Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review
Purpose In the past few decades, acromegaly and colonic polyps have been associated with an increased risk of colorectal cancer. Previous studies highlighted the importance of serum biomarkers of colonic polyps in patients with acromegaly. Methods We reviewed studies on serum biomarkers of colonic p...
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| Veröffentlicht in: | Pituitary 2023-02, Vol.26 (1), p.1-8 |
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| creator | Ji, Xiaoyu Fu, Jiajia Li, Xiaozhe Yuan, Kun Sun, Xuebo Yao, Qiaoling |
| description | Purpose
In the past few decades, acromegaly and colonic polyps have been associated with an increased risk of colorectal cancer. Previous studies highlighted the importance of serum biomarkers of colonic polyps in patients with acromegaly.
Methods
We reviewed studies on serum biomarkers of colonic polyps in patients with acromegaly, published on PubMed, Embase, Cochrane Library, Medline, and Chinese databases from January 1, 1966, to May 8, 2022. Meta-analysis and systematic review were conducted using Stata MP 14.0.
Results
Eight articles were included in this study. The mean (standard deviation) concentrations of serum biomarkers for acromegaly with and without colorectal polyps were extracted from these studies. Meta-analysis results showed that, compared to patients without colonic polyps, the levels of insulin-like growth factor-1 × upper limit of normal range (IGF-1 × ULN) and fasting insulin were significantly increased; while the levels of growth hormone (GH) were significantly decreased in patients with acromegaly and colonic polyps (IGF-1 × ULN: SMD 0.23; 95% CI 0.03–0.42,
p
|
| doi_str_mv | 10.1007/s11102-022-01287-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2756669843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2756669843</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-10149033bf1609860c52a8d12b0bbd811a77f643a240eed5d141118df62deb833</originalsourceid><addsrcrecordid>eNp9kE1P3DAQhi1UxC4ff6CHysdeQv0V29tbtaIFaSUOgMTNcpLJ1jSJU09StPx6vCztsYfRzGje95XmIeQjZ5ecMfMFOedMFEzk4sKa4uWILHlpZGEUkx_yLK0upOKPC3KK-MRYtkl1QhZSl0oIY5cE7iDNPa1C7H36BQlpbGkduziEmo6x241Iw0BHPwUYJqTPYfpJfZ1iD1vf7b5ST3uYfOGHvGFA6oeG4g4n6LOlpgn-BHg-J8et7xAu3vsZefh-db--Lja3P27W3zZFLZWZCs64WjEpq5ZrtrKa1aXwtuGiYlXVWM69Ma1W0gvFAJqy4SojsE2rRQOVlfKMfD7kjin-ngEn1wesoev8AHFGJ0yptV5ZtZeKgzT_gpigdWMKmcHOceb2eN0Br8t43Rte95JNn97z56qH5p_lL88skAcB5tOwheSe4pwyG_xf7CthqYbu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2756669843</pqid></control><display><type>article</type><title>Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ji, Xiaoyu ; Fu, Jiajia ; Li, Xiaozhe ; Yuan, Kun ; Sun, Xuebo ; Yao, Qiaoling</creator><creatorcontrib>Ji, Xiaoyu ; Fu, Jiajia ; Li, Xiaozhe ; Yuan, Kun ; Sun, Xuebo ; Yao, Qiaoling</creatorcontrib><description>Purpose
In the past few decades, acromegaly and colonic polyps have been associated with an increased risk of colorectal cancer. Previous studies highlighted the importance of serum biomarkers of colonic polyps in patients with acromegaly.
Methods
We reviewed studies on serum biomarkers of colonic polyps in patients with acromegaly, published on PubMed, Embase, Cochrane Library, Medline, and Chinese databases from January 1, 1966, to May 8, 2022. Meta-analysis and systematic review were conducted using Stata MP 14.0.
Results
Eight articles were included in this study. The mean (standard deviation) concentrations of serum biomarkers for acromegaly with and without colorectal polyps were extracted from these studies. Meta-analysis results showed that, compared to patients without colonic polyps, the levels of insulin-like growth factor-1 × upper limit of normal range (IGF-1 × ULN) and fasting insulin were significantly increased; while the levels of growth hormone (GH) were significantly decreased in patients with acromegaly and colonic polyps (IGF-1 × ULN: SMD 0.23; 95% CI 0.03–0.42,
p
< 0.05) (fasting insulin: SMD 0.95; 9 5% CI 0.11–1.8,
p
< 0.05) (GH: SMD − 0.25; 95% CI − 0.41 to − 0.08,
p
< 0.05). IGF-1 and FPG levels did not differ significantly (IGF-1: SMD -0.03; 95% CI − 0.22 to 0.17,
p
> 0.05) (FPG: SMD 0.14; 95% CI − 0.23 to 0.52,
p
> 0.05). The systematic review results suggest no significant differences in hemoglobin A1C, TSH, free thyroxine, FT4, T3, PRL, total cholesterol, HDL, LDL, fibrinogen, clathrate antigen, serum antigen 19-9, and α-fetoprotein levels, but serum Klotho levels.
