Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy
Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial and anti‐fungal, has shown many ph...
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| Veröffentlicht in: | Phytotherapy research 2023-03, Vol.37 (3), p.1115-1135 |
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| description | Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial and anti‐fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS‐CoV‐2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti‐proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID‐19). |
| doi_str_mv | 10.1002/ptr.7707 |
| format | Article |
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CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial and anti‐fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS‐CoV‐2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti‐proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID‐19).</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7707</identifier><identifier>PMID: 36562210</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Alternative medicine ; Anti-Inflammatory Agents - pharmacology ; Binding ; Caffeic acid ; caffeic acid phenethyl ester ; Caffeic Acids - chemistry ; Cancer ; Cell proliferation ; complementary medicine ; coronavirus disease 2019 ; Coronaviruses ; COVID-19 ; Enzymes ; Flavonoids ; Free Radicals ; Humans ; Inflammation ; irradiation ; Molecular docking ; Molecular Docking Simulation ; molecular docking study ; Natural products ; Pharmacology ; Phenylethyl Alcohol - chemistry ; Phenylethyl Alcohol - metabolism ; Phenylethyl Alcohol - pharmacology ; Radiation protection ; Radiation therapy ; Radiosensitization ; radiotherapy ; Replication ; SARS-CoV-2 ; Security ; Severe acute respiratory syndrome coronavirus 2 ; therapeutic benefits ; Viral diseases</subject><ispartof>Phytotherapy research, 2023-03, Vol.37 (3), p.1115-1135</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2023 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3837-5fa6391ca8d8def25b5987aff38cc0d3c72a783c7eaa87d740a42448b7a6533d3</citedby><cites>FETCH-LOGICAL-c3837-5fa6391ca8d8def25b5987aff38cc0d3c72a783c7eaa87d740a42448b7a6533d3</cites><orcidid>0000-0002-8006-8261 ; 0000-0001-7419-5988 ; 0000-0003-1251-3148 ; 0000-0001-5608-554X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7707$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7707$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36562210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taysi, Seyithan</creatorcontrib><creatorcontrib>Algburi, Firas Shawqi</creatorcontrib><creatorcontrib>Taysi, Muhammed Enes</creatorcontrib><creatorcontrib>Caglayan, Cuneyt</creatorcontrib><title>Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial and anti‐fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS‐CoV‐2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti‐proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID‐19).</description><subject>Alternative medicine</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Binding</subject><subject>Caffeic acid</subject><subject>caffeic acid phenethyl ester</subject><subject>Caffeic Acids - chemistry</subject><subject>Cancer</subject><subject>Cell proliferation</subject><subject>complementary medicine</subject><subject>coronavirus disease 2019</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Enzymes</subject><subject>Flavonoids</subject><subject>Free Radicals</subject><subject>Humans</subject><subject>Inflammation</subject><subject>irradiation</subject><subject>Molecular docking</subject><subject>Molecular Docking Simulation</subject><subject>molecular docking study</subject><subject>Natural products</subject><subject>Pharmacology</subject><subject>Phenylethyl Alcohol - chemistry</subject><subject>Phenylethyl Alcohol - metabolism</subject><subject>Phenylethyl Alcohol - pharmacology</subject><subject>Radiation protection</subject><subject>Radiation therapy</subject><subject>Radiosensitization</subject><subject>radiotherapy</subject><subject>Replication</subject><subject>SARS-CoV-2</subject><subject>Security</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>therapeutic