PROTACS: A technology with a gold rush-like atmosphere

Abnormally expressed or malfunctioning proteins may affect or even damage cells, leading to the onset of diseases. Proteolysis targeting chimera (PROTAC) technology has been proven to be a fresh therapeutic strategy, superior to conventional small molecule inhibitors for the treatment of diseases ca...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-02, Vol.247, p.115037-115037, Article 115037
Hauptverfasser:	Wang, Yu-Wei, Lan, Li, Wang, Min, Zhang, Jin-Yang, Gao, Yu-Hui, Shi, Lei, Sun, Li-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Atmosphere E3 ligases Gold PROTACs Proteasome Endopeptidase Complex - metabolism Protein degradation Proteins - metabolism Proteolysis Proteolysis Targeting Chimera Technology Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
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