Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway

Glucocorticoids are widely used in clinical practice; however, they can cause side effects, such as osteoporosis. Acteoside (ACT) from Cistanche has been used to combat a variety of diseases. The study was conducted to evaluate the efficacy of ACT in glucocorticoid-induced osteoporosis (GIOP) and it...

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Veröffentlicht in:	Journal of investigative surgery 2023-12, Vol.36 (1), p.2154578-2154578
Hauptverfasser:	Li, Shumei, Cui, Yajie, Li, Min, Zhang, Wenting, Sun, Xiaoxue, Xin, Zhaoxu, Li, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acteoside Animals Cistanche Cistanche - metabolism Core Binding Factor Alpha 1 Subunit - metabolism Core Binding Factor Alpha 1 Subunit - pharmacology Dexamethasone - adverse effects Glucocorticoids - adverse effects glucocorticoids-induced osteoporosis Osteoblasts Osteoporosis - chemically induced Osteoporosis - drug therapy Osteoporosis - prevention & control Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats RNA, Messenger - metabolism TOR Serine-Threonine Kinases
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