Association of platelet-to-neutrophil ratios with 1-year outcome and mortality in patients with acute ischemic stroke

•718 patients were included to assess the predictive value of PNR on 1-year outcome.•PNR may serve as a marker for early predicting the long-term prognosis of AIS.•PNR, NIHSS, RBCs and age could construct a risk model for 1-year mortality of AIS. Platelet-neutrophil crosstalk is being increasingly recognized as a driver of inflammation and thrombosis in patients with ischemic stroke. The aim of this study was to investigate the potential of PNR value in predicting the long-term prognosis and evaluate whether or not an available and routine blood cell biomarker could help predict the long-term neurological function and mortality in AIS patients. A total of 718 patients with suspected acute ischemic stroke were involved and followed up for 1 year by standard telephone interview or reexamination. Kaplan-Meier curve, Univariate and Multivariate Cox Regression were analyzed using Statistical Packages for Social Sciences. ROC curve for PNR to evaluate 1-year outcomes was analyzed and the area under the curve (AUC) was 0.659 (P