Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis

Lysine crotonylation as a protein post-translational modification regulates diverse cellular processes and functions. However, the role of crotonylation in nutrient signaling pathways remains unclear. Here, we find a positive correlation between global crotonylation levels and leucine-deprivation-in...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-12, Vol.41 (12), p.111850-111850, Article 111850
Hauptverfasser:	Zheng, Zilong, Yan, Guokai, Li, Xiuzhi, Fei, Yuke, Sun, Lingling, Yu, Haonan, Niu, Yaorong, Gao, Weihua, Zhong, Qing, Yan, Xianghua
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism 14-3-3ε Autophagy crotonylation HDAC7 Leucine - metabolism leucine deprivation Lysine - metabolism Phosphoric Monoester Hydrolases - metabolism PPM1B Protein Processing, Post-Translational
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