Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia

Despite exosome promise as endogenous drug delivery vehicles, the current understanding of exosome may be insufficient to develop their various applications. Here we synthesized five sialic acid analogues with different length N-acyl side chains and screened out the optimal metabolic precursor for e...

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Veröffentlicht in:	Journal of controlled release 2023-01, Vol.353, p.675-684
Hauptverfasser:	Zheng, Xue, Sun, Ke, Liu, Yonghui, Yin, Xiaona, Zhu, Haomiao, Yu, Fan, Zhao, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Click chemistry Exosomes Exosomes - metabolism Macrophages Mice Microglia Multiple sclerosis Multiple Sclerosis - drug therapy Resveratrol Resveratrol - metabolism Resveratrol - therapeutic use Sialic acid
Online-Zugang:	Volltext
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