Brd4 proteolysis-targeting chimera nanoparticles sensitized colorectal cancer chemotherapy

Bromodomain-Containing Protein 4 (BRD4) is a member of the BET family of bromodomains, which participates in gene transcription process and is closely related to tumor progression. We observed the up-regulated expression of BRD4 in colorectal cancer (CRC) after doxorubicin (DOX) treatment, which mig...

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Veröffentlicht in:	Journal of controlled release 2023-02, Vol.354, p.155-166
Hauptverfasser:	He, Yihong, Ju, Yan, Hu, Yuzhu, Wang, Bilan, Che, Siyao, Jian, Yue, Zhuo, Weiling, Fu, Xianghui, Cheng, Yongzhong, Zheng, Songping, Huang, Ning, Qian, Zhiyong, Liu, Jiagang, Zhou, Peizhi, Gao, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	BRD4 PROTAC degrader ARV-825 Colorectal cancer Combination therapy Nanoparticles Resistance
Online-Zugang:	Volltext
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