Clinical significance of oxidized low-density lipoprotein antibody in antiphospholipid syndrome
To investigate the significance and distribution of oxidized low-density lipoprotein antibodies (ox-LDL-Ab) in patients with antiphospholipid syndrome (APS). In this study, 334 patients who were hospitalized in the Department of Rheumatology and Immunology, Peking University People's Hospital w...
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| Veröffentlicht in: | Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2022-12, Vol.54 (6), p.1117-1122 |
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| container_title | Beijing da xue xue bao. Journal of Peking University. Yi xue ban |
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| creator | Hou, Y K Cai, Q M Liu, X J Yun, Z L Li, C Zhang, X W |
| description | To investigate the significance and distribution of oxidized low-density lipoprotein antibodies (ox-LDL-Ab) in patients with antiphospholipid syndrome (APS).
In this study, 334 patients who were hospitalized in the Department of Rheumatology and Immunology, Peking University People's Hospital were included. There were 162 APS patients, 122 patients with other autoimmune diseases without thrombosis or obstetric disease as disease control and 50 healthy controls. The clinical data and laboratory indicators were retrospectively collected. The ox-LDL-Ab, anticardiolipin (aCL) IgG/IgA/IgM, and anti-β2-glycoprotein Ⅰ (aβ2GPI) IgG/IgA/IgM were detected by enzyme-linked immunosorbent assay (ELISA). The relationship between ox-LDL-Ab and clinical and laboratory parameters were analyzed by SPSS 27.0.
In APS group, 60.5% of patients had thrombosis, 48.1% had pregnancy morbidity, 34.0% had thrombocytopenia. The positive rates of aCL, aβ2GPI and lupus anticoagulant (LAC) were 17.9%, 34.6%, and 46.9%, respectively. The ox- |
| doi_str_mv | 10.19723/j.issn.1671-167X.2022.06.010 |
| format | Article |
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In this study, 334 patients who were hospitalized in the Department of Rheumatology and Immunology, Peking University People's Hospital were included. There were 162 APS patients, 122 patients with other autoimmune diseases without thrombosis or obstetric disease as disease control and 50 healthy controls. The clinical data and laboratory indicators were retrospectively collected. The ox-LDL-Ab, anticardiolipin (aCL) IgG/IgA/IgM, and anti-β2-glycoprotein Ⅰ (aβ2GPI) IgG/IgA/IgM were detected by enzyme-linked immunosorbent assay (ELISA). The relationship between ox-LDL-Ab and clinical and laboratory parameters were analyzed by SPSS 27.0.
In APS group, 60.5% of patients had thrombosis, 48.1% had pregnancy morbidity, 34.0% had thrombocytopenia. The positive rates of aCL, aβ2GPI and lupus anticoagulant (LAC) were 17.9%, 34.6%, and 46.9%, respectively. The ox-</description><identifier>ISSN: 1671-167X</identifier><identifier>DOI: 10.19723/j.issn.1671-167X.2022.06.010</identifier><identifier>PMID: 36533342</identifier><language>chi</language><publisher>China</publisher><subject>Antibodies, Anticardiolipin ; Antiphospholipid Syndrome ; Autoantibodies ; beta 2-Glycoprotein I ; Clinical Relevance ; Coronary Artery Disease ; Female ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Lipoproteins, LDL ; Lupus Coagulation Inhibitor ; Pregnancy ; Retrospective Studies ; Thrombosis</subject><ispartof>Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2022-12, Vol.54 (6), p.1117-1122</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36533342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Y K</creatorcontrib><creatorcontrib>Cai, Q M</creatorcontrib><creatorcontrib>Liu, X J</creatorcontrib><creatorcontrib>Yun, Z L</creatorcontrib><creatorcontrib>Li, C</creatorcontrib><creatorcontrib>Zhang, X W</creatorcontrib><title>Clinical significance of oxidized low-density lipoprotein antibody in antiphospholipid syndrome</title><title>Beijing da xue xue bao. Journal of Peking University. Yi xue ban</title><addtitle>Beijing Da Xue Xue Bao Yi Xue Ban</addtitle><description>To investigate the significance and distribution of oxidized low-density lipoprotein antibodies (ox-LDL-Ab) in patients with antiphospholipid syndrome (APS).
In this study, 334 patients who were hospitalized in the Department of Rheumatology and Immunology, Peking University People's Hospital were included. There were 162 APS patients, 122 patients with other autoimmune diseases without thrombosis or obstetric disease as disease control and 50 healthy controls. The clinical data and laboratory indicators were retrospectively collected. The ox-LDL-Ab, anticardiolipin (aCL) IgG/IgA/IgM, and anti-β2-glycoprotein Ⅰ (aβ2GPI) IgG/IgA/IgM were detected by enzyme-linked immunosorbent assay (ELISA). The relationship between ox-LDL-Ab and clinical and laboratory parameters were analyzed by SPSS 27.0.
