Pediatric and elderly polymorphous low‐grade neuroepithelial tumor of the young: Typical and unusual case reports and literature review
Polymorphous low‐grade neuroepithelial tumor of the young (PLNTY), one of the pediatric‐type diffuse low‐grade gliomas, is characterized by a diffuse infiltrating pattern of oligodendroglioma‐like tumor cells showing CD34 positivity and harbors mitogen‐activated protein kinase (MAPK) alteration, suc...
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| Veröffentlicht in: | Neuropathology 2023-08, Vol.43 (4), p.319-325 |
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| creator | Furuta, Takuya Moritsubo, Mayuko Muta, Hiroko Shimamoto, Hotetsu Ohshima, Koichi Sugita, Yasuo |
| description | Polymorphous low‐grade neuroepithelial tumor of the young (PLNTY), one of the pediatric‐type diffuse low‐grade gliomas, is characterized by a diffuse infiltrating pattern of oligodendroglioma‐like tumor cells showing CD34 positivity and harbors mitogen‐activated protein kinase (MAPK) alteration, such as vRAF murine sarcoma viral oncogene homolog B1 (BRAF) p.V600E or fibroblast growth factor fusion genetically. It occurs mainly in pediatric and adolescents with seizures due to the dominant location of the temporal lobe. However, there have been a few cases of PLNTY in adult patients, suggesting the wide range of this tumor spectrum. Here, we describe two cases of PLNTY, one in a 14‐year‐old female and the other in a 66‐year‐old female. The pediatric tumor showed typical clinical course and histopathology with BRAF p.V600E mutation, whereas the elderly tumor was unusual because of non‐epileptic onset clinically and ependymal differentiation histopathologically harboring KIAA1549‐BRAF fusion. There might be unusual but possible PLNTY, as in our elderly case. We also compared typical pediatric and unusual elderly tumors by reviewing the literature. |
| doi_str_mv | 10.1111/neup.12889 |
| format | Article |
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It occurs mainly in pediatric and adolescents with seizures due to the dominant location of the temporal lobe. However, there have been a few cases of PLNTY in adult patients, suggesting the wide range of this tumor spectrum. Here, we describe two cases of PLNTY, one in a 14‐year‐old female and the other in a 66‐year‐old female. The pediatric tumor showed typical clinical course and histopathology with BRAF p.V600E mutation, whereas the elderly tumor was unusual because of non‐epileptic onset clinically and ependymal differentiation histopathologically harboring KIAA1549‐BRAF fusion. There might be unusual but possible PLNTY, as in our elderly case. We also compared typical pediatric and unusual elderly tumors by reviewing the literature.</description><identifier>ISSN: 0919-6544</identifier><identifier>EISSN: 1440-1789</identifier><identifier>DOI: 10.1111/neup.12889</identifier><identifier>PMID: 36545913</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Adolescent ; Aged ; Animals ; Brain cancer ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Brain tumors ; Case reports ; CD34 antigen ; Child ; Epilepsy ; Female ; Glioma ; Glioma - genetics ; glioneuronal tumor ; Humans ; Kinases ; Literature reviews ; long‐term epilepsy‐associated tumors ; low‐grade glioma ; MAP kinase ; Mice ; Mutation ; Neoplasms, Neuroepithelial - genetics ; Neoplasms, Neuroepithelial - pathology ; Older people ; Oligodendroglioma ; Oligodendroglioma - genetics ; Pediatrics ; polymorphous low‐grade neuroepithelial tumor of the young ; Proto-Oncogene Proteins B-raf - genetics ; Sarcoma ; Seizures ; Temporal lobe ; Tumor cells</subject><ispartof>Neuropathology, 2023-08, Vol.43 (4), p.319-325</ispartof><rights>2022 Japanese Society of Neuropathology.