Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity

Microglia continuously survey the brain parenchyma and actively shift status following stimulation. These processes demand a unique bioenergetic programme; however, little is known about the metabolic determinants in microglia. By mining large datasets and generating transgenic tools, here we show t...

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Veröffentlicht in:	Nature metabolism 2022-12, Vol.4 (12), p.1756-1774
Hauptverfasser:	Hu, Yaling, Cao, Kelei, Wang, Fang, Wu, Weiying, Mai, Weihao, Qiu, Liyao, Luo, Yuxiang, Ge, Woo-ping, Sun, Binggui, Shi, Ligen, Zhu, Junming, Zhang, Jianmin, Wu, Zhiying, Xie, Yicheng, Duan, Shumin, Gao, Zhihua
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/31 13/51 14 14/19 14/32 14/34 14/63 14/69 38 38/61 38/77 38/91 631/378/2596/1953 631/378/371 631/443/319 Animals Biomedical and Life Sciences Brain Ischemia - genetics Brain Ischemia - metabolism Hexokinase - genetics Hexokinase - metabolism Life Sciences Male Mice Microglia - metabolism Mitochondria - metabolism Stroke - genetics Stroke - metabolism
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