Conclusion
We present the first meta-analysis and systematic review of serum biomarkers in patients with acromegaly or colonic polyps. The prevalence of colonic lesion polyps, is associated with higher IGF-1 × ULN levels, higher insulin levels in acromegaly. Further research is required to confirm GH and serum soluble Klotho levels as biomarkers of colonic polyps. When IGF-1 × ULN, fasting insulin levels change in patients with acromegaly, the occurrence of colonic polyps should be monitored. Early detection may reduce the possibility of developing malignant colon neoplasms.</description><identifier>ISSN: 1386-341X</identifier><identifier>EISSN: 1573-7403</identifier><identifier>DOI: 10.1007/s11102-022-01287-z</identifier><identifier>PMID: 36542278</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acromegaly - epidemiology ; Biomarkers ; Colonic Polyps - epidemiology ; Endocrinology ; Growth Hormone ; Human Growth Hormone ; Human Physiology ; Humans ; Insulin ; Insulin-Like Growth Factor I - analysis ; Medicine ; Medicine & Public Health</subject><ispartof>Pituitary, 2023-02, Vol.26 (1), p.1-8</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-10149033bf1609860c52a8d12b0bbd811a77f643a240eed5d141118df62deb833</citedby><cites>FETCH-LOGICAL-c347t-10149033bf1609860c52a8d12b0bbd811a77f643a240eed5d141118df62deb833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11102-022-01287-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11102-022-01287-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36542278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ji, Xiaoyu</creatorcontrib><creatorcontrib>Fu, Jiajia</creatorcontrib><creatorcontrib>Li, Xiaozhe</creatorcontrib><creatorcontrib>Yuan, Kun</creatorcontrib><creatorcontrib>Sun, Xuebo</creatorcontrib><creatorcontrib>Yao, Qiaoling</creatorcontrib><title>Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review</title><title>Pituitary</title><addtitle>Pituitary</addtitle><addtitle>Pituitary</addtitle><description>Purpose
In the past few decades, acromegaly and colonic polyps have been associated with an increased risk of colorectal cancer. Previous studies highlighted the importance of serum biomarkers of colonic polyps in patients with acromegaly.
Methods
We reviewed studies on serum biomarkers of colonic polyps in patients with acromegaly, published on PubMed, Embase, Cochrane Library, Medline, and Chinese databases from January 1, 1966, to May 8, 2022. Meta-analysis and systematic review were conducted using Stata MP 14.0.
Results
Eight articles were included in this study. The mean (standard deviation) concentrations of serum biomarkers for acromegaly with and without colorectal polyps were extracted from these studies. Meta-analysis results showed that, compared to patients without colonic polyps, the levels of insulin-like growth factor-1 × upper limit of normal range (IGF-1 × ULN) and fasting insulin were significantly increased; while the levels of growth hormone (GH) were significantly decreased in patients with acromegaly and colonic polyps (IGF-1 × ULN: SMD 0.23; 95% CI 0.03–0.42,
p
< 0.05) (fasting insulin: SMD 0.95; 9 5% CI 0.11–1.8,
p
< 0.05) (GH: SMD − 0.25; 95% CI − 0.41 to − 0.08,
p
< 0.05). IGF-1 and FPG levels did not differ significantly (IGF-1: SMD -0.03; 95% CI − 0.22 to 0.17,
p
> 0.05) (FPG: SMD 0.14; 95% CI − 0.23 to 0.52,
p
> 0.05). The systematic review results suggest no significant differences in hemoglobin A1C, TSH, free thyroxine, FT4, T3, PRL, total cholesterol, HDL, LDL, fibrinogen, clathrate antigen, serum antigen 19-9, and α-fetoprotein levels, but serum Klotho levels.
