The deleterious effect of xylene-induced ear edema in rats: Protective role of dexketoprofen trometamol transdermal invasomes via inhibiting the oxidative stress/NF-κB/COX-2 pathway

[Display omitted] •Dexketoprofen trometamol transdermal invasomes containing Citral had superior results compared to Eugenol.•2.6 folds increase in drug flux was accomplished from the optimized invasomes.•An enhancement in DKT deposition in the skin layers by 3.51 folds was achieved.•Downregulation...

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Veröffentlicht in:	International journal of pharmaceutics 2023-01, Vol.631, p.122525-122525, Article 122525
Hauptverfasser:	Soliman, Sara M., Teaima, Mahmoud Hassan, Rashwan, Kareem Omar, Ali, Bassam Mohamed, Jasti, Bhaskara R., El-Nabarawi, Mohamed A, Abd El-Halim, Shady M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology COX-2 Cyclooxygenase 2 - adverse effects Cyclooxygenase 2 - metabolism Dexketoprofen trometamol Edema - chemically induced Edema - drug therapy Invasomes NF-kappa B - metabolism NF-κB p65 Oxidative Stress Quality of Life Rats Transdermal Xylene-induced ear edema Xylenes
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