Sociodemographic characteristics differ across routine adult vaccine cohorts: An All of Us descriptive study
The National Institutes of Health All of Us (AoU) Research Program is currently building a database of 1million+ adult subjects. With it, we describe the characteristics of those with documented vaccinations. To describe the sociodemographic, health status, and lifestyle factors associated with vacc...
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| Veröffentlicht in: | Journal of the American Pharmacists Association 2023-03, Vol.63 (2), p.582-591.e20 |
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| creator | Ng, Ding Quan Jia, Stanley Wisseh, Cheryl Cadiz, Christine Nguyen, Megan Lee, Joyce McBane, Sarah Nguyen, Lee Chan, Alexandre Hurley-Kim, Keri |
| description | The National Institutes of Health All of Us (AoU) Research Program is currently building a database of 1million+ adult subjects. With it, we describe the characteristics of those with documented vaccinations.
To describe the sociodemographic, health status, and lifestyle factors associated with vaccinations.
This is a retrospective study involving data from the AoU program (R2020Q4R2, N = 315,297). Five vaccine cohorts [influenza, hepatitis B (HBV), pneumococcal |
| doi_str_mv | 10.1016/j.japh.2022.11.005 |
| format | Article |
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To describe the sociodemographic, health status, and lifestyle factors associated with vaccinations.
This is a retrospective study involving data from the AoU program (R2020Q4R2, N = 315,297). Five vaccine cohorts [influenza, hepatitis B (HBV), pneumococcal <65 years old, pneumococcal ≥65 years old, and human papillomavirus (HPV)] were generated based on vaccination history. The influenza cohort comprised participants with documented influenza vaccinations in electronic health records (EHRs) from September 2017 to May 2018. Other vaccine cohorts comprised participants with ≥1 lifetime record(s) of vaccination documented in the EHR by December 2018. The vaccine cohorts were compared to the overall AoU cohort. Descriptive statistics were generated using EHR- and survey-based sociodemographic, health, and lifestyle information. The SAMBA (0.9.0) R package was utilized to adjust for EHR selection and outcome misclassification biases to infer sources of disparity for pneumococcal vaccinations in older adults.
Cohort counts were as follows: influenza (n = 15,346), HBV (n = 6323), pneumococcal <65 (n = 15,217), pneumococcal ≥65 (n = 15,100), and HPV (n = 2125). All vaccine cohorts had higher proportions of White and non-Hispanic/Latino participants compared to the overall AoU cohort. The largest differences were found in pneumococcal age ≥65, with 80.2% White participants compared to 52.9% in the overall study population. Multivariable analysis revealed that race/ethnic disparities in pneumococcal vaccination among older adults were explained by biological sex, income, health insurance, and education-related variables.
