Pulmonary hypertension with a precapillary component in heart failure with preserved ejection fraction
ObjectivesHeart failure with preserved ejection fraction (HFpEF) is often complicated by pulmonary hypertension (PH), which is mainly characterised by postcapillary PH and occasionally accompanied by a precapillary component of PH. Haemodynamic changes in worsening heart failure (HF) can modify the...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2023-04, Vol.109 (8), p.626-633 |
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| creator | Sera, Fusako Ohtani, Tomohito Tamaki, Shunsuke Yano, Masamichi Hayashi, Takaharu Nakagawa, Akito Nakagawa, Yusuke Nakatani, Daisaku Yamada, Takahisa Yasumura, Yoshio Hikoso, Shungo Yamauchi-Takihara, Keiko Sakata, Yasushi |
| description | ObjectivesHeart failure with preserved ejection fraction (HFpEF) is often complicated by pulmonary hypertension (PH), which is mainly characterised by postcapillary PH and occasionally accompanied by a precapillary component of PH. Haemodynamic changes in worsening heart failure (HF) can modify the characteristics of PH. However, the clinical features of PH after HF treatment in HFpEF remain unclear. We investigated the prevalence and clinical significance of the precapillary component of PH after HF treatment in HFpEF, using data from the Prospective Multicentre Observational Study of Patients with HFpEF (PURSUIT-HFpEF).MethodsFrom the PURSUIT-HFpEF registry, 219 patients hospitalised with acute HF who underwent right heart catheterisation after initial HF treatment were divided into four groups according to the 2015 and 2018 PH definitions: non-PH, isolated postcapillary pulmonary hypertension (Ipc-PH), precapillary PH and combined postcapillary and precapillary pulmonary hypertension (Cpc-PH). The latter two were combined as PH with the precapillary component.ResultsUsing the 2015 definition, we found that the prevalence of PH after HF treatment was 27% (Ipc-PH: 20%, precapillary PH: 3%, Cpc-PH: 4%). Applying the 2018 definition resulted in a doubled frequency of precapillary PH (6%). PH with a precapillary component according to the 2015 definition was associated with poor clinical outcomes and characterised by small left ventricular dimension and high early diastolic mitral inflow velocity/early diastolic mitral annular tissue velocity.ConclusionAfter initial HF treatment, 7% of hospitalised patients with HFpEF had precapillary component of PH according to the 2015 definition. Echocardiographic parameters of the left ventricle can contribute to the risk stratification of patients with HFpEF with a precapillary component of PH. |
| doi_str_mv | 10.1136/heartjnl-2022-321565 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2757053909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2791110400</sourcerecordid><originalsourceid>FETCH-LOGICAL-b404t-bcfac62c747911f0360b5934a08ff9d61c7c523e945e9c399ed2ac82c109b9e73</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxUVpaTbbfoMSDL304nT016tjCGkbCCSHBHozsnbE2tiyI9kJ-faR42wCOexphuE37w3zCPlB4ZRSrn7v0ISx8W3OgLGcMyqV_ERWVKhNGtH_n1PPpcwV8OKIHMfYAIDQG_WVHHElBZdUr4i7mdqu9yY8ZbunAcOIPta9zx7rcZeZbAhozVC37QzYvht6j37Map-92GfO1O0UcMETHDE84DbDBu04y7hgXppv5IszbcTvr3VN7v5c3J7_y6-u_16en13llQAx5pV1xipmC1FoSh1wBZXUXBjYOKe3itrCSsZRC4nacq1xy4zdMEtBVxoLvia_Ft0h9PcTxrHs6mgx3e-xn2LJClmA5Bp0Qn9-QJt-Cj5dl6jkTkEAHKakSs-VTCVKLJQNfYwBXTmEuks_KymUc1rlPq1yTqtc0kprJ6_iU9Xh9m1pH08CYAGqrnk3Pqj5DNTmorc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2756603526</pqid></control><display><type>article</type><title>Pulmonary hypertension with a precapillary component in heart failure with preserved ejection fraction</title><source>MEDLINE</source><source>PubMed Central</source><creator>Sera, Fusako ; Ohtani, Tomohito ; Tamaki, Shunsuke ; Yano, Masamichi ; Hayashi, Takaharu ; Nakagawa, Akito ; Nakagawa, Yusuke ; Nakatani, Daisaku ; Yamada, Takahisa ; Yasumura, Yoshio ; Hikoso, Shungo ; Yamauchi-Takihara, Keiko ; Sakata, Yasushi</creator><creatorcontrib>Sera, Fusako ; Ohtani, Tomohito ; Tamaki, Shunsuke ; Yano, Masamichi ; Hayashi, Takaharu ; Nakagawa, Akito ; Nakagawa, Yusuke ; Nakatani, Daisaku ; Yamada, Takahisa ; Yasumura, Yoshio ; Hikoso, Shungo ; Yamauchi-Takihara, Keiko ; Sakata, Yasushi ; Osaka Cardiovascular Conference (OCVC)-Heart Failure Investigators</creatorcontrib><description>ObjectivesHeart failure with preserved ejection fraction (HFpEF) is often complicated by pulmonary hypertension (PH), which is mainly characterised