Conclusion
We present the first meta-analysis and systematic review of serum biomarkers in patients with acromegaly or colonic polyps. The prevalence of colonic lesion polyps, is associated with higher IGF-1 × ULN levels, higher insulin levels in acromegaly. Further research is required to confirm GH and serum soluble Klotho levels as biomarkers of colonic polyps. When IGF-1 × ULN, fasting insulin levels change in patients with acromegaly, the occurrence of colonic polyps should be monitored. Early detection may reduce the possibility of developing malignant colon neoplasms.</description><subject>Acromegaly - epidemiology</subject><subject>Biomarkers</subject><subject>Colonic Polyps - epidemiology</subject><subject>Endocrinology</subject><subject>Growth Hormone</subject><subject>Human Growth Hormone</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><issn>1386-341X</issn><issn>1573-7403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi1UxC4ff6CHysdeQv0V29tbtaIFaSUOgMTNcpLJ1jSJU09StPx6vCztsYfRzGje95XmIeQjZ5ecMfMFOedMFEzk4sKa4uWILHlpZGEUkx_yLK0upOKPC3KK-MRYtkl1QhZSl0oIY5cE7iDNPa1C7H36BQlpbGkduziEmo6x241Iw0BHPwUYJqTPYfpJfZ1iD1vf7b5ST3uYfOGHvGFA6oeG4g4n6LOlpgn-BHg-J8et7xAu3vsZefh-db--Lja3P27W3zZFLZWZCs64WjEpq5ZrtrKa1aXwtuGiYlXVWM69Ma1W0gvFAJqy4SojsE2rRQOVlfKMfD7kjin-ngEn1wesoev8AHFGJ0yptV5ZtZeKgzT_gpigdWMKmcHOceb2eN0Br8t43Rte95JNn97z56qH5p_lL88skAcB5tOwheSe4pwyG_xf7CthqYbu</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Ji, Xiaoyu</creator><creator>Fu, Jiajia</creator><creator>Li, Xiaozhe</creator><creator>Yuan, Kun</creator><creator>Sun, Xuebo</creator><creator>Yao, Qiaoling</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230201</creationdate><title>Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review</title><author>Ji, Xiaoyu ; Fu, Jiajia ; Li, Xiaozhe ; Yuan, Kun ; Sun, Xuebo ; Yao, Qiaoling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-10149033bf1609860c52a8d12b0bbd811a77f643a240eed5d141118df62deb833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acromegaly - epidemiology</topic><topic>Biomarkers</topic><topic>Colonic Polyps - epidemiology</topic><topic>Endocrinology</topic><topic>Growth Hormone</topic><topic>Human Growth Hormone</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji, Xiaoyu</creatorcontrib><creatorcontrib>Fu, Jiajia</creatorcontrib><creatorcontrib>Li, Xiaozhe</creatorcontrib><creatorcontrib>Yuan, Kun</creatorcontrib><creatorcontrib>Sun, Xuebo</creatorcontrib><creatorcontrib>Yao, Qiaoling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pituitary</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji, Xiaoyu</au><au>Fu, Jiajia</au><au>Li, Xiaozhe</au><au>Yuan, Kun</au><au>Sun, Xuebo</au><au>Yao, Qiaoling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review</atitle><jtitle>Pituitary</jtitle><stitle>Pituitary</stitle><addtitle>Pituitary</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>26</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1386-341X</issn><eissn>1573-7403</eissn><abstract>Purpose
In the past few decades, acromegaly and colonic polyps have been associated with an increased risk of colorectal cancer. Previous studies highlighted the importance of serum biomarkers of colonic polyps in patients with acromegaly.
Methods
We reviewed studies on serum biomarkers of colonic polyps in patients with acromegaly, published on PubMed, Embase, Cochrane Library, Medline, and Chinese databases from January 1, 1966, to May 8, 2022. Meta-analysis and systematic review were conducted using Stata MP 14.0.
Results
Eight articles were included in this study. The mean (standard deviation) concentrations of serum biomarkers for acromegaly with and without colorectal polyps were extracted from these studies. Meta-analysis results showed that, compared to patients without colonic polyps, the levels of insulin-like growth factor-1 × upper limit of normal range (IGF-1 × ULN) and fasting insulin were significantly increased; while the levels of growth hormone (GH) were significantly decreased in patients with acromegaly and colonic polyps (IGF-1 × ULN: SMD 0.23; 95% CI 0.03–0.42,
p
< 0.05) (fasting insulin: SMD 0.95; 9 5% CI 0.11–1.8,
p
< 0.05) (GH: SMD − 0.25; 95% CI − 0.41 to − 0.08,
p
< 0.05). IGF-1 and FPG levels did not differ significantly (IGF-1: SMD -0.03; 95% CI − 0.22 to 0.17,
p
> 0.05) (FPG: SMD 0.14; 95% CI − 0.23 to 0.52,
p
> 0.05). The systematic review results suggest no significant differences in hemoglobin A1C, TSH, free thyroxine, FT4, T3, PRL, total cholesterol, HDL, LDL, fibrinogen, clathrate antigen, serum antigen 19-9, and α-fetoprotein levels, but serum Klotho levels.
Conclusion
We present the first meta-analysis and systematic review of serum biomarkers in patients with acromegaly or colonic polyps. The prevalence of colonic lesion polyps, is associated with higher IGF-1 × ULN levels, higher insulin levels in acromegaly. Further research is required to confirm GH and serum soluble Klotho levels as biomarkers of colonic polyps. When IGF-1 × ULN, fasting insulin levels change in patients with acromegaly, the occurrence of colonic polyps should be monitored. Early detection may reduce the possibility of developing malignant colon neoplasms.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36542278</pmid><doi>10.1007/s11102-022-01287-z</doi><tpages>8</tpages></addata></record> |
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| subjects | Acromegaly - epidemiology Biomarkers Colonic Polyps - epidemiology Endocrinology Growth Hormone Human Growth Hormone Human Physiology Humans Insulin Insulin-Like Growth Factor I - analysis Medicine Medicine & Public Health |
| title | Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review |
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