Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms

The contribution of nutrient availability to control epidermal cell proliferation, inflammation, and hyperproliferative diseases remains unknown. Here, we studied extracellular serine and serine/glycine metabolism using human keratinocytes, human skin biopsies, and a mouse model of psoriasis-like di...

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Veröffentlicht in:	Science advances 2022-12, Vol.8 (50), p.eabm7902-eabm7902
Hauptverfasser:	Cappello, Angela, Mancini, Mara, Madonna, Stefania, Rinaldo, Serena, Paone, Alessio, Scarponi, Claudia, Belardo, Antonio, Zolla, Lello, Zuccotti, Alessandro, Panatta, Emanuele, Pallotta, Sabatino, Annicchiarico-Petruzzelli, Margherita, Albanesi, Cristina, Cutruzzolà, Francesca, Wang, Lu, Jia, Wei, Melino, Gerry, Candi, Eleonora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Glycine - metabolism Glycine - pharmacology Glycine Hydroxymethyltransferase - genetics Glycine Hydroxymethyltransferase - metabolism Humans Inflammation - pathology Mice Psoriasis - pathology Serine - metabolism Skin Diseases
Online-Zugang:	Volltext
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