Interaction of C-terminal p53 isoforms depends strongly upon DNA sequence and topology

The p53 protein is a key tumor suppressor and the most commonly mutated and down-regulated protein in human tumors. It functions mainly through interaction with DNA, and p53 acts as a transcription factor that recognizes the so-called p53 target sites on the promoters of various genes. P53 has been...

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Veröffentlicht in:	Biochimie 2023-05, Vol.208, p.93-99
Hauptverfasser:	Goswami, Pratik, Šislerová, Lucie, Dobrovolná, Michaela, Havlík, Jan, Šťastný, Jiří, Brázda, Václav
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Atomic force microscopy Base Sequence DNA - genetics DNA - metabolism G-quadruplex Humans p53 isoforms p53-DNA binding Protein Isoforms - genetics Protein Isoforms - metabolism Supercoiled DNA Tumor Suppressor Protein p53 - metabolism
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