Racial, ethnic, education, and income characteristics differ across the vaccine cohorts among AoU participants. These findings inform future utilization of large health databases in vaccine epidemiology research and emphasize the need for more targeted interventions that address differences in vaccine uptake.</description><identifier>ISSN: 1544-3191</identifier><identifier>EISSN: 1544-3450</identifier><identifier>DOI: 10.1016/j.japh.2022.11.005</identifier><identifier>PMID: 36549934</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Humans ; Influenza Vaccines ; Influenza, Human - prevention & control ; Papillomavirus Infections ; Pneumococcal Vaccines ; Population Health ; Retrospective Studies ; Vaccination</subject><ispartof>Journal of the American Pharmacists Association, 2023-03, Vol.63 (2), p.582-591.e20</ispartof><rights>2022 American Pharmacists Association</rights><rights>Copyright © 2022 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-ff65536e98a2d0e0d1bdcbf09706879e95bc1fbdeed4d2906267b7083e508ca43</citedby><cites>FETCH-LOGICAL-c400t-ff65536e98a2d0e0d1bdcbf09706879e95bc1fbdeed4d2906267b7083e508ca43</cites><orcidid>0000-0002-3009-5966 ; 0000-0002-0754-7901 ; 0000-0001-9308-7384 ; 0000-0002-7988-3250 ; 0000-0002-0254-8059 ; 0000-0003-4391-4219</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36549934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Ding Quan</creatorcontrib><creatorcontrib>Jia, Stanley</creatorcontrib><creatorcontrib>Wisseh, Cheryl</creatorcontrib><creatorcontrib>Cadiz, Christine</creatorcontrib><creatorcontrib>Nguyen, Megan</creatorcontrib><creatorcontrib>Lee, Joyce</creatorcontrib><creatorcontrib>McBane, Sarah</creatorcontrib><creatorcontrib>Nguyen, Lee</creatorcontrib><creatorcontrib>Chan, Alexandre</creatorcontrib><creatorcontrib>Hurley-Kim, Keri</creatorcontrib><title>Sociodemographic characteristics differ across routine adult vaccine cohorts: An All of Us descriptive study</title><title>Journal of the American Pharmacists Association</title><addtitle>J Am Pharm Assoc (2003)</addtitle><description>The National Institutes of Health All of Us (AoU) Research Program is currently building a database of 1million+ adult subjects. With it, we describe the characteristics of those with documented vaccinations.
To describe the sociodemographic, health status, and lifestyle factors associated with vaccinations.
This is a retrospective study involving data from the AoU program (R2020Q4R2, N = 315,297). Five vaccine cohorts [influenza, hepatitis B (HBV), pneumococcal <65 years old, pneumococcal ≥65 years old, and human papillomavirus (HPV)] were generated based on vaccination history. The influenza cohort comprised participants with documented influenza vaccinations in electronic health records (EHRs) from September 2017 to May 2018. Other vaccine cohorts comprised participants with ≥1 lifetime record(s) of vaccination documented in the EHR by December 2018. The vaccine cohorts were compared to the overall AoU cohort. Descriptive statistics were generated using EHR- and survey-based sociodemographic, health, and lifestyle information. The SAMBA (0.9.0) R package was utilized to adjust for EHR selection and outcome misclassification biases to infer sources of disparity for pneumococcal vaccinations in older adults.
Cohort counts were as follows: influenza (n = 15,346), HBV (n = 6323), pneumococcal <65 (n = 15,217), pneumococcal ≥65 (n = 15,100), and HPV (n = 2125). All vaccine cohorts had higher proportions of White and non-Hispanic/Latino participants compared to the overall AoU cohort. The largest differences were found in pneumococcal age ≥65, with 80.2% White participants compared to 52.9% in the overall study population. Multivariable analysis revealed that race/ethnic disparities in pneumococcal vaccination among older adults were explained by biological sex, income, health insurance, and education-related variables.
