A2AR limits IL-15-induced generation of CD39+ NK cells with high cytotoxicity

•Human circulating CD39+NK cells displayed higher capacity of degranulation.•The characteristic of CD39+ NK cells was stable in the setting of infection and cancer.•IL-15 promoted the generation of CD39+ NK cells.•A2AR suppressed the generation of CD39+ NK cells by inhibiting IL-15 signaling. CD39-m...

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Veröffentlicht in:	International immunopharmacology 2023-01, Vol.114, p.109567-109567, Article 109567
Hauptverfasser:	Kang, Guijie, Zhao, Xueqin, Sun, Jiafeng, Cheng, Chen, Wang, Cen, Tao, Longxiang, Zong, Lu, Yin, Wenwei, Cong, Jingjing, Li, Jing, Wang, Xuefu
Format:	Artikel
Sprache:	eng
Schlagworte:	A2A adenosine receptor CD39 Cytotoxicity Cytotoxicity, Immunologic Humans IL-15 Interleukin-15 Killer Cells, Natural NK cells Receptor, Adenosine A2A - metabolism
Online-Zugang:	Volltext
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