Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity

CD73 (ecto-5′-nucleotidase) has emerged as an attractive target for cancer immunotherapy of many cancers. CD73 catalyzes the hydrolysis of adenosine monophosphate (AMP) into highly immunosuppressive adenosine that plays a critical role in tumor progression. Herein, we report our efforts in developin...

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Veröffentlicht in:	Journal of medicinal chemistry 2023-01, Vol.66 (1), p.345-370
Hauptverfasser:	Li, Jim, Chen, Lijing, Billedeau, Roland J., Stanton, Timothy F., Chiang, John T. P., Lee, Clarissa C., Li, Weiqun, Steggerda, Susanne, Emberley, Ethan, Gross, Matthew, Bhupathi, Deepthi, Che, Xiaoying, Chen, Jason, Dang, Rosalyn, Huang, Tony, Ma, Yong, MacKinnon, Andrew, Makkouk, Amani, Marguier, Gisele, Neou, Silinda, Sotirovska, Natalija, Spurlock, Sandra, Zhang, Jing, Zhang, Winter, van Zandt, Michael, Yuan, Lin, Savoy, Jennifer, Parlati, Francesco, Sjogren, Eric B.
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase Adenosine Monophosphate Animals CD8-Positive T-Lymphocytes Disease Models, Animal Mice Neoplasms - drug therapy Nucleosides
Online-Zugang:	Volltext
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