orcidid><orcidid>https://orcid.org/0000-0003-1403-1433</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Age Angina Angiography C-Reactive Protein Calcification Calcification (ectopic) Calcinosis Cardiovascular disease Coronary Angiography coronary artery calcification Coronary artery disease Coronary Artery Disease - epidemiology Coronary vessels Cross-Sectional Studies Dyspnea Echocardiography EKG Heart diseases Humans Hypoparathyroidism Kidney diseases Middle Aged Respiration Risk Factors Stenosis Syncope Tomography, X-Ray Computed Vascular Calcification - complications Vein & artery diseases |
| title | Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism |
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