Evidence of Residual Ongoing Viral Replication in Chronic Hepatitis B Patients Successfully Treated With Nucleos(t)ide Analogues

Abstract Background Chronic hepatitis B is usually treated with nucleos(t)ide analogues (NAs). However, a cure is rarely achieved, even with years of treatment. Here, we investigated whether viral replication is completely halted and how long covalently closed circular DNA (cccDNA) persists in patie...

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Veröffentlicht in:	The Journal of infectious diseases 2023-03, Vol.227 (5), p.675-685
Hauptverfasser:	Yu, Tong, Zhang, Miaoqu, Zhang, Hanyue, Zheng, Jianming, Shen, Chuan, Jiang, Ning, Zou, Lei, Wang, Jing, Yu, Yiqi, Zhang, Qiran, Yu, Shuili, Huang, Yanfang, Huang, Yuxian, Zhang, Jiming, Qiu, Chao, Zhang, Wenhong, Meng, Zhefeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - therapeutic use Biopsy Circular DNA Cross-Sectional Studies DNA, Circular DNA, Viral - genetics Hepatitis B Hepatitis B - drug therapy Hepatitis B virus - genetics Hepatitis B, Chronic - drug therapy Hepatocytes Humans Hybridization Intermediates Liver Nucleocapsids Replication Virus Replication
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