Anxiety and depression in patients with narcolepsy
Summary We analysed the co‐existence of psychopathology in patients with narcolepsy at our centre. We performed an observational retrospective descriptive analysis of patients with a diagnosis of narcolepsy, with and without psychopathology, who attended our sleep disorders unit from October 2012 to...
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| Veröffentlicht in: | Journal of sleep research 2023-08, Vol.32 (4), p.e13812-n/a |
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| creator | Abenza‐Abildua, María José Suárez‐Gisbert, Eugenio Lores‐Gutiérrez, Vanesa Algarra‐Lucas, Carmen Gómez‐Aceña, Ángeles Navacerrada‐Barrero, Francisco José González‐Martín, Laura Pérez‐Villena, Ana Pérez‐López, Carlos |
| description | Summary
We analysed the co‐existence of psychopathology in patients with narcolepsy at our centre. We performed an observational retrospective descriptive analysis of patients with a diagnosis of narcolepsy, with and without psychopathology, who attended our sleep disorders unit from October 2012 to October 2021. A total of 51patients with narcolepsy (mean [SD] age 41.10 [14.71] years; 23 [45.1%] males and 28 [54.90%] females) were included. In all, 27 patients (52.94%) and 24 patients (47.06%) had narcolepsy with and without cataplexy, respectively. Of the total, 18 (33.33%) had a mood disorder: 18 with anxiety disorder (33.33%). Of these patients 14 (27.45%) had major depression, two (4%) had attempted suicide, one (2%) had manic outbreak, and one (2%) had substance abuse. Of the 18 patients with anxiety and depression, 10 (55.55%) and eight (44.44%) had narcolepsy with and without cataplexy, respectively. In the comparative analysis, a statistically significant relationship was found between younger age and the presence of anxiety. The prevalence of anxiety and depression in patients with narcolepsy was triple that of the general population, especially in younger patients. Psychopathology precedes the diagnosis of narcolepsy in most patients, not being reactive to diagnosis. This high prevalence suggests a possible biological relationship between both disorders, which should be assessed with larger studies. |
| doi_str_mv | 10.1111/jsr.13812 |
| format | Article |
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We analysed the co‐existence of psychopathology in patients with narcolepsy at our centre. We performed an observational retrospective descriptive analysis of patients with a diagnosis of narcolepsy, with and without psychopathology, who attended our sleep disorders unit from October 2012 to October 2021. A total of 51patients with narcolepsy (mean [SD] age 41.10 [14.71] years; 23 [45.1%] males and 28 [54.90%] females) were included. In all, 27 patients (52.94%) and 24 patients (47.06%) had narcolepsy with and without cataplexy, respectively. Of the total, 18 (33.33%) had a mood disorder: 18 with anxiety disorder (33.33%). Of these patients 14 (27.45%) had major depression, two (4%) had attempted suicide, one (2%) had manic outbreak, and one (2%) had substance abuse. Of the 18 patients with anxiety and depression, 10 (55.55%) and eight (44.44%) had narcolepsy with and without cataplexy, respectively. In the comparative analysis, a statistically significant relationship was found between younger age and the presence of anxiety. The prevalence of anxiety and depression in patients with narcolepsy was triple that of the general population, especially in younger patients. Psychopathology precedes the diagnosis of narcolepsy in most patients, not being reactive to diagnosis. This high prevalence suggests a possible biological relationship between both disorders, which should be assessed with larger studies.</description><identifier>ISSN: 0962-1105</identifier><identifier>EISSN: 1365-2869</identifier><identifier>DOI: 10.1111/jsr.13812</identifier><identifier>PMID: 36564940</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; anxiety ; Anxiety - complications ; Anxiety - epidemiology ; Anxiety Disorders - complications ; Anxiety Disorders - diagnosis ; Anxiety Disorders - epidemiology ; Cataplexy - complications ; Cataplexy - diagnosis ; Cataplexy - epidemiology ; depression ; Depression - complications ; Depression - epidemiology ; Female ; Humans ; Male ; mood disorders ; narcolepsy ; Narcolepsy - complications ; Narcolepsy - diagnosis ; Narcolepsy - epidemiology ; narcolepsy type 1 ; narcolepsy type 2 ; narcolepsy with cataplexy ; Retrospective Studies</subject><ispartof>Journal of sleep research, 2023-08, Vol.32 (4), p.e13812-n/a</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.