by postcapillary PH and occasionally accompanied by a precapillary component of PH. Haemodynamic changes in worsening heart failure (HF) can modify the characteristics of PH. However, the clinical features of PH after HF treatment in HFpEF remain unclear. We investigated the prevalence and clinical significance of the precapillary component of PH after HF treatment in HFpEF, using data from the Prospective Multicentre Observational Study of Patients with HFpEF (PURSUIT-HFpEF).MethodsFrom the PURSUIT-HFpEF registry, 219 patients hospitalised with acute HF who underwent right heart catheterisation after initial HF treatment were divided into four groups according to the 2015 and 2018 PH definitions: non-PH, isolated postcapillary pulmonary hypertension (Ipc-PH), precapillary PH and combined postcapillary and precapillary pulmonary hypertension (Cpc-PH). The latter two were combined as PH with the precapillary component.ResultsUsing the 2015 definition, we found that the prevalence of PH after HF treatment was 27% (Ipc-PH: 20%, precapillary PH: 3%, Cpc-PH: 4%). Applying the 2018 definition resulted in a doubled frequency of precapillary PH (6%). PH with a precapillary component according to the 2015 definition was associated with poor clinical outcomes and characterised by small left ventricular dimension and high early diastolic mitral inflow velocity/early diastolic mitral annular tissue velocity.ConclusionAfter initial HF treatment, 7% of hospitalised patients with HFpEF had precapillary component of PH according to the 2015 definition. Echocardiographic parameters of the left ventricle can contribute to the risk stratification of patients with HFpEF with a precapillary component of PH.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2022-321565</identifier><identifier>PMID: 36543519</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Cardiac catheterization ; Cardiology ; Cardiovascular disease ; echocardiography ; Echocardiography - methods ; Ejection fraction ; haemodynamics ; Heart failure ; Heart Failure - complications ; Heart Failure - diagnosis ; Heart Failure - epidemiology ; Heart failure and cardiomyopathies ; Hemodynamics ; Humans ; hypertension, pulmonary ; Hypertension, Pulmonary - complications ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - epidemiology ; Patients ; Prospective Studies ; Pulmonary arteries ; Pulmonary hypertension ; Stroke Volume ; Velocity</subject><ispartof>Heart (British Cardiac Society), 2023-04, Vol.109 (8), p.626-633</ispartof><rights>Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2022 Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2023 Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b404t-bcfac62c747911f0360b5934a08ff9d61c7c523e945e9c399ed2ac82c109b9e73</citedby><cites>FETCH-LOGICAL-b404t-bcfac62c747911f0360b5934a08ff9d61c7c523e945e9c399ed2ac82c109b9e73</cites><orcidid>0000-0002-9260-6901 ; 0000-0003-2284-1970 ; 0000-0001-8276-1505</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36543519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sera, Fusako</creatorcontrib><creatorcontrib>Ohtani, Tomohito</creatorcontrib><creatorcontrib>Tamaki, Shunsuke</creatorcontrib><creatorcontrib>Yano, Masamichi</creatorcontrib><creatorcontrib>Hayashi, Takaharu</creatorcontrib><creatorcontrib>Nakagawa, Akito</creatorcontrib><creatorcontrib>Nakagawa, Yusuke</creatorcontrib><creatorcontrib>Nakatani, Daisaku</creatorcontrib><creatorcontrib>Yamada, Takahisa</creatorcontrib><creatorcontrib>Yasumura, Yoshio</creatorcontrib><creatorcontrib>Hikoso, Shungo</creatorcontrib><creatorcontrib>Yamauchi-Takihara, Keiko</creatorcontrib><creatorcontrib>Sakata, Yasushi</creatorcontrib><creatorcontrib>Osaka Cardiovascular Conference (OCVC)-Heart Failure Investigators</creatorcontrib><title>Pulmonary hypertension with a precapillary component in heart failure with preserved ejection fraction</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><addtitle>Heart</addtitle><description>ObjectivesHeart failure with preserved ejection fraction (HFpEF) is often complicated by pulmonary hypertension (PH), which is mainly characterised by postcapillary PH and occasionally accompanied by a precapillary component of PH. Haemodynamic changes in worsening heart failure (HF) can modify the characteristics of PH. However, the clinical features of PH after HF treatment in HFpEF remain unclear. We investigated the prevalence and clinical significance of the precapillary component of PH after HF treatment in