Racial, ethnic, education, and income characteristics differ across the vaccine cohorts among AoU participants. 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Jia, Stanley ; Wisseh, Cheryl ; Cadiz, Christine ; Nguyen, Megan ; Lee, Joyce ; McBane, Sarah ; Nguyen, Lee ; Chan, Alexandre ; Hurley-Kim, Keri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-ff65536e98a2d0e0d1bdcbf09706879e95bc1fbdeed4d2906267b7083e508ca43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Humans</topic><topic>Influenza Vaccines</topic><topic>Influenza, Human - prevention & control</topic><topic>Papillomavirus Infections</topic><topic>Pneumococcal Vaccines</topic><topic>Population Health</topic><topic>Retrospective Studies</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Ding Quan</creatorcontrib><creatorcontrib>Jia, Stanley</creatorcontrib><creatorcontrib>Wisseh, Cheryl</creatorcontrib><creatorcontrib>Cadiz, Christine</creatorcontrib><creatorcontrib>Nguyen, Megan</creatorcontrib><creatorcontrib>Lee, Joyce</creatorcontrib><creatorcontrib>McBane, Sarah</creatorcontrib><creatorcontrib>Nguyen, Lee</creatorcontrib><creatorcontrib>Chan, Alexandre</creatorcontrib><creatorcontrib>Hurley-Kim, Keri</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Pharmacists Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Ding Quan</au><au>Jia, Stanley</au><au>Wisseh, Cheryl</au><au>Cadiz, Christine</au><au>Nguyen, Megan</au><au>Lee, Joyce</au><au>McBane, Sarah</au><au>Nguyen, Lee</au><au>Chan, Alexandre</au><au>Hurley-Kim, Keri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sociodemographic characteristics differ across routine adult vaccine cohorts: An All of Us descriptive study</atitle><jtitle>Journal of the American Pharmacists Association</jtitle><addtitle>J Am Pharm Assoc (2003)</addtitle><date>2023-03</date><risdate>2023</risdate><volume>63</volume><issue>2</issue><spage>582</spage><epage>591.e20</epage><pages>582-591.e20</pages><issn>1544-3191</issn><eissn>1544-3450</eissn><abstract>The National Institutes of Health All of Us (AoU) Research Program is currently building a database of 1million+ adult subjects. With it, we describe the characteristics of those with documented vaccinations.
To describe the sociodemographic, health status, and lifestyle factors associated with vaccinations.
This is a retrospective study involving data from the AoU program (R2020Q4R2, N = 315,297). Five vaccine cohorts [influenza, hepatitis B (HBV), pneumococcal <65 years old, pneumococcal ≥65 years old, and human papillomavirus (HPV)] were generated based on vaccination history. The influenza cohort comprised participants with documented influenza vaccinations in electronic health records (EHRs) from September 2017 to May 2018. Other vaccine cohorts comprised participants with ≥1 lifetime record(s) of vaccination documented in the EHR by December 2018. The vaccine cohorts were compared to the overall AoU cohort. Descriptive statistics were generated using EHR- and survey-based sociodemographic, health, and lifestyle information. The SAMBA (0.9.0) R package was utilized to adjust for EHR selection and outcome misclassification biases to infer sources of disparity for pneumococcal vaccinations in older adults.
Cohort counts were as follows: influenza (n = 15,346), HBV (n = 6323), pneumococcal <65 (n = 15,217), pneumococcal ≥65 (n = 15,100), and HPV (n = 2125). All vaccine cohorts had higher proportions of White and non-Hispanic/Latino participants compared to the overall AoU cohort. The largest differences were found in pneumococcal age ≥65, with 80.2% White participants compared to 52.9% in the overall study population. Multivariable analysis revealed that race/ethnic disparities in pneumococcal vaccination among older adults were explained by biological sex, income, health insurance, and education-related variables.
Racial, ethnic, education, and income characteristics differ across the vaccine cohorts among AoU participants. These findings inform future utilization of large health databases in vaccine epidemiology research and emphasize the need for more targeted interventions that address differences in vaccine uptake.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36549934</pmid><doi>10.1016/j.japh.2022.11.005</doi><orcidid>https://orcid.org/0000-0002-3009-5966</orcidid><orcidid>https://orcid.org/0000-0002-0754-7901</orcidid><orcidid>https://orcid.org/0000-0001-9308-7384</orcidid><orcidid>https://orcid.org/0000-0002-7988-3250</orcidid><orcidid>https://orcid.org/0000-0002-0254-8059</orcidid><orcidid>https://orcid.org/0000-0003-4391-4219</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1544-3191 |
| ispartof | Journal of the American Pharmacists Association, 2023-03, Vol.63 (2), p.582-591.e20 |
| issn | 1544-3191 1544-3450 |
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| subjects | Aged Humans Influenza Vaccines Influenza, Human - prevention & control Papillomavirus Infections Pneumococcal Vaccines Population Health Retrospective Studies Vaccination |
| title | Sociodemographic characteristics differ across routine adult vaccine cohorts: An All of Us descriptive study |
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