</rights><rights>2022 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3602-7cf9ab252fd79b97625168edc9722eb854c0a2d2a342a81df2657b8342e25d2e3</citedby><cites>FETCH-LOGICAL-c3602-7cf9ab252fd79b97625168edc9722eb854c0a2d2a342a81df2657b8342e25d2e3</cites><orcidid>0000-0002-8741-1632</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjsr.13812$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjsr.13812$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36564940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abenza‐Abildua, María José</creatorcontrib><creatorcontrib>Suárez‐Gisbert, Eugenio</creatorcontrib><creatorcontrib>Lores‐Gutiérrez, Vanesa</creatorcontrib><creatorcontrib>Algarra‐Lucas, Carmen</creatorcontrib><creatorcontrib>Gómez‐Aceña, Ángeles</creatorcontrib><creatorcontrib>Navacerrada‐Barrero, Francisco José</creatorcontrib><creatorcontrib>González‐Martín, Laura</creatorcontrib><creatorcontrib>Pérez‐Villena, Ana</creatorcontrib><creatorcontrib>Pérez‐López, Carlos</creatorcontrib><title>Anxiety and depression in patients with narcolepsy</title><title>Journal of sleep research</title><addtitle>J Sleep Res</addtitle><description>Summary
We analysed the co‐existence of psychopathology in patients with narcolepsy at our centre. We performed an observational retrospective descriptive analysis of patients with a diagnosis of narcolepsy, with and without psychopathology, who attended our sleep disorders unit from October 2012 to October 2021. A total of 51patients with narcolepsy (mean [SD] age 41.10 [14.71] years; 23 [45.1%] males and 28 [54.90%] females) were included. In all, 27 patients (52.94%) and 24 patients (47.06%) had narcolepsy with and without cataplexy, respectively. Of the total, 18 (33.33%) had a mood disorder: 18 with anxiety disorder (33.33%). Of these patients 14 (27.45%) had major depression, two (4%) had attempted suicide, one (2%) had manic outbreak, and one (2%) had substance abuse. Of the 18 patients with anxiety and depression, 10 (55.55%) and eight (44.44%) had narcolepsy with and without cataplexy, respectively. In the comparative analysis, a statistically significant relationship was found between younger age and the presence of anxiety. The prevalence of anxiety and depression in patients with narcolepsy was triple that of the general population, especially in younger patients. Psychopathology precedes the diagnosis of narcolepsy in most patients, not being reactive to diagnosis. This high prevalence suggests a possible biological relationship between both disorders, which should be assessed with larger studies.</description><subject>Adult</subject><subject>anxiety</subject><subject>Anxiety - complications</subject><subject>Anxiety - epidemiology</subject><subject>Anxiety Disorders - complications</subject><subject>Anxiety Disorders - diagnosis</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Cataplexy - complications</subject><subject>Cataplexy - diagnosis</subject><subject>Cataplexy - epidemiology</subject><subject>depression</subject><subject>Depression - complications</subject><subject>Depression - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>mood disorders</subject><subject>narcolepsy</subject><subject>Narcolepsy - complications</subject><subject>Narcolepsy - diagnosis</subject><subject>Narcolepsy - epidemiology</subject><subject>narcolepsy type 1</subject><subject>narcolepsy type 2</subject><subject>narcolepsy with cataplexy</subject><subject>Retrospective Studies</subject><issn>0962-1105</issn><issn>1365-2869</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EoqUw8AdQRhjS2jexHY9VxVOVkHjMlhPfCFdpEuxUJf-eQICNu3y60tEZDiHnjM7ZcItN8HOWZAwOyJQlgseQCXVIplQJiBmjfEJOQthQyiRP1DGZDIxIVUqnBJb1h8Ouj0xtI4utxxBcU0eujlrTOay7EO1d9xbVxhdNhW3oT8lRaaqAZz87I6831y-ru3j9eHu_Wq7jIhEUYlmUyuTAobRS5UoK4ExkaAslATDPeFpQAxZMkoLJmC1BcJlnw4fALWAyI5ejt_XN-w5Dp7cuFFhVpsZmFzRInjHGmUoH9GpEC9-E4LHUrXdb43vNqP5KpIdE-jvRwF78aHf5Fu0f-dtkABYjsHcV9v-b9MPz06j8BIG1byM</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Abenza‐Abildua, María José</creator><creator>Suárez‐Gisbert, Eugenio</creator><creator>Lores‐Gutiérrez, Vanesa</creator><creator>Algarra‐Lucas, Carmen</creator><creator>Gómez‐Aceña, Ángeles</creator><creator>Navacerrada‐Barrero, Francisco José</creator><creator>González‐Martín, Laura</creator><creator>Pérez‐Villena, Ana</creator><creator>Pérez‐López, Carlos</creator><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8741-1632</orcidid></search><sort><creationdate>202308</creationdate><title>Anxiety and depression in patients with narcolepsy</title><author>Abenza‐Abildua, María José ; Suárez‐Gisbert, Eugenio ; Lores‐Gutiérrez, Vanesa ; Algarra‐Lucas, Carmen ; Gómez‐Aceña, Ángeles ; Navacerrada‐Barrero, Francisco José ; González‐Martín, Laura ; Pérez‐Villena, Ana ; Pérez‐López, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3602-7cf9ab252fd79b97625168edc9722eb854c0a2d2a342a81df2657b8342e25d2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>anxiety</topic><topic>Anxiety - complications</topic><topic>Anxiety - epidemiology</topic><topic>Anxiety Disorders - complications</topic><topic>Anxiety Disorders - diagnosis</topic><topic>Anxiety Disorders - epidemiology</topic><topic>Cataplexy - complications</topic><topic>Cataplexy - diagnosis</topic><topic>Cataplexy - epidemiology</topic><topic>depression</topic><topic>Depression - complications</topic><topic>Depression - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>mood disorders</topic><topic>narcolepsy</topic><topic>Narcolepsy - complications</topic><topic>Narcolepsy - diagnosis</topic><topic>Narcolepsy - epidemiology</topic><topic>narcolepsy type 1</topic><topic>narcolepsy type 2</topic><topic>narcolepsy with cataplexy</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abenza‐Abildua, María José</creatorcontrib><creatorcontrib>Suárez‐Gisbert, Eugenio</creatorcontrib><creatorcontrib>Lores‐Gutiérrez, Vanesa</creatorcontrib><creatorcontrib>Algarra‐Lucas, Carmen</creatorcontrib><creatorcontrib>Gómez‐Aceña, Ángeles</creatorcontrib><creatorcontrib>Navacerrada‐Barrero, Francisco José</creatorcontrib><creatorcontrib>González‐Martín, Laura</creatorcontrib><creatorcontrib>Pérez‐Villena, Ana</creatorcontrib><creatorcontrib>Pérez‐López, Carlos</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of sleep research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abenza‐Abildua, María José</au><au>Suárez‐Gisbert, Eugenio</au><au>Lores‐Gutiérrez, Vanesa</au><au>Algarra‐Lucas, Carmen</au><au>Gómez‐Aceña, Ángeles</au><au>Navacerrada‐Barrero, Francisco José</au><au>González‐Martín, Laura</au><au>Pérez‐Villena, Ana</au><au>Pérez‐López, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anxiety and depression in patients with narcolepsy</atitle><jtitle>Journal of sleep research</jtitle><addtitle>J Sleep Res</addtitle><date>2023-08</date><risdate>2023</risdate><volume>32</volume><issue>4</issue><spage>e13812</spage><epage>n/a</epage><pages>e13812-n/a</pages><issn>0962-1105</issn><eissn>1365-2869</eissn><abstract>Summary
We analysed the co‐existence of psychopathology in patients with narcolepsy at our centre. We performed an observational retrospective descriptive analysis of patients with a diagnosis of narcolepsy, with and without psychopathology, who attended our sleep disorders unit from October 2012 to October 2021. A total of 51patients with narcolepsy (mean [SD] age 41.10 [14.71] years; 23 [45.1%] males and 28 [54.90%] females) were included. In all, 27 patients (52.94%) and 24 patients (47.06%) had narcolepsy with and without cataplexy, respectively. Of the total, 18 (33.33%) had a mood disorder: 18 with anxiety disorder (33.33%). Of these patients 14 (27.45%) had major depression, two (4%) had attempted suicide, one (2%) had manic outbreak, and one (2%) had substance abuse. Of the 18 patients with anxiety and depression, 10 (55.55%) and eight (44.44%) had narcolepsy with and without cataplexy, respectively. In the comparative analysis, a statistically significant relationship was found between younger age and the presence of anxiety. The prevalence of anxiety and depression in patients with narcolepsy was triple that of the general population, especially in younger patients. Psychopathology precedes the diagnosis of narcolepsy in most patients, not being reactive to diagnosis. This high prevalence suggests a possible biological relationship between both disorders, which should be assessed with larger studies.</abstract><cop>England</cop><pmid>36564940</pmid><doi>10.1111/jsr.13812</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8741-1632</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult anxiety Anxiety - complications Anxiety - epidemiology Anxiety Disorders - complications Anxiety Disorders - diagnosis Anxiety Disorders - epidemiology Cataplexy - complications Cataplexy - diagnosis Cataplexy - epidemiology depression Depression - complications Depression - epidemiology Female Humans Male mood disorders narcolepsy Narcolepsy - complications Narcolepsy - diagnosis Narcolepsy - epidemiology narcolepsy type 1 narcolepsy type 2 narcolepsy with cataplexy Retrospective Studies |
| title | Anxiety and depression in patients with narcolepsy |
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