Synthetic Lignin-Derived Therapeutic Nano Reagent as Intestinal pH-Sensitive Drug Carriers Capable of Bypassing the Gastric Acid Environment for Colitis Treatment

Oral drug delivery is a common route for management of inflammatory bowel disease (IBD) but suffers from low bioavailability and systemic side effects during passage through the alimentary canal. Here, we present a therapeutic nano reagent of a ferulic acid-derived lignin nanoparticle (FALNP). We sh...

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Veröffentlicht in:	ACS nano 2023-01, Vol.17 (1), p.811-824
Hauptverfasser:	Zhao, Chengke, Yang, Jiali, Chen, Mingfeng, Chen, Wenjun, Yang, Xinyuan, Ye, Heng, Wang, Liying, Wang, Yong, Shi, Jinjin, Yue, Fengxia, Ma, Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colitis - chemically induced Colitis - drug therapy Drug Carriers - therapeutic use Gastric Acid Hydrogen-Ion Concentration Indicators and Reagents Inflammatory Bowel Diseases - drug therapy Intestines - pathology Lignin - therapeutic use Mice
Online-Zugang:	Volltext
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