Linear structural features of Wilson’s disease and its correlation with neurological symptoms
To measure the linear structure of the brain in patients with Wilson’s disease (WD) and analyze its correlation with neurological symptoms. A total of 174 patients diagnosed with WD were enrolled. According to the type of clinical presentation, the patients with WD were divided into two groupsneurol...
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| Veröffentlicht in: | Medicine (Baltimore) 2022-12, Vol.101 (50), p.e31386-e31386 |
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| creator | Diao, Sheng-Peng Lǚ, Chun-Xiao Huang, Ye-Qing Zhou, Zhi-Hua Liu, Ai-Qun Hong, Ming-Fan |
| description | To measure the linear structure of the brain in patients with Wilson’s disease (WD) and analyze its correlation with neurological symptoms. A total of 174 patients diagnosed with WD were enrolled. According to the type of clinical presentation, the patients with WD were divided into two groupsneurological (NWD) and hepatic (HWD). Sixty healthy volunteers were assigned to a control group. All patients with WD and healthy controls underwent brain magnetic resonance imaging (MRI). The severity of the neurological symptoms was assessed using the Burke Fahn Marsden Movement subscale (BFM-M). Linear brain measurements were performed using T1-weighted MRI scans of all the patients, and the correlation between these linear indices and BFM-M score was investigated. The Huckman index, third ventricle width, and sulcus width of the NWD group were significantly higher than those of the HWD and control groups (
P
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| doi_str_mv | 10.1097/MD.0000000000031386 |
| format | Article |
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P
< .05). The frontal horn index, ventricular index, and lateral ventricular body width index of the NWD group were significantly lower than those of the HWD and control groups (
P
< .05). The Huckman index and third ventricle width of the HWD group were higher than those of the control group (
P
< .05), whereas the body width index of the lateral ventricle was lower than that of the control group (
P
< .05). The BFM-M score correlated with the Huckman index (
r
= 0.29,
P
< .05), third ventricle width (
r
= 0.426,
P
< .001), and lateral ventricular body width index (
r
= −0.19,
P
< .05). This study demonstrated significant changes in the linear structure of patients with WD. Linear brain measurement analysis could be used as a potential method to assess the severity of neurological symptoms in WD.]]></description><identifier>ISSN: 1536-5964</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000031386</identifier><identifier>PMID: 36550817</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Brain - pathology ; Hepatolenticular Degeneration - diagnosis ; Humans ; Magnetic Resonance Imaging</subject><ispartof>Medicine (Baltimore), 2022-12, Vol.101 (50), p.e31386-e31386</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3455-e73e41e91f6c9abe937e0b364da131ed17d7fdc9b4c979dfa5edbf9a66ff04633</cites><orcidid>0000-0002-2680-167 ; 0000-0002-2680-167X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36550817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diao, Sheng-Peng</creatorcontrib><creatorcontrib>Lǚ, Chun-Xiao</creatorcontrib><creatorcontrib>Huang, Ye-Qing</creatorcontrib><creatorcontrib>Zhou, Zhi-Hua</creatorcontrib><creatorcontrib>Liu, Ai-Qun</creatorcontrib><creatorcontrib>Hong, Ming-Fan</creatorcontrib><title>Linear structural features of Wilson’s disease and its correlation with neurological symptoms</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description><![CDATA[To measure the linear structure of the brain in patients with Wilson’s disease (WD) and analyze its correlation with neurological symptoms. A total of 174 patients diagnosed with WD were enrolled. According to the type of clinical presentation, the patients with WD were divided into two groupsneurological (NWD) and hepatic (HWD). Sixty healthy volunteers were assigned to a control group. All patients with WD and healthy controls underwent brain magnetic resonance imaging (MRI). The severity of the neurological symptoms was assessed using the Burke Fahn Marsden Movement subscale (BFM-M). Linear brain measurements were performed using T1-weighted MRI scans of all the patients, and the correlation between these linear indices and BFM-M score was investigated. The Huckman index, third ventricle width, and sulcus width of the NWD group were significantly higher than those of the HWD and control groups (
P
< .05). The frontal horn index, ventricular index, and lateral ventricular body width index of the NWD group were significantly lower than those of the HWD and control groups (
P
< .05). The Huckman index and third ventricle width of the HWD group were higher than those of the control group (
P
< .05), whereas the body width index of the lateral ventricle was lower than that of the control group (
P
< .05). The BFM-M score correlated with the Huckman index (