In APS group, 60.5% of patients had thrombosis, 48.1% had pregnancy morbidity, 34.0% had thrombocytopenia. The positive rates of aCL, aβ2GPI and lupus anticoagulant (LAC) were 17.9%, 34.6%, and 46.9%, respectively. The ox-</description><subject>Antibodies, Anticardiolipin</subject><subject>Antiphospholipid Syndrome</subject><subject>Autoantibodies</subject><subject>beta 2-Glycoprotein I</subject><subject>Clinical Relevance</subject><subject>Coronary Artery Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Lipoproteins, LDL</subject><subject>Lupus Coagulation Inhibitor</subject><subject>Pregnancy</subject><subject>Retrospective Studies</subject><subject>Thrombosis</subject><issn>1671-167X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhbNQnGGcvyDZCG5a85gk7VIGdYQBNwruSl7VK2lSmw5af70FRxfnnsPl43I5CF1SUtJaMX79XkLOsaRS0WIeLyUjjJVEloSSE7T83y_QOmcwhFBKeE35GVpwKTjnG7ZEzTZABKsDzvAaoZ1jtB6nFqcvcPDtHQ7ps3A-ZhgnHKBP_ZBGDxHrOIJJbsLH3L-lPGtGwOE8RTekzp-j01aH7NdHX6Hnu9un7a7YP94_bG_2RU-ZHAvZKmGYYpJb77zVta2k1sR4TmtrtCFmU7WcVNw467SpKKvURhBnasqMUJKv0NXv3fm7j4PPY9NBtj4EHX065IYpISpCFRMzenFED6bzrukH6PQwNX-l8B_Fz2kj</recordid><startdate>20221218</startdate><enddate>20221218</enddate><creator>Hou, Y K</creator><creator>Cai, Q M</creator><creator>Liu, X J</creator><creator>Yun, Z L</creator><creator>Li, C</creator><creator>Zhang, X W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20221218</creationdate><title>Clinical significance of oxidized low-density lipoprotein antibody in antiphospholipid syndrome</title><author>Hou, Y K ; Cai, Q M ; Liu, X J ; Yun, Z L ; Li, C ; Zhang, X W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-6f75b27263cedeca9c86aa0be319cbab0b48f3083bdcdab81287450db912b5763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2022</creationdate><topic>Antibodies, Anticardiolipin</topic><topic>Antiphospholipid Syndrome</topic><topic>Autoantibodies</topic><topic>beta 2-Glycoprotein I</topic><topic>Clinical Relevance</topic><topic>Coronary Artery Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Lipoproteins, LDL</topic><topic>Lupus Coagulation Inhibitor</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Y K</creatorcontrib><creatorcontrib>Cai, Q M</creatorcontrib><creatorcontrib>Liu, X J</creatorcontrib><creatorcontrib>Yun, Z L</creatorcontrib><creatorcontrib>Li, C</creatorcontrib><creatorcontrib>Zhang, X W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Beijing da xue xue bao. Journal of Peking University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Y K</au><au>Cai, Q M</au><au>Liu, X J</au><au>Yun, Z L</au><au>Li, C</au><au>Zhang, X W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of oxidized low-density lipoprotein antibody in antiphospholipid syndrome</atitle><jtitle>Beijing da xue xue bao. Journal of Peking University. Yi xue ban</jtitle><addtitle>Beijing Da Xue Xue Bao Yi Xue Ban</addtitle><date>2022-12-18</date><risdate>2022</risdate><volume>54</volume><issue>6</issue><spage>1117</spage><epage>1122</epage><pages>1117-1122</pages><issn>1671-167X</issn><abstract>To investigate the significance and distribution of oxidized low-density lipoprotein antibodies (ox-LDL-Ab) in patients with antiphospholipid syndrome (APS).
In this study, 334 patients who were hospitalized in the Department of Rheumatology and Immunology, Peking University People's Hospital were included. There were 162 APS patients, 122 patients with other autoimmune diseases without thrombosis or obstetric disease as disease control and 50 healthy controls. The clinical data and laboratory indicators were retrospectively collected. The ox-LDL-Ab, anticardiolipin (aCL) IgG/IgA/IgM, and anti-β2-glycoprotein Ⅰ (aβ2GPI) IgG/IgA/IgM were detected by enzyme-linked immunosorbent assay (ELISA). The relationship between ox-LDL-Ab and clinical and laboratory parameters were analyzed by SPSS 27.0.
In APS group, 60.5% of patients had thrombosis, 48.1% had pregnancy morbidity, 34.0% had thrombocytopenia. The positive rates of aCL, aβ2GPI and lupus anticoagulant (LAC) were 17.9%, 34.6%, and 46.9%, respectively. The ox-</abstract><cop>China</cop><pmid>36533342</pmid><doi>10.19723/j.issn.1671-167X.2022.06.010</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antibodies, Anticardiolipin Antiphospholipid Syndrome Autoantibodies beta 2-Glycoprotein I Clinical Relevance Coronary Artery Disease Female Humans Immunoglobulin A Immunoglobulin G Immunoglobulin M Lipoproteins, LDL Lupus Coagulation Inhibitor Pregnancy Retrospective Studies Thrombosis |
| title | Clinical significance of oxidized low-density lipoprotein antibody in antiphospholipid syndrome |
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