HFpEF, using data from the Prospective Multicentre Observational Study of Patients with HFpEF (PURSUIT-HFpEF).MethodsFrom the PURSUIT-HFpEF registry, 219 patients hospitalised with acute HF who underwent right heart catheterisation after initial HF treatment were divided into four groups according to the 2015 and 2018 PH definitions: non-PH, isolated postcapillary pulmonary hypertension (Ipc-PH), precapillary PH and combined postcapillary and precapillary pulmonary hypertension (Cpc-PH). The latter two were combined as PH with the precapillary component.ResultsUsing the 2015 definition, we found that the prevalence of PH after HF treatment was 27% (Ipc-PH: 20%, precapillary PH: 3%, Cpc-PH: 4%). Applying the 2018 definition resulted in a doubled frequency of precapillary PH (6%). PH with a precapillary component according to the 2015 definition was associated with poor clinical outcomes and characterised by small left ventricular dimension and high early diastolic mitral inflow velocity/early diastolic mitral annular tissue velocity.ConclusionAfter initial HF treatment, 7% of hospitalised patients with HFpEF had precapillary component of PH according to the 2015 definition. Echocardiographic parameters of the left ventricle can contribute to the risk stratification of patients with HFpEF with a precapillary component of PH.</description><subject>Cardiac catheterization</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>echocardiography</subject><subject>Echocardiography - methods</subject><subject>Ejection fraction</subject><subject>haemodynamics</subject><subject>Heart failure</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - epidemiology</subject><subject>Heart failure and cardiomyopathies</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>hypertension, pulmonary</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - epidemiology</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Pulmonary arteries</subject><subject>Pulmonary hypertension</subject><subject>Stroke Volume</subject><subject>Velocity</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9r3DAQxUVpaTbbfoMSDL304nT016tjCGkbCCSHBHozsnbE2tiyI9kJ-faR42wCOexphuE37w3zCPlB4ZRSrn7v0ISx8W3OgLGcMyqV_ERWVKhNGtH_n1PPpcwV8OKIHMfYAIDQG_WVHHElBZdUr4i7mdqu9yY8ZbunAcOIPta9zx7rcZeZbAhozVC37QzYvht6j37Map-92GfO1O0UcMETHDE84DbDBu04y7hgXppv5IszbcTvr3VN7v5c3J7_y6-u_16en13llQAx5pV1xipmC1FoSh1wBZXUXBjYOKe3itrCSsZRC4nacq1xy4zdMEtBVxoLvia_Ft0h9PcTxrHs6mgx3e-xn2LJClmA5Bp0Qn9-QJt-Cj5dl6jkTkEAHKakSs-VTCVKLJQNfYwBXTmEuks_KymUc1rlPq1yTqtc0kprJ6_iU9Xh9m1pH08CYAGqrnk3Pqj5DNTmorc</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Sera, Fusako</creator><creator>Ohtani, Tomohito</creator><creator>Tamaki, Shunsuke</creator><creator>Yano, Masamichi</creator><creator>Hayashi, Takaharu</creator><creator>Nakagawa, Akito</creator><creator>Nakagawa, Yusuke</creator><creator>Nakatani, Daisaku</creator><creator>Yamada, Takahisa</creator><creator>Yasumura, Yoshio</creator><creator>Hikoso, Shungo</creator><creator>Yamauchi-Takihara, Keiko</creator><creator>Sakata, Yasushi</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9260-6901</orcidid><orcidid>https://orcid.org/0000-0003-2284-1970</orcidid><orcidid>https://orcid.org/0000-0001-8276-1505</orcidid></search><sort><creationdate>20230401</creationdate><title>Pulmonary hypertension with a precapillary component in heart failure with preserved ejection fraction</title><author>Sera, Fusako ; Ohtani, Tomohito ; Tamaki, Shunsuke ; Yano, Masamichi ; Hayashi, Takaharu ; Nakagawa, Akito ; Nakagawa, Yusuke ; Nakatani, Daisaku ; Yamada, Takahisa ; Yasumura, Yoshio ; Hikoso, Shungo ; Yamauchi-Takihara, Keiko ; Sakata, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b404t-bcfac62c747911f0360b5934a08ff9d61c7c523e945e9c399ed2ac82c109b9e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiac catheterization</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>echocardiography</topic><topic>Echocardiography - methods</topic><topic>Ejection fraction</topic><topic>haemodynamics</topic><topic>Heart failure</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - epidemiology</topic><topic>Heart failure and cardiomyopathies</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>hypertension, pulmonary</topic><topic>Hypertension, Pulmonary - complications</topic><topic>Hypertension, Pulmonary - diagnosis</topic><topic>Hypertension, Pulmonary - epidemiology</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary hypertension</topic><topic>Stroke