benefits</subject><subject>Viral diseases</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9O3DAQhy1UBAtF4gkqS730QMCOk9jpDW35s9JKoIpWvUWz9oQ1SuLUzna1N54A8Yw8CV4WqFSppznM9_s0ox8hh5wdc8bSk37wx1IyuUVGnJVlwnMpPpARK3OeZFz92iV7IdwxxsqUZTtkVxR5kaacjcjDGOoaraagraH9HDsc5quGYhjQf6Wn1OMfi0vqOmqHEAHwLWjXuFuroaG27Z0foNN4RKEzLwyE4LSFwcbM0g5zWntE6sGsE-GIjq9-Tr493T_ycpNZb9wwRw_96iPZriOEB69zn_w4P7sZXybTq4vJ-HSaaKGETPIaClFyDcoog3Waz_JSyfiJUFozI7RMQao4EEBJIzMGWZplaiahyIUwYp982Xh7734v4rNVa4PGpoEO3SJUqcwV50wKHtHP_6B3buG7eF2kFC-kKGTxV6i9C8FjXfXetuBXFWfVuqMqdlStO4rop1fhYtaieQffSolAsgGWtsHVf0XV9c33F-EzsxGcSA</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Taysi, Seyithan</creator><creator>Algburi, Firas Shawqi</creator><creator>Taysi, Muhammed Enes</creator><creator>Caglayan, Cuneyt</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8006-8261</orcidid><orcidid>https://orcid.org/0000-0001-7419-5988</orcidid><orcidid>https://orcid.org/0000-0003-1251-3148</orcidid><orcidid>https://orcid.org/0000-0001-5608-554X</orcidid></search><sort><creationdate>202303</creationdate><title>Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy</title><author>Taysi, Seyithan ; Algburi, Firas Shawqi ; Taysi, Muhammed Enes ; Caglayan, Cuneyt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3837-5fa6391ca8d8def25b5987aff38cc0d3c72a783c7eaa87d740a42448b7a6533d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alternative medicine</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Binding</topic><topic>Caffeic acid</topic><topic>caffeic acid phenethyl ester</topic><topic>Caffeic Acids - chemistry</topic><topic>Cancer</topic><topic>Cell proliferation</topic><topic>complementary medicine</topic><topic>coronavirus disease 2019</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Enzymes</topic><topic>Flavonoids</topic><topic>Free Radicals</topic><topic>Humans</topic><topic>Inflammation</topic><topic>irradiation</topic><topic>Molecular docking</topic><topic>Molecular Docking Simulation</topic><topic>molecular docking study</topic><topic>Natural products</topic><topic>Pharmacology</topic><topic>Phenylethyl Alcohol - chemistry</topic><topic>Phenylethyl Alcohol - metabolism</topic><topic>Phenylethyl Alcohol - pharmacology</topic><topic>Radiation protection</topic><topic>Radiation therapy</topic><topic>Radiosensitization</topic><topic>radiotherapy</topic><topic>Replication</topic><topic>SARS-CoV-2</topic><topic>Security</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>therapeutic benefits</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taysi, Seyithan</creatorcontrib><creatorcontrib>Algburi, Firas Shawqi</creatorcontrib><creatorcontrib>Taysi, Muhammed Enes</creatorcontrib><creatorcontrib>Caglayan, Cuneyt</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taysi, Seyithan</au><au>Algburi, Firas Shawqi</au><au>Taysi, Muhammed Enes</au><au>Caglayan, Cuneyt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2023-03</date><risdate>2023</risdate><volume>37</volume><issue>3</issue><spage>1115</spage><epage>1135</epage><pages>1115-1135</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial and anti‐fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS‐CoV‐2. 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| ispartof | Phytotherapy research, 2023-03, Vol.37 (3), p.1115-1135 |
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| subjects | Alternative medicine Anti-Inflammatory Agents - pharmacology Binding Caffeic acid caffeic acid phenethyl ester Caffeic Acids - chemistry Cancer Cell proliferation complementary medicine coronavirus disease 2019 Coronaviruses COVID-19 Enzymes Flavonoids Free Radicals Humans Inflammation irradiation Molecular docking Molecular Docking Simulation molecular docking study Natural products Pharmacology Phenylethyl Alcohol - chemistry Phenylethyl Alcohol - metabolism Phenylethyl Alcohol - pharmacology Radiation protection Radiation therapy Radiosensitization radiotherapy Replication SARS-CoV-2 Security Severe acute respiratory syndrome coronavirus 2 therapeutic benefits Viral diseases |
| title | Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy |
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