r
= 0.29,
P
< .05), third ventricle width (
r
= 0.426,
P
< .001), and lateral ventricular body width index (
r
= −0.19,
P
< .05). This study demonstrated significant changes in the linear structure of patients with WD. Linear brain measurement analysis could be used as a potential method to assess the severity of neurological symptoms in WD.]]></description><subject>Brain - pathology</subject><subject>Hepatolenticular Degeneration - diagnosis</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><issn>1536-5964</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEmOFDEQRVMIRA9wAiTkJZts7PRUXqJuhpaqxQbE0nLaYcrgTBcOp0q94xpcj5OQUM0gYhNfofd_SL_rnjB6wajRz2-uLujf4Yxv1L3ulEmuemmUuP-PPunOED9RyrgexMPuhCsp6Ybp085u0wyuEmx18W2pLpMIbhWApETyIWUs8_ev35CEhOAQiJsDSQ2JL7VCdi2VmRxS25EZllpy-Zj8GoK3076VCR91D6LLCI_v9nn3_tXLd5dv-u3b19eXL7a950LKHjQHwcCwqLxxIxiugY5cieAYZxCYDjoGb0bhjTYhOglhjMYpFSMVivPz7tkxd1_LlwWw2Smhh5zdDGVBO2i5oWZjBF1RfkR9LYgVot3XNLl6axm1P5u1N1f2_2ZX19O7B8s4Qfjj-V3lCogjcCi5QcXPeTlAtTtwue1-5Ulthn6gw8AGpmi_XgbJfwCJnIaW</recordid><startdate>20221216</startdate><enddate>20221216</enddate><creator>Diao, Sheng-Peng</creator><creator>Lǚ, Chun-Xiao</creator><creator>Huang, Ye-Qing</creator><creator>Zhou, Zhi-Hua</creator><creator>Liu, Ai-Qun</creator><creator>Hong, Ming-Fan</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2680-167</orcidid><orcidid>https://orcid.org/0000-0002-2680-167X</orcidid></search><sort><creationdate>20221216</creationdate><title>Linear structural features of Wilson’s disease and its correlation with neurological symptoms</title><author>Diao, Sheng-Peng ; Lǚ, Chun-Xiao ; Huang, Ye-Qing ; Zhou, Zhi-Hua ; Liu, Ai-Qun ; Hong, Ming-Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3455-e73e41e91f6c9abe937e0b364da131ed17d7fdc9b4c979dfa5edbf9a66ff04633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Brain - pathology</topic><topic>Hepatolenticular Degeneration - diagnosis</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diao, Sheng-Peng</creatorcontrib><creatorcontrib>Lǚ, Chun-Xiao</creatorcontrib><creatorcontrib>Huang, Ye-Qing</creatorcontrib><creatorcontrib>Zhou, Zhi-Hua</creatorcontrib><creatorcontrib>Liu, Ai-Qun</creatorcontrib><creatorcontrib>Hong, Ming-Fan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diao, Sheng-Peng</au><au>Lǚ, Chun-Xiao</au><au>Huang, Ye-Qing</au><au>Zhou, Zhi-Hua</au><au>Liu, Ai-Qun</au><au>Hong, Ming-Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linear structural features of Wilson’s disease and its correlation with neurological symptoms</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2022-12-16</date><risdate>2022</risdate><volume>101</volume><issue>50</issue><spage>e31386</spage><epage>e31386</epage><pages>e31386-e31386</pages><issn>1536-5964</issn><eissn>1536-5964</eissn><abstract><![CDATA[To measure the linear structure of the brain in patients with Wilson’s disease (WD) and analyze its correlation with neurological symptoms. A total of 174 patients diagnosed with WD were enrolled. According to the type of clinical presentation, the patients with WD were divided into two groupsneurological (NWD) and hepatic (HWD). Sixty healthy volunteers were assigned to a control group. All patients with WD and healthy controls underwent brain magnetic resonance imaging (MRI). The severity of the neurological symptoms was assessed using the Burke Fahn Marsden Movement subscale (BFM-M). Linear brain measurements were performed using T1-weighted MRI scans of all the patients, and the correlation between these linear indices and BFM-M score was investigated. The Huckman index, third ventricle width, and sulcus width of the NWD group were significantly higher than those of the HWD and control groups (
P
< .05). The frontal horn index, ventricular index, and lateral ventricular body width index of the NWD group were significantly lower than those of the HWD and control groups (
P
< .05). The Huckman index and third ventricle width of the HWD group were higher than those of the control group (
P
< .05), whereas the body width index of the lateral ventricle was lower than that of the control group (
P
< .05). The BFM-M score correlated with the Huckman index (
r
= 0.29,
P
< .05), third ventricle width (
r
= 0.426,
P
< .001), and lateral ventricular body width index (
r
= −0.19,
P
< .05). This study demonstrated significant changes in the linear structure of patients with WD. Linear brain measurement analysis could be used as a potential method to assess the severity of neurological symptoms in WD.]]></abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>36550817</pmid><doi>10.1097/MD.0000000000031386</doi><orcidid>https://orcid.org/0000-0002-2680-167</orcidid><orcidid>https://orcid.org/0000-0002-2680-167X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Brain - pathology Hepatolenticular Degeneration - diagnosis Humans Magnetic Resonance Imaging |
| title | Linear structural features of Wilson’s disease and its correlation with neurological symptoms |
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