Contribution of key elements of nutritional metabolism to the development of cystic ovarian disease in dairy cattle

The alteration of signaling molecules involved in the general metabolism of animals can negatively influence reproduction. In dairy cattle, the development of follicular cysts and the subsequent appearance of ovarian cystic disease (COD) often lead to decreased reproductive efficiency in the herd. The objective of this review is to summarize the contribution of relevant metabolic and nutritional sensors to the development of COD in dairy cows. In particular, we focus on the study of alterations of the insulin signaling pathway, adiponectin, and other sensors and metabolites relevant to ovarian functionality, which may be related to the development of follicular persistence and follicular formation of cysts in dairy cattle. The results of these studies support the hypothesis that systemic factors could alter the local scenario in the follicle, generating an adverse microenvironment for the resumption of ovarian activity and possibly leading to the persistence of follicles and to the development and recurrence of COD. •Signaling molecules of metabolic processes in ovarian follicular structures can alter reproduction.•Metabolic and nutritional sensors contribute to cystic ovarian disease development in dairy cows.•Ovarian insulin and adiponectin response are determinant in the ovarian functionality.•Systemic factors regulate the biochemical environment in the follicle and influence the resumption of ovarian activity.