p62/SQSTM1 indirectly mediates remote multipotent mesenchymal cells and rescues bone loss and bone marrow integrity in ovariectomized rats

Intramuscular administration of p62/SQSTM1 (sequestosome1)‐encoding plasmid demonstrated an anticancer effect in rodent models and dogs as well as a high safety profile and the first evidence of clinical benefits in humans. Also, an anti‐inflammatory effect of the plasmid was reported in several rod...

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Veröffentlicht in:	Journal of cellular physiology 2023-02, Vol.238 (2), p.407-419
Hauptverfasser:	Agas, Dimitrios, Marchegiani, Andrea, Laus, Fulvio, Gabai, Vladimir, Sufianov, Albert A., Shneider, Alexander, Sabbieti, Maria Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis Animal models Animals Anticancer properties Bone Diseases, Metabolic - pathology Bone loss Bone Marrow Bone Marrow Cells bone physiology Cell culture Cell Differentiation Cells, Cultured DNA plasmid Female Homeostasis Inflammation Mesenchymal Stem Cells Mesenchyme Mice Modulation multipotent mesenchymal cells Multipotent Stem Cells Oophorectomy Osteogenesis - physiology Osteoporosis Ovariectomy p62 Rats Rodents Sequestosome-1 Protein
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