SNAC for Enhanced Oral Bioavailability: An Updated Review
The delivery of proteins and peptides via an oral route poses numerous challenges to improve the oral bioavailability and patient compliance. To overcome these challenges, as well as to improve the permeation of proteins and peptides via intestinal mucosa, several chemicals have been studied such...
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| Veröffentlicht in: | Pharmaceutical research 2023-03, Vol.40 (3), p.633-650 |
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| creator | Kommineni, Nagavendra Sainaga Jyothi, Vaskuri G S Butreddy, Arun Raju, Saka Shapira, Tovi Khan, Wahid Angsantikul, Pavimol Domb, Abraham J. |
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The delivery of proteins and peptides via an oral route poses numerous challenges to improve the oral bioavailability and patient compliance. To overcome these challenges, as well as to improve the permeation of proteins and peptides via intestinal mucosa, several chemicals have been studied such as surfactants, fatty acids, bile salts, pH modifiers, and chelating agents, amongst these medium chain fatty acid like C10 (sodium caprate) and Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC) and its derivatives that have been well studied from a clinical perspective. This current review enumerates the challenges involved in protein and peptide delivery via the oral route, i.e., non-invasive routes of protein and peptide administration. This review also covers the chemistry behind SNAC and toxicity as well as mechanisms to enhance the oral delivery of clinically proven molecules like simaglutide and other small molecules under clinical development, as well as other permeation enhancers for efficient delivery of proteins and peptides. |
| doi_str_mv | 10.1007/s11095-022-03459-9 |
| format | Article |
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The delivery of proteins and peptides via an oral route poses numerous challenges to improve the oral bioavailability and patient compliance. To overcome these challenges, as well as to improve the permeation of proteins and peptides via intestinal mucosa, several chemicals have been studied such as surfactants, fatty acids, bile salts, pH modifiers, and chelating agents, amongst these medium chain fatty acid like C10 (sodium caprate) and Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC) and its derivatives that have been well studied from a clinical perspective. This current review enumerates the challenges involved in protein and peptide delivery via the oral route, i.e., non-invasive routes of protein and peptide administration. This review also covers the chemistry behind SNAC and toxicity as well as mechanisms to enhance the oral delivery of clinically proven molecules like simaglutide and other small molecules under clinical development, as well as other permeation enhancers for efficient delivery of proteins and peptides.</description><identifier>ISSN: 0724-8741</identifier><identifier>ISSN: 1573-904X</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-022-03459-9</identifier><identifier>PMID: 36539668</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Administration, Oral ; Bioavailability ; Biochemistry ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Chelating agents ; Fatty acids ; Fatty Acids - metabolism ; Humans ; Intestinal Absorption ; Intestinal Mucosa - metabolism ; Medical Law ; Oral administration ; Patient compliance ; Peptides ; Pharmaceutical Preparations - metabolism ; Pharmacology/Toxicology ; Pharmacy ; Proteins ; Proteins - metabolism ; Review Article ; Surface active agents ; Toxicity</subject><ispartof>Pharmaceutical research, 2023-03, Vol.40 (3), p.633-650</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-1dd8d60202cd6776f83a6624f5e7123c9ce5b181371071a45631c8a4481a4e1e3</citedby><cites>FETCH-LOGICAL-c442t-1dd8d60202cd6776f83a6624f5e7123c9ce5b181371071a45631c8a4481a4e1e3</cites><orcidid>0000-0003-4771-7925</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11095-022-03459-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11095-022-03459-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36539668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kommineni, Nagavendra</creatorcontrib><creatorcontrib>Sainaga Jyothi, Vaskuri G S</creatorcontrib><creatorcontrib>Butreddy, Arun</creatorcontrib><creatorcontrib>Raju, Saka</creatorcontrib><creatorcontrib>Shapira, Tovi</creatorcontrib><creatorcontrib>Khan, Wahid</creatorcontrib><creatorcontrib>Angsantikul, Pavimol</creatorcontrib><creatorcontrib>Domb, Abraham J.</creatorcontrib><title>SNAC for Enhanced Oral Bioavailability: An Updated Review</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><addtitle>Pharm Res</addtitle><description>