</rights><rights>2023 Japanese Society of Neuropathology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3819-ca835363d9418d491dd45a3273ff11efcd89aeadb8f700ef958961690827a7c23</citedby><cites>FETCH-LOGICAL-c3819-ca835363d9418d491dd45a3273ff11efcd89aeadb8f700ef958961690827a7c23</cites><orcidid>0000-0001-8925-8961 ; 0000-0002-7250-457X ; 0000-0002-6645-7818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fneup.12889$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fneup.12889$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36545913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furuta, Takuya</creatorcontrib><creatorcontrib>Moritsubo, Mayuko</creatorcontrib><creatorcontrib>Muta, Hiroko</creatorcontrib><creatorcontrib>Shimamoto, Hotetsu</creatorcontrib><creatorcontrib>Ohshima, Koichi</creatorcontrib><creatorcontrib>Sugita, Yasuo</creatorcontrib><title>Pediatric and elderly polymorphous low‐grade neuroepithelial tumor of the young: Typical and unusual case reports and literature review</title><title>Neuropathology</title><addtitle>Neuropathology</addtitle><description>Polymorphous low‐grade neuroepithelial tumor of the young (PLNTY), one of the pediatric‐type diffuse low‐grade gliomas, is characterized by a diffuse infiltrating pattern of oligodendroglioma‐like tumor cells showing CD34 positivity and harbors mitogen‐activated protein kinase (MAPK) alteration, such as vRAF murine sarcoma viral oncogene homolog B1 (BRAF) p.V600E or fibroblast growth factor fusion genetically. It occurs mainly in pediatric and adolescents with seizures due to the dominant location of the temporal lobe. However, there have been a few cases of PLNTY in adult patients, suggesting the wide range of this tumor spectrum. Here, we describe two cases of PLNTY, one in a 14‐year‐old female and the other in a 66‐year‐old female. The pediatric tumor showed typical clinical course and histopathology with BRAF p.V600E mutation, whereas the elderly tumor was unusual because of non‐epileptic onset clinically and ependymal differentiation histopathologically harboring KIAA1549‐BRAF fusion. There might be unusual but possible PLNTY, as in our elderly case. We also compared typical pediatric and unusual elderly tumors by reviewing the literature.</description><subject>Adolescent</subject><subject>Aged</subject><subject>Animals</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain tumors</subject><subject>Case reports</subject><subject>CD34 antigen</subject><subject>Child</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - genetics</subject><subject>glioneuronal tumor</subject><subject>Humans</subject><subject>Kinases</subject><subject>Literature reviews</subject><subject>long‐term epilepsy‐associated tumors</subject><subject>low‐grade glioma</subject><subject>MAP kinase</subject><subject>Mice</subject><subject>Mutation</subject><subject>Neoplasms, Neuroepithelial - genetics</subject><subject>Neoplasms, Neuroepithelial - pathology</subject><subject>Older people</subject><subject>Oligodendroglioma</subject><subject>Oligodendroglioma - genetics</subject><subject>Pediatrics</subject><subject>polymorphous low‐grade neuroepithelial tumor of the young</subject><subject>Proto-Oncogene Proteins B-raf - genetics</subject><subject>Sarcoma</subject><subject>Seizures</subject><subject>Temporal lobe</subject><subject>Tumor cells</subject><issn>0919-6544</issn><issn>1440-1789</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kbFOHDEQhi2UCA5CwwNEltJEkY7Ya-_aThchQiKhhAJqy9izYORbb-x1TtulpeMZeRJ8HEmRItN49M-nfzz6ETqi5JjW-jhAGY9pI6XaQQvKOVlSIdUrtCCKqmXXcr6H9nO-I4QK1chdtMeq2CrKFuj-Apw3U_IWm8FhCA5SmPEYw7yKabyNJeMQ14-_H26ScYDrrhRh9NMtBG8CnkrFcOxxFfAcy3DzCV_Oo7d1tjEsQ8ml9tZkwAnGmKb8PAh-gmSmkjbyLw_rN-h1b0KGw5f3AF19Ob08-bo8_3H27eTz-dIyWc-xRrKWdcwpTqXjijrHW8MawfqeUuitk8qAcdeyF4RAr1qpOtopIhthhG3YAXq_9R1T_FkgT3rls4UQzAD1Wt2IVpC2E1xU9N0_6F0saai_043knHWKS1apD1vKpphzgl6Pya9MmjUlehOQ3gSknwOq8NsXy3K9AvcX_ZNIBegWWPsA83-s9PfTq4ut6RPD7575</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Furuta, Takuya</creator><creator>Moritsubo, Mayuko</creator><creator>Muta, Hiroko</creator><creator>Shimamoto, Hotetsu</creator><creator>Ohshima, Koichi</creator><creator>Sugita, Yasuo</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8925-8961</orcidid><orcidid>https://orcid.org/0000-0002-7250-457X</orcidid><orcidid>https://orcid.org/0000-0002-6645-7818</orcidid></search><sort><creationdate>202308</creationdate><title>Pediatric and elderly polymorphous low‐grade neuroepithelial tumor of the young: Typical and unusual case reports and literature review</title><author>Furuta, Takuya ; Moritsubo, Mayuko ; Muta, Hiroko ; Shimamoto, Hotetsu ; Ohshima, Koichi ; Sugita, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3819-ca835363d9418d491dd45a3273ff11efcd89aeadb8f700ef958961690827a7c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Aged</topic><topic>Animals</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain tumors</topic><topic>Case reports</topic><topic>CD34 antigen</topic><topic>Child</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Glioma</topic><topic>Glioma - genetics</topic><topic>glioneuronal tumor</topic><topic>Humans</topic><topic>Kinases</topic><topic>Literature reviews</topic><topic>long‐term epilepsy‐associated tumors</topic><topic>low‐grade glioma</topic><topic>MAP kinase</topic><topic>Mice</topic><topic>Mutation</topic><topic>Neoplasms, Neuroepithelial - genetics</topic><topic>Neoplasms, Neuroepithelial - pathology</topic><topic>Older people</topic><topic>Oligodendroglioma</topic><topic>Oligodendroglioma - genetics</topic><topic>Pediatrics</topic><topic>polymorphous low‐grade neuroepithelial tumor of the young</topic><topic>Proto-Oncogene Proteins B-raf - genetics</topic><topic>Sarcoma</topic><topic>Seizures</topic><topic>Temporal lobe</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furuta, Takuya</creatorcontrib><creatorcontrib>Moritsubo, Mayuko</creatorcontrib><creatorcontrib>Muta, Hiroko</creatorcontrib><creatorcontrib>Shimamoto, Hotetsu</creatorcontrib><creatorcontrib>Ohshima, Koichi</creatorcontrib><creatorcontrib>Sugita, Yasuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furuta, Takuya</au><au>Moritsubo, Mayuko</au><au>Muta, Hiroko</au><au>Shimamoto, Hotetsu</au><au>Ohshima, Koichi</au><au>Sugita, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric and elderly polymorphous low‐grade neuroepithelial tumor of the young: Typical and unusual case reports and literature review</atitle><jtitle>Neuropathology</jtitle><addtitle>Neuropathology</addtitle><date>2023-08</date><risdate>2023</risdate><volume>43</volume><issue>4</issue><spage>319</spage><epage>325</epage><pages>319-325</pages><issn>0919-6544</issn><eissn>1440-1789</eissn><abstract>Polymorphous low‐grade neuroepithelial tumor of the young (PLNTY), one of the pediatric‐type diffuse low‐grade gliomas, is characterized by a diffuse infiltrating pattern of oligodendroglioma‐like tumor cells showing CD34 positivity and harbors mitogen‐activated protein kinase (MAPK) alteration, such as vRAF murine sarcoma viral oncogene homolog B1 (BRAF) p.V600E or fibroblast growth factor fusion genetically. It occurs mainly in pediatric and adolescents with seizures due to the dominant location of the temporal lobe. However, there have been a few cases of PLNTY in adult patients, suggesting the wide range of this tumor spectrum. Here, we describe two cases of PLNTY, one in a 14‐year‐old female and the other in a 66‐year‐old female. The pediatric tumor showed typical clinical course and histopathology with BRAF p.V600E mutation, whereas the elderly tumor was unusual because of non‐epileptic onset clinically and ependymal differentiation histopathologically harboring KIAA1549‐BRAF fusion. There might be unusual but possible PLNTY, as in our elderly case. We also compared typical pediatric and unusual elderly tumors by reviewing the literature.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>36545913</pmid><doi>10.1111/neup.12889</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8925-8961</orcidid><orcidid>https://orcid.org/0000-0002-7250-457X</orcidid><orcidid>https://orcid.org/0000-0002-6645-7818</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Aged Animals Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Case reports CD34 antigen Child Epilepsy Female Glioma Glioma - genetics glioneuronal tumor Humans Kinases Literature reviews long‐term epilepsy‐associated tumors low‐grade glioma MAP kinase Mice Mutation Neoplasms, Neuroepithelial - genetics Neoplasms, Neuroepithelial - pathology Older people Oligodendroglioma Oligodendroglioma - genetics Pediatrics polymorphous low‐grade neuroepithelial tumor of the young Proto-Oncogene Proteins B-raf - genetics Sarcoma Seizures Temporal lobe Tumor cells |
| title | Pediatric and elderly polymorphous low‐grade neuroepithelial tumor of the young: Typical and unusual case reports and literature review |
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