Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group

Tumor cells often exhibit metabolic reprogramming to maintain their rapid growth and proliferation. Glutaminase 1 (GLS1) has been viewed as a promising target in the glutamine metabolism pathway for the treatment of malignant tumors. Using structure-based drug design approaches, a novel series of GL...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-01, Vol.246, p.115014-115014, Article 115014
Hauptverfasser:	Chang, Xiujin, Wang, Min, Zhang, Di, Zhang, Yuqing, Wang, Jubo, Li, Zhiyu, Bian, Jinlei, Xu, Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric inhibitors Cell Proliferation Glutaminase Glutaminase 1 Glutamine - metabolism Heterografts Humans
Online-Zugang:	Volltext
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