Volume</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sera, Fusako</creatorcontrib><creatorcontrib>Ohtani, Tomohito</creatorcontrib><creatorcontrib>Tamaki, Shunsuke</creatorcontrib><creatorcontrib>Yano, Masamichi</creatorcontrib><creatorcontrib>Hayashi, Takaharu</creatorcontrib><creatorcontrib>Nakagawa, Akito</creatorcontrib><creatorcontrib>Nakagawa, Yusuke</creatorcontrib><creatorcontrib>Nakatani, Daisaku</creatorcontrib><creatorcontrib>Yamada, Takahisa</creatorcontrib><creatorcontrib>Yasumura, Yoshio</creatorcontrib><creatorcontrib>Hikoso, Shungo</creatorcontrib><creatorcontrib>Yamauchi-Takihara, Keiko</creatorcontrib><creatorcontrib>Sakata, Yasushi</creatorcontrib><creatorcontrib>Osaka Cardiovascular Conference (OCVC)-Heart Failure Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sera, Fusako</au><au>Ohtani, Tomohito</au><au>Tamaki, Shunsuke</au><au>Yano, Masamichi</au><au>Hayashi, Takaharu</au><au>Nakagawa, Akito</au><au>Nakagawa, Yusuke</au><au>Nakatani, Daisaku</au><au>Yamada, Takahisa</au><au>Yasumura, Yoshio</au><au>Hikoso, Shungo</au><au>Yamauchi-Takihara, Keiko</au><au>Sakata, Yasushi</au><aucorp>Osaka Cardiovascular Conference (OCVC)-Heart Failure Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary hypertension with a precapillary component in heart failure with preserved ejection fraction</atitle><jtitle>Heart (British Cardiac Society)</jtitle><stitle>Heart</stitle><addtitle>Heart</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>109</volume><issue>8</issue><spage>626</spage><epage>633</epage><pages>626-633</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>ObjectivesHeart failure with preserved ejection fraction (HFpEF) is often complicated by pulmonary hypertension (PH), which is mainly characterised by postcapillary PH and occasionally accompanied by a precapillary component of PH. Haemodynamic changes in worsening heart failure (HF) can modify the characteristics of PH. However, the clinical features of PH after HF treatment in HFpEF remain unclear. We investigated the prevalence and clinical significance of the precapillary component of PH after HF treatment in HFpEF, using data from the Prospective Multicentre Observational Study of Patients with HFpEF (PURSUIT-HFpEF).MethodsFrom the PURSUIT-HFpEF registry, 219 patients hospitalised with acute HF who underwent right heart catheterisation after initial HF treatment were divided into four groups according to the 2015 and 2018 PH definitions: non-PH, isolated postcapillary pulmonary hypertension (Ipc-PH), precapillary PH and combined postcapillary and precapillary pulmonary hypertension (Cpc-PH). The latter two were combined as PH with the precapillary component.ResultsUsing the 2015 definition, we found that the prevalence of PH after HF treatment was 27% (Ipc-PH: 20%, precapillary PH: 3%, Cpc-PH: 4%). Applying the 2018 definition resulted in a doubled frequency of precapillary PH (6%). PH with a precapillary component according to the 2015 definition was associated with poor clinical outcomes and characterised by small left ventricular dimension and high early diastolic mitral inflow velocity/early diastolic mitral annular tissue velocity.ConclusionAfter initial HF treatment, 7% of hospitalised patients with HFpEF had precapillary component of PH according to the 2015 definition. Echocardiographic parameters of the left ventricle can contribute to the risk stratification of patients with HFpEF with a precapillary component of PH.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>36543519</pmid><doi>10.1136/heartjnl-2022-321565</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9260-6901</orcidid><orcidid>https://orcid.org/0000-0003-2284-1970</orcidid><orcidid>https://orcid.org/0000-0001-8276-1505</orcidid></addata></record> |
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| subjects | Cardiac catheterization Cardiology Cardiovascular disease echocardiography Echocardiography - methods Ejection fraction haemodynamics Heart failure Heart Failure - complications Heart Failure - diagnosis Heart Failure - epidemiology Heart failure and cardiomyopathies Hemodynamics Humans hypertension, pulmonary Hypertension, Pulmonary - complications Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - epidemiology Patients Prospective Studies Pulmonary arteries Pulmonary hypertension Stroke Volume Velocity |
| title | Pulmonary hypertension with a precapillary component in heart failure with preserved ejection fraction |
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