RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG

NMDA receptors play pivotal roles in the neurobiology of chronic stress-induced mood disorders. But the mechanism for chronic stress to disturb the expression of NMDA receptor subunits is still unclear. Recent researches indicated the involvement RAGE signaling pathway in regulation of glutamate sys...

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Veröffentlicht in:	Experimental neurology 2023-03, Vol.361, p.114299-114299, Article 114299
Hauptverfasser:	Zhang, Longjie, Luo, Lan, Xue, Lifen, Ran, Dongzhi, Yang, Fang, Tang, Qiang, Jiang, Wengao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic unpredicted stress (CUS) Dentate gyrus (DG) Depression hippocampus Hippocampus - metabolism Major depressive disorder (MDD) NMDA receptor subtype 2A (NR2A) NMDA receptor subtype 2B (NR2B) Rats Receptor for advanced glycation end-products (RAGE) Receptors, N-Methyl-D-Aspartate - metabolism RNA, Small Interfering - pharmacology Signal Transduction
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