The delivery of proteins and peptides via an oral route poses numerous challenges to improve the oral bioavailability and patient compliance. To overcome these challenges, as well as to improve the permeation of proteins and peptides via intestinal mucosa, several chemicals have been studied such as surfactants, fatty acids, bile salts, pH modifiers, and chelating agents, amongst these medium chain fatty acid like C10 (sodium caprate) and Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC) and its derivatives that have been well studied from a clinical perspective. This current review enumerates the challenges involved in protein and peptide delivery via the oral route, i.e., non-invasive routes of protein and peptide administration. This review also covers the chemistry behind SNAC and toxicity as well as mechanisms to enhance the oral delivery of clinically proven molecules like simaglutide and other small molecules under clinical development, as well as other permeation enhancers for efficient delivery of proteins and peptides.</description><subject>Administration, Oral</subject><subject>Bioavailability</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Chelating agents</subject><subject>Fatty acids</subject><subject>Fatty Acids - metabolism</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Medical Law</subject><subject>Oral administration</subject><subject>Patient compliance</subject><subject>Peptides</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Proteins</subject><subject>Proteins - metabolism</subject><subject>Review Article</subject><subject>Surface active agents</subject><subject>Toxicity</subject><issn>0724-8741</issn><issn>1573-904X</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kV9rFDEUxYNU7Lb6BXyQgb70ZWpu_se37bK1hWJBXfAtZDN32pTZmTWZrfTbm3WrS0UkD5fk_s7hhEPIW6BnQKl-nwGolTVlrKZcSFvbF2QCUvPaUvHtgEyoZqI2WsAhOcr5nlJqwIpX5JArya1SZkLsl0_TWdUOqZr3d74P2FQ3yXfVeRz8g4-dX8Yujo8fqmlfLdaNHwvwGR8i_nhNXra-y_jmaR6TxcX86-yyvr75eDWbXtdBCDbW0DSmUZRRFhqltWoN90ox0UrUwHiwAeUSDHANVIMXUnEIxgthygUB-TE53fmu0_B9g3l0q5gDdp3vcdhkx7RUSoNgpqAnf6H3wyb1JV2hjDWGc2r31K3v0MW-Hcbkw9bUTXWxkSA0K9TZP6hyGlzFMPTYxvL-TMB2gpCGnBO2bp3iyqdHB9Rt-3K7vlzpy_3qy22zvHtKvFmusPkj-V1QAfgOyGXV32Laf-k_tj8B-dCa5A</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Kommineni, Nagavendra</creator><creator>Sainaga Jyothi, Vaskuri G S</creator><creator>Butreddy, Arun</creator><creator>Raju, Saka</creator><creator>Shapira, Tovi</creator><creator>Khan, Wahid</creator><creator>Angsantikul, Pavimol</creator><creator>Domb, Abraham J.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4771-7925</orcidid></search><sort><creationdate>20230301</creationdate><title>SNAC for Enhanced Oral Bioavailability: An Updated Review</title><author>Kommineni, Nagavendra ; 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The delivery of proteins and peptides via an oral route poses numerous challenges to improve the oral bioavailability and patient compliance. To overcome these challenges, as well as to improve the permeation of proteins and peptides via intestinal mucosa, several chemicals have been studied such as surfactants, fatty acids, bile salts, pH modifiers, and chelating agents, amongst these medium chain fatty acid like C10 (sodium caprate) and Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC) and its derivatives that have been well studied from a clinical perspective. This current review enumerates the challenges involved in protein and peptide delivery via the oral route, i.e., non-invasive routes of protein and peptide administration. This review also covers the chemistry behind SNAC and toxicity as well as mechanisms to enhance the oral delivery of clinically proven molecules like simaglutide and other small molecules under clinical development, as well as other permeation enhancers for efficient delivery of proteins and peptides.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36539668</pmid><doi>10.1007/s11095-022-03459-9</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0003-4771-7925</orcidid></addata></record> |
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| ispartof | Pharmaceutical research, 2023-03, Vol.40 (3), p.633-650 |
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| subjects | Administration, Oral Bioavailability Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chelating agents Fatty acids Fatty Acids - metabolism Humans Intestinal Absorption Intestinal Mucosa - metabolism Medical Law Oral administration Patient compliance Peptides Pharmaceutical Preparations - metabolism Pharmacology/Toxicology Pharmacy Proteins Proteins - metabolism Review Article Surface active agents Toxicity |
| title | SNAC for Enhanced Oral Bioavailability: An Updated Review |
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