Quercetin decreases cardiac hypertrophic mediators and maladaptive coronary arterial remodeling in renovascular hypertensive rats without improving cardiac function

Oxidative stress and MMP activity are found in the hearts and arteries in hypertension and contribute to the resulting hypertrophy and dysfunction. Quercetin is a flavonoid that reduces MMP-2 activity and ameliorates hypertrophic vascular remodeling of hypertension. The hypothesis is that treatment...

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Veröffentlicht in:Naunyn-Schmiedeberg's archives of pharmacology 2023-05, Vol.396 (5), p.939-949
Hauptverfasser: da Rocha, Eduardo Vieira, Falchetti, Francisco, Pernomian, Laena, de Mello, Marcela M. Blascke, Parente, Juliana M., Nogueira, Renato C., Gomes, Beatriz Q., Bertozi, Giuliana, Sanches-Lopes, Jessica M., Tanus-Santos, José Eduardo, Castro, Michele M.
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Sprache:eng
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