Recruitment of TRIM33 to cell‐context specific PML nuclear bodies regulates nodal signaling in mESCs

TRIM33 is a chromatin reader required for mammalian mesendoderm differentiation after activation of Nodal signaling, while its role in mESCs is still elusive. Here, we report that TRIM33 co‐localizes with promyelocytic leukemia nuclear bodies (PML‐NBs) specifically in mESCs, to mediate Nodal signali...

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Veröffentlicht in:	The EMBO journal 2023-02, Vol.42 (3), p.e112058-n/a
Hauptverfasser:	Sun, Hongyao, Chen, Yutong, Yan, Kun, Shao, Yanqiu, Zhang, Qiangfeng C, Lin, Yi, Xi, Qiaoran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell differentiation Cell fate Cell Nucleus - metabolism Chromatin Context EMBO09 EMBO11 EMBO32 Gene clusters Gene expression Humans Lefty1/2 Leukemia Life Sciences LLPS Mammals Mesendoderm Mouse Embryonic Stem Cells - metabolism Nodal signaling Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxidative stress PML NBs PML protein Promyelocytic Leukemia Nuclear Bodies Promyelocytic Leukemia Protein - genetics Promyelocytic Leukemia Protein - metabolism Promyeloid leukemia Protein composition Proteins Recruitment Signal Transduction Signaling Transcription Transcription Factors